Southeastern Tibet,which has complex topography and strong tectonic activity,is an important area for studying the subsurface deformation of the Tibetan Plateau.Through the two-station method on 10-year teleseismic Ra...Southeastern Tibet,which has complex topography and strong tectonic activity,is an important area for studying the subsurface deformation of the Tibetan Plateau.Through the two-station method on 10-year teleseismic Rayleigh wave data from 132 permanent stations in the southeastern Tibetan Plateau,which incorporates ambient noise data,we obtain the interstation phase velocity dispersion data in the period range of 5–150s.Then,we invert for the shear wave velocity of the crust and upper mantle through the direct 3-D inversion method.We find two low-velocity belts in the mid-lower crust.One belt is mainly in the SongPan-GangZi block and northwestern part of the Chuan-Dian diamond block,whereas the other belt is mainly in the Xiaojiang fault zone and its eastern part,the Yunnan-Guizhou Plateau.The low-velocity belt in the Xiaojiang fault zone is likely caused by plastic deformation or partial melting of felsic rocks due to crustal thickening.Moreover,the significant positive radial anisotropy(VSH>VSV)around the Xiaojiang fault zone further enhances the amplitude of low velocity anomaly in our VSVmodel.This crustal low-velocity zone also extends southward across the Red River fault and farther to northern Vietnam,which may be closely related to heat sources in the upper mantle.The two low-velocity belts are separated by a high-velocity zone near the Anninghe-Zemuhe fault system,which is exactly in the inner and intermediate zones of the Emeishan large igneous province(ELIP).We find an obvious high-velocity body situated in the crust of the inner zone of the ELIP,which may represent maficultramafic material that remained in the crust when the ELIP formed.In the upper mantle,there is a large-scale low-velocity anomaly in the Indochina and South China blocks south of the Red River fault.The low-velocity anomaly gradually extends northward along the Xiaojiang fault zone into the Yangtze Craton as depth increases.Through our velocity model,we think that southeastern Tibet is undergoing three different tectonic modes at t展开更多
Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar t...Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic waves.The in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue surface.In the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal system.OCT imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal system.Esophagus and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively investigated.OCT imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the submucosa.The technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic lesions.OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis between neoplastic and non-neoplastic lesions.展开更多
Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex pathogenesis.Aggregations formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine ...Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex pathogenesis.Aggregations formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine systems.The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation.Positron emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular levels.Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management.In this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.展开更多
The task to estimate all the parameters of an unknown quantum state, also called quantum state tomography, is essential for characterizing and controlling quantum systems. In this paper, we utilize observable time tra...The task to estimate all the parameters of an unknown quantum state, also called quantum state tomography, is essential for characterizing and controlling quantum systems. In this paper, we utilize observable time traces to identify the initial quantum state of a closed quantum system, based on the state space approach in the control theory. In the informationally complete scenario, we show that with a linear regression estimation (LRE), the mean squared error (MSE) scales as , where N is the resource number. In the informationally incomplete scenario, we introduce regularization LRE to perform the state tomography task. We employ PBH test to demonstrate that closed quantum systems with only one observable are informationally incomplete and propose using observables, where d is the dimension of the quantum state, for informational completeness. Numerical examples demonstrate the effectiveness of our method.展开更多
Dopamine （DA） is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography （PET） is the first technology used for in vivo measurement o...Dopamine （DA） is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography （PET） is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.展开更多
基金supported by Key Research and Development Project of the Ministry of Science and Technology(Grant No.2018YFC1503400)China Earthquake Science Experiment Project,China Earthquake Administration(Grant No.2018CSES0101)。
文摘Southeastern Tibet,which has complex topography and strong tectonic activity,is an important area for studying the subsurface deformation of the Tibetan Plateau.Through the two-station method on 10-year teleseismic Rayleigh wave data from 132 permanent stations in the southeastern Tibetan Plateau,which incorporates ambient noise data,we obtain the interstation phase velocity dispersion data in the period range of 5–150s.Then,we invert for the shear wave velocity of the crust and upper mantle through the direct 3-D inversion method.We find two low-velocity belts in the mid-lower crust.One belt is mainly in the SongPan-GangZi block and northwestern part of the Chuan-Dian diamond block,whereas the other belt is mainly in the Xiaojiang fault zone and its eastern part,the Yunnan-Guizhou Plateau.The low-velocity belt in the Xiaojiang fault zone is likely caused by plastic deformation or partial melting of felsic rocks due to crustal thickening.Moreover,the significant positive radial anisotropy(VSH>VSV)around the Xiaojiang fault zone further enhances the amplitude of low velocity anomaly in our VSVmodel.This crustal low-velocity zone also extends southward across the Red River fault and farther to northern Vietnam,which may be closely related to heat sources in the upper mantle.The two low-velocity belts are separated by a high-velocity zone near the Anninghe-Zemuhe fault system,which is exactly in the inner and intermediate zones of the Emeishan large igneous province(ELIP).We find an obvious high-velocity body situated in the crust of the inner zone of the ELIP,which may represent maficultramafic material that remained in the crust when the ELIP formed.In the upper mantle,there is a large-scale low-velocity anomaly in the Indochina and South China blocks south of the Red River fault.The low-velocity anomaly gradually extends northward along the Xiaojiang fault zone into the Yangtze Craton as depth increases.Through our velocity model,we think that southeastern Tibet is undergoing three different tectonic modes at t
文摘Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic waves.The in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue surface.In the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal system.OCT imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal system.Esophagus and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively investigated.OCT imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the submucosa.The technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic lesions.OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis between neoplastic and non-neoplastic lesions.
基金supported by the National Key Research and Development Program of China(2022YFC2009900,2021YFE0108300,2022YFE0118000,and 2021YFA1101700)the National Natural Science Foundation of China(82030049)Fundamental Research Funds for the Central Universities of China.
文摘Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex pathogenesis.Aggregations formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine systems.The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation.Positron emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular levels.Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management.In this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.
基金supported by the National Natural Science Foundation of China(Nos.62173229,12288201)the Australian Research Council Future Fellowship Funding Scheme under Project FT220100656 and the Discovery Project Funding Scheme under Project DP210101938.
文摘The task to estimate all the parameters of an unknown quantum state, also called quantum state tomography, is essential for characterizing and controlling quantum systems. In this paper, we utilize observable time traces to identify the initial quantum state of a closed quantum system, based on the state space approach in the control theory. In the informationally complete scenario, we show that with a linear regression estimation (LRE), the mean squared error (MSE) scales as , where N is the resource number. In the informationally incomplete scenario, we introduce regularization LRE to perform the state tomography task. We employ PBH test to demonstrate that closed quantum systems with only one observable are informationally incomplete and propose using observables, where d is the dimension of the quantum state, for informational completeness. Numerical examples demonstrate the effectiveness of our method.
基金partly sponsored by the National Basic Research Development Program of China(2013CB329506)the National Natural Science Foundation of China(81301243 and 81271601)+3 种基金the Research Fund for the Doctoral Program of Higher Education of China(20120101120031 and 20130101110015)grants from the Health Bureau of Zhejiang Province(2014KYA095,and WKJ20132-016)the Scientific Research Foundation for Doctors of Second Affiliated Hospital of Zhejiang University School of Medicine (Y560252013)the Natural Science Foundation of Zhejiang Province,China(LR13H180001)
文摘Dopamine （DA） is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography （PET） is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.
