The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were f...The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.展开更多
Study of molecular recognition has been playing an important role in biomimeticchemistry. β-cyclodextrin (β-CD), the cyclic heptamer of glucopyranose, can form inclusioncomplexes with various types of organic compou...Study of molecular recognition has been playing an important role in biomimeticchemistry. β-cyclodextrin (β-CD), the cyclic heptamer of glucopyranose, can form inclusioncomplexes with various types of organic compounds (substrates) through its展开更多
β-Cyclodextrin （β-CD） and its derivatives functionalized magnetic nanoparticles （MNPs） with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydr...β-Cyclodextrin （β-CD） and its derivatives functionalized magnetic nanoparticles （MNPs） with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxy- propyl/sulfobutyl ether-β-CD-MNPs （CM/HP/SBE-β-CD-MNPs） nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as-prepared nanocarriers for the hydrophobic anti-cancer drug curcumin was also investigated. The results revealed that the SBE-fl-CD-MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE-β-CD-MNPs entered into the cell, and curcumin could be suc-cessfully delivered into the cell by SBE-β-CD-MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE-β-CD-MNPs were non-toxic, while curcumin loaded SBE-β-CD-MNPs showed high potential to kill the HepG2 cells. The as-prepared magnetic composites were expected to expand their potential applications in bio- medical field.展开更多
文摘The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.
文摘Study of molecular recognition has been playing an important role in biomimeticchemistry. β-cyclodextrin (β-CD), the cyclic heptamer of glucopyranose, can form inclusioncomplexes with various types of organic compounds (substrates) through its
文摘β-Cyclodextrin （β-CD） and its derivatives functionalized magnetic nanoparticles （MNPs） with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxy- propyl/sulfobutyl ether-β-CD-MNPs （CM/HP/SBE-β-CD-MNPs） nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as-prepared nanocarriers for the hydrophobic anti-cancer drug curcumin was also investigated. The results revealed that the SBE-fl-CD-MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE-β-CD-MNPs entered into the cell, and curcumin could be suc-cessfully delivered into the cell by SBE-β-CD-MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE-β-CD-MNPs were non-toxic, while curcumin loaded SBE-β-CD-MNPs showed high potential to kill the HepG2 cells. The as-prepared magnetic composites were expected to expand their potential applications in bio- medical field.
