陕西关中盆地的泾阳南塬和西安东郊席王晚更新世黄土剖面底部的S_1古土壤是由4层古土壤及与其相间的3层黄土构成,L_1黄土是由3层黄土及夹于其间的两层古土壤构成。这是目前发现的黄土高原晚更新世黄土-古土壤序列保存较好的剖面。两剖...陕西关中盆地的泾阳南塬和西安东郊席王晚更新世黄土剖面底部的S_1古土壤是由4层古土壤及与其相间的3层黄土构成,L_1黄土是由3层黄土及夹于其间的两层古土壤构成。这是目前发现的黄土高原晚更新世黄土-古土壤序列保存较好的剖面。两剖面的地层结构、磁化率曲线和地球化学组分反映出的12个温湿、冷干气候变化阶段可以归纳为6个气候变化旋回。这是目前建立的我国黄土高原晚更新世(130—10ka B P)较短时间尺度的气候变化模式,它与经典的深海氧同位素记录曲线是不相一致的。展开更多
AIM: To investigate the associations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma(HCC). METHODS: We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospita...AIM: To investigate the associations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma(HCC). METHODS: We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospital of Guangxi Medical University and 1200 non-tumor patients from the First Affiliated Hospital of Guangxi Medical University. General demographic characteristics, behavioral information, and hematological indices were collected by unified questionnaires. Genomic DNA was isolatedfrom peripheral venous blood using Phenol-Chloroform. The genotyping was performed using the Sequenom Mass ARRAY i PLEX genotyping method. The association between genetic polymorphisms and risk of HCC was shown by P-value and the odd ratio(OR) with 95% confidence interval(CI) using the unconditional logistic regression after adjusting for age, sex, nationality, smoking, drinking, family history of HCC, and hepatitis B virus(HBV) infection. Moreover, stratified analysis was conducted on the basis of the status of HBV infection, smoking, and alcohol drinking.RESULTS: The HCC risk was lower in patients with the MCM4 rs2305952 CC(OR = 0.22, 95%CI: 0.08-0.63, P = 0.01) and with the CHEK1 rs515255 TC, TT, TC/TT(OR = 0.73, 95%CI: 0.56-0.96, P = 0.02; OR = 0.67, 95%CI: 0.46-0.97, P = 0.04; OR = 0.72, 95%CI: 0.56-0.92, P = 0.01, respectively). Conversely, the HCC risk was higher in patients with the KAT2 B rs17006625 GG(OR = 1.64, 95%CI: 1.01-2.64, P = 0.04). In addition, the risk was markedly lower for those who were carriers of MCM4 rs2305952 CC and were also HBs Ag-positive and non-drinking and nonsmoking(P < 0.05, respectively) and for those who were carriers of CHEK1 rs515255 TC, TT, TC/TT and were also HBs Ag-negative and non-drinking(P < 0.05, respectively). Moreover, the risk was higher for those who were carriers of KAT2 B rs17006625 GG and were also HBs Ag-negative(P < 0.05).CONCLUSION: Of 12 cell cycle pathway genes, MCM4, CHEK1 and KAT2 B polymorphisms may be associated with the risk of HCC.展开更多
The authors present new paleomagnetic results obtained at the Meishan Permian Triassic (P/T) boundary section, Changxing County, Zhejiang Province. 330 samples in Changxing Group of Permian, 9 samples at P/T boundary...The authors present new paleomagnetic results obtained at the Meishan Permian Triassic (P/T) boundary section, Changxing County, Zhejiang Province. 330 samples in Changxing Group of Permian, 9 samples at P/T boundary, and 25 samples in Qinglong Group of Triassic are studied. Thermal and alternative filed demagnetization isolated a stable magnetization from most samples. This stable magnetization was thought to be acquired at or close to the time of formation of the rocks. The constructed polarity column shows that the bottom of the sampling section is forming a short reversed polarity. Above this short reversed polarity, there is a normal polarity, which lasts about 1.0 Ma. Below this short reversed polarity, are present 6 normal polarities and 7 reversed polarities between the upper Lower Changxing and Upper Changxing Group. Near the P/T boundary, the magnetization polarity transfers from reversal to normal, and the normal polarity may characterize the rest of the section. Susceptibility measurement of 550 samples shows a sharp change at the P/T boundary and a high correspondence with the minor frequency cycle of sedimentary. The spectrum of susceptibility indicates that there are 4 sedimentary cycles during 252-248 Ma in the section.展开更多
