目的评价应用复方利血平氨苯蝶啶片治疗原发性高血压病的疗效、性价比及安全性。方法计算机检索Cochrane Library、Pubmed、Bio Med Central、中国学术期刊全文数据库、维普数据库、万方数据库,收集复方利血平氨苯蝶啶片治疗原发性高血...目的评价应用复方利血平氨苯蝶啶片治疗原发性高血压病的疗效、性价比及安全性。方法计算机检索Cochrane Library、Pubmed、Bio Med Central、中国学术期刊全文数据库、维普数据库、万方数据库,收集复方利血平氨苯蝶啶片治疗原发性高血压病的随机对照试验,按纳入和排除标准由2名评价者独立选择文献,提取资料,交叉核对并进行方法学质量评估,使用Revman5.0软件进行META分析。结果共纳入22项研究,2536例患者。复方利血平氨苯蝶啶片组与钙离子拮抗剂组总有效率之比及其95%可信区间为1.10(0.86~1.41),两组差异无统计学意义(P=0.45);复方利血平氨苯蝶啶片组在控制心率总有效率之比及其95%可信区间为1.25(0.42~2.08),差异有统计学意义(P=0.003);安全性结果:复方利血平氨苯蝶啶片组与钙离子拮抗剂不良事件发生率之差及其95%可信区间为1.13(0.82~1.56),两组差异无统计学意义(P=0.46)。结论根据目前研究证据,复方利血平氨苯蝶啶片与钙离子拮抗剂相比疗效相近、不良事件的发生情况差异不明显,有较为可靠的疗效和安全性。展开更多
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of methods usually used for the determination of diuretics (gas or liquid chromatography, capillary electrophoresis), they do not always provide necessary sensitivity. Moreover, sample preparation increases time of analysis. A rapid and sensitive luminescent method for determination of 5 diuretics (amiloride, bendroflumethiazide, bumetanide, furosemide, triamterene) in aqueous solutions and amiloride and triamterene in human urine is described. Intrinsic luminescent properties of protolytic forms of diuretics were studied in order to provide highly sensitive analysis. Investigation of interfering influence of diuretics was carried out to provide selective determination of triamterene, bumetanide and furosemide in aqueous mixtures of diuretics. Influence of urine at luminescent properties of diuretics was studied. The possibility of determination of triamterene and amiloride in human urine as individual substances and in mixture was proved. Simple and rapid technique for their determination in human urine was elaborated. The techniques elaborated for determination of triamterene in presence of other diuretics and furosemide in presence of commensurate amount of bumetanide allow enhancing specifity of analysis. Sufficient selectivity and sensitivity were reached in determination of amiloride and triamterene in human urine. The reduction of time of analysis due to avoiding sample preparation merits the techniques proposed.展开更多
文摘目的评价应用复方利血平氨苯蝶啶片治疗原发性高血压病的疗效、性价比及安全性。方法计算机检索Cochrane Library、Pubmed、Bio Med Central、中国学术期刊全文数据库、维普数据库、万方数据库,收集复方利血平氨苯蝶啶片治疗原发性高血压病的随机对照试验,按纳入和排除标准由2名评价者独立选择文献,提取资料,交叉核对并进行方法学质量评估,使用Revman5.0软件进行META分析。结果共纳入22项研究,2536例患者。复方利血平氨苯蝶啶片组与钙离子拮抗剂组总有效率之比及其95%可信区间为1.10(0.86~1.41),两组差异无统计学意义(P=0.45);复方利血平氨苯蝶啶片组在控制心率总有效率之比及其95%可信区间为1.25(0.42~2.08),差异有统计学意义(P=0.003);安全性结果:复方利血平氨苯蝶啶片组与钙离子拮抗剂不良事件发生率之差及其95%可信区间为1.13(0.82~1.56),两组差异无统计学意义(P=0.46)。结论根据目前研究证据,复方利血平氨苯蝶啶片与钙离子拮抗剂相比疗效相近、不良事件的发生情况差异不明显,有较为可靠的疗效和安全性。
文摘Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of methods usually used for the determination of diuretics (gas or liquid chromatography, capillary electrophoresis), they do not always provide necessary sensitivity. Moreover, sample preparation increases time of analysis. A rapid and sensitive luminescent method for determination of 5 diuretics (amiloride, bendroflumethiazide, bumetanide, furosemide, triamterene) in aqueous solutions and amiloride and triamterene in human urine is described. Intrinsic luminescent properties of protolytic forms of diuretics were studied in order to provide highly sensitive analysis. Investigation of interfering influence of diuretics was carried out to provide selective determination of triamterene, bumetanide and furosemide in aqueous mixtures of diuretics. Influence of urine at luminescent properties of diuretics was studied. The possibility of determination of triamterene and amiloride in human urine as individual substances and in mixture was proved. Simple and rapid technique for their determination in human urine was elaborated. The techniques elaborated for determination of triamterene in presence of other diuretics and furosemide in presence of commensurate amount of bumetanide allow enhancing specifity of analysis. Sufficient selectivity and sensitivity were reached in determination of amiloride and triamterene in human urine. The reduction of time of analysis due to avoiding sample preparation merits the techniques proposed.