目的探索乳腺癌/卵巢癌易感基因1相关蛋白1(breast/ovarian cancer susceptibility gene 1 associated protein 1,BAP1)对人源恶性胶质瘤发生、发展的作用与BAP1作为恶性胶质瘤临床诊断标志物的可行性。方法基于基因表达综合数据库(gene...目的探索乳腺癌/卵巢癌易感基因1相关蛋白1(breast/ovarian cancer susceptibility gene 1 associated protein 1,BAP1)对人源恶性胶质瘤发生、发展的作用与BAP1作为恶性胶质瘤临床诊断标志物的可行性。方法基于基因表达综合数据库(gene expression omnibus,GEO)的子数据集GSE4290,GSE90598,分析BAP1在正常组织及胶质瘤组织中的差异性表达情况;受试者工作特征(receiver operating characteristic,ROC)曲线分析BAP1对恶性胶质瘤的早期诊断价值;选取自主收集的非配对28例恶性胶质瘤患者的原发灶组织、5例颅脑外伤患者内减压术切除的非瘤脑组织,采用实时荧光定量PCR(quantitative real-time polymerase chain reaction,qRT-PCR)检测BAP1的表达水平;利用靶向BAP1的特异性小干扰RNAs(small interfering RNAs,siRNAs)瞬时转染U251细胞系,进一步检测其干涉效率;基于流式细胞仪分析BAP1下调的U251细胞系,其细胞周期、凋亡的变化情况。结果生物信息学结果显示,BAP1在恶性胶质瘤组织中的表达水平均低于正常脑组织(GSE4290:1209±18.49 vs 1476±53.90;GSE90598:5.19±0.10 vs 5.65±0.21),差异具有统计学意义(t=5.115,2.267,均P<0.05)。ROC曲线显示,BAP1可高效区分恶性胶质瘤组织与正常脑组织(GSE4290:AUC=0.78;GSE90598:AUC=0.75,均P<0.05)。临床标本结果显示,BAP1在恶性胶质瘤原发灶组织中的表达水平显著低于非瘤脑组织(0.27±0.04 vs 1.06±0.07),差异具有统计学意义(t=10.22,P<0.001)。在U251细胞系中下调BAP1的表达,其细胞周期中S期细胞比例明显增多,由17.59%分别增至27.21%(siBAP1-1)和25.79%(siBAP1-2),差异具有统计学意义(t=6.576,6.642,均P<0.01),而细胞凋亡水平则有所下降,由10.17%分别降至2.70%(siBAP-1)和3.00%(siBAP-2),差异具有统计学意义(t=10.31,9.428,均P<0.01)。结论组蛋白H2A去泛素化酶BAP1能够通过抑制恶性胶质瘤细胞周期快速进展并促进其凋亡,进而发挥肿瘤抑癌基因的功能,可作为潜在的恶展开更多
The second-order nonlinear optical susceptibilities β, βμ, and third-order non-linear optical susceptibilities γ, 〈γ〉 of a series of the novel push-pull multi-ring electro-photo polymer intermediates have been ...The second-order nonlinear optical susceptibilities β, βμ, and third-order non-linear optical susceptibilities γ, 〈γ〉 of a series of the novel push-pull multi-ring electro-photo polymer intermediates have been calculated. The influences of molecular structure, donor, acceptor and the frequency of external field on β and γ, and the relationship between γ and the number of thiophene rings (i. e. conjugated chain length) have been studied using INDO/SCI methods combined with sum-overstate (SOS) formula. The calculated results show that γ is proportional to 2.69 power of the chain length of the conjugated molecular bonds when the length is not quite long.展开更多
Based on the latest Planck surveys, the universe is close to being remarkably flat, and yet, within observational error, there is still room for a slight curvature. If the curvature is positive, then this would lead t...Based on the latest Planck surveys, the universe is close to being remarkably flat, and yet, within observational error, there is still room for a slight curvature. If the curvature is positive, then this would lead to a closed universe, as well as allow for a big bounce scenario. Working within these assumptions, and using a simple model, we predict that the cosmos may have a positive curvature in the amount, <span style="white-space:nowrap;"><span style="white-space:nowrap;">Ω<sub>0</sub>=1.001802</span></span>, a value within current observational bounds. For the scaling laws associated with the density parameters in Friedmann’s equations, we will assume a susceptibility model for space, where, <img src="Edit_18751d6f-dbfa-47ba-be7c-8298073a34fd.png" alt="" style="white-space:normal;" />, equals the smeared cosmic susceptibility. If we allow the <img src="Edit_18751d6f-dbfa-47ba-be7c-8298073a34fd.png" alt="" /> to <em>decrease with increasing</em> cosmic scale parameter, “<em>a</em>”, then we can predict a maximum Hubble volume, with minimum CMB temperature for the voids, before contraction begins, as well as a minimum volume, with maximum CMB temperature, when expansion starts. A specific heat engine model for the cosmos is also entertained for this model of a closed universe.展开更多
文摘陕西关中盆地的泾阳南塬和西安东郊席王晚更新世黄土剖面底部的S_1古土壤是由4层古土壤及与其相间的3层黄土构成,L_1黄土是由3层黄土及夹于其间的两层古土壤构成。这是目前发现的黄土高原晚更新世黄土-古土壤序列保存较好的剖面。两剖面的地层结构、磁化率曲线和地球化学组分反映出的12个温湿、冷干气候变化阶段可以归纳为6个气候变化旋回。这是目前建立的我国黄土高原晚更新世(130—10ka B P)较短时间尺度的气候变化模式,它与经典的深海氧同位素记录曲线是不相一致的。
基金Supported by National Natural Science Foundation of China,No.81360448Natural Science Foundation of Guangxi,No.2014GXNSFAA118139+1 种基金Fund of Key Laboratory of High Incidence-Tumor Prevention and Treatment(Guangxi Medical University),Ministry of Education,No.GK2015-ZZ03 and No.GK2014-ZZ03Guangxi Outstanding Teacher Training Project for Colleges
文摘AIM: To investigate the associations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma(HCC). METHODS: We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospital of Guangxi Medical University and 1200 non-tumor patients from the First Affiliated Hospital of Guangxi Medical University. General demographic characteristics, behavioral information, and hematological indices were collected by unified questionnaires. Genomic DNA was isolatedfrom peripheral venous blood using Phenol-Chloroform. The genotyping was performed using the Sequenom Mass ARRAY i PLEX genotyping method. The association between genetic polymorphisms and risk of HCC was shown by P-value and the odd ratio(OR) with 95% confidence interval(CI) using the unconditional logistic regression after adjusting for age, sex, nationality, smoking, drinking, family history of HCC, and hepatitis B virus(HBV) infection. Moreover, stratified analysis was conducted on the basis of the status of HBV infection, smoking, and alcohol drinking.RESULTS: The HCC risk was lower in patients with the MCM4 rs2305952 CC(OR = 0.22, 95%CI: 0.08-0.63, P = 0.01) and with the CHEK1 rs515255 TC, TT, TC/TT(OR = 0.73, 95%CI: 0.56-0.96, P = 0.02; OR = 0.67, 95%CI: 0.46-0.97, P = 0.04; OR = 0.72, 95%CI: 0.56-0.92, P = 0.01, respectively). Conversely, the HCC risk was higher in patients with the KAT2 B rs17006625 GG(OR = 1.64, 95%CI: 1.01-2.64, P = 0.04). In addition, the risk was markedly lower for those who were carriers of MCM4 rs2305952 CC and were also HBs Ag-positive and non-drinking and nonsmoking(P < 0.05, respectively) and for those who were carriers of CHEK1 rs515255 TC, TT, TC/TT and were also HBs Ag-negative and non-drinking(P < 0.05, respectively). Moreover, the risk was higher for those who were carriers of KAT2 B rs17006625 GG and were also HBs Ag-negative(P < 0.05).CONCLUSION: Of 12 cell cycle pathway genes, MCM4, CHEK1 and KAT2 B polymorphisms may be associated with the risk of HCC.
基金The study is supported by Geological Profession Foundation from the Ministry of L and and Resources of China( No.95 962 1)
文摘The authors present new paleomagnetic results obtained at the Meishan Permian Triassic (P/T) boundary section, Changxing County, Zhejiang Province. 330 samples in Changxing Group of Permian, 9 samples at P/T boundary, and 25 samples in Qinglong Group of Triassic are studied. Thermal and alternative filed demagnetization isolated a stable magnetization from most samples. This stable magnetization was thought to be acquired at or close to the time of formation of the rocks. The constructed polarity column shows that the bottom of the sampling section is forming a short reversed polarity. Above this short reversed polarity, there is a normal polarity, which lasts about 1.0 Ma. Below this short reversed polarity, are present 6 normal polarities and 7 reversed polarities between the upper Lower Changxing and Upper Changxing Group. Near the P/T boundary, the magnetization polarity transfers from reversal to normal, and the normal polarity may characterize the rest of the section. Susceptibility measurement of 550 samples shows a sharp change at the P/T boundary and a high correspondence with the minor frequency cycle of sedimentary. The spectrum of susceptibility indicates that there are 4 sedimentary cycles during 252-248 Ma in the section.
文摘目的探索乳腺癌/卵巢癌易感基因1相关蛋白1(breast/ovarian cancer susceptibility gene 1 associated protein 1,BAP1)对人源恶性胶质瘤发生、发展的作用与BAP1作为恶性胶质瘤临床诊断标志物的可行性。方法基于基因表达综合数据库(gene expression omnibus,GEO)的子数据集GSE4290,GSE90598,分析BAP1在正常组织及胶质瘤组织中的差异性表达情况;受试者工作特征(receiver operating characteristic,ROC)曲线分析BAP1对恶性胶质瘤的早期诊断价值;选取自主收集的非配对28例恶性胶质瘤患者的原发灶组织、5例颅脑外伤患者内减压术切除的非瘤脑组织,采用实时荧光定量PCR(quantitative real-time polymerase chain reaction,qRT-PCR)检测BAP1的表达水平;利用靶向BAP1的特异性小干扰RNAs(small interfering RNAs,siRNAs)瞬时转染U251细胞系,进一步检测其干涉效率;基于流式细胞仪分析BAP1下调的U251细胞系,其细胞周期、凋亡的变化情况。结果生物信息学结果显示,BAP1在恶性胶质瘤组织中的表达水平均低于正常脑组织(GSE4290:1209±18.49 vs 1476±53.90;GSE90598:5.19±0.10 vs 5.65±0.21),差异具有统计学意义(t=5.115,2.267,均P<0.05)。ROC曲线显示,BAP1可高效区分恶性胶质瘤组织与正常脑组织(GSE4290:AUC=0.78;GSE90598:AUC=0.75,均P<0.05)。临床标本结果显示,BAP1在恶性胶质瘤原发灶组织中的表达水平显著低于非瘤脑组织(0.27±0.04 vs 1.06±0.07),差异具有统计学意义(t=10.22,P<0.001)。在U251细胞系中下调BAP1的表达,其细胞周期中S期细胞比例明显增多,由17.59%分别增至27.21%(siBAP1-1)和25.79%(siBAP1-2),差异具有统计学意义(t=6.576,6.642,均P<0.01),而细胞凋亡水平则有所下降,由10.17%分别降至2.70%(siBAP-1)和3.00%(siBAP-2),差异具有统计学意义(t=10.31,9.428,均P<0.01)。结论组蛋白H2A去泛素化酶BAP1能够通过抑制恶性胶质瘤细胞周期快速进展并促进其凋亡,进而发挥肿瘤抑癌基因的功能,可作为潜在的恶
基金Project supported by the National Natural Science Foundation of China (No. 29890210)
文摘The second-order nonlinear optical susceptibilities β, βμ, and third-order non-linear optical susceptibilities γ, 〈γ〉 of a series of the novel push-pull multi-ring electro-photo polymer intermediates have been calculated. The influences of molecular structure, donor, acceptor and the frequency of external field on β and γ, and the relationship between γ and the number of thiophene rings (i. e. conjugated chain length) have been studied using INDO/SCI methods combined with sum-overstate (SOS) formula. The calculated results show that γ is proportional to 2.69 power of the chain length of the conjugated molecular bonds when the length is not quite long.
文摘Based on the latest Planck surveys, the universe is close to being remarkably flat, and yet, within observational error, there is still room for a slight curvature. If the curvature is positive, then this would lead to a closed universe, as well as allow for a big bounce scenario. Working within these assumptions, and using a simple model, we predict that the cosmos may have a positive curvature in the amount, <span style="white-space:nowrap;"><span style="white-space:nowrap;">Ω<sub>0</sub>=1.001802</span></span>, a value within current observational bounds. For the scaling laws associated with the density parameters in Friedmann’s equations, we will assume a susceptibility model for space, where, <img src="Edit_18751d6f-dbfa-47ba-be7c-8298073a34fd.png" alt="" style="white-space:normal;" />, equals the smeared cosmic susceptibility. If we allow the <img src="Edit_18751d6f-dbfa-47ba-be7c-8298073a34fd.png" alt="" /> to <em>decrease with increasing</em> cosmic scale parameter, “<em>a</em>”, then we can predict a maximum Hubble volume, with minimum CMB temperature for the voids, before contraction begins, as well as a minimum volume, with maximum CMB temperature, when expansion starts. A specific heat engine model for the cosmos is also entertained for this model of a closed universe.
