The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine t...The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.展开更多
The Zeolite Y as a support was modified by the incorporating of Fe and TiO2 in one single step using impregnation method. The synergistic effects between those components enhance the catalytic activity for the degrada...The Zeolite Y as a support was modified by the incorporating of Fe and TiO2 in one single step using impregnation method. The synergistic effects between those components enhance the catalytic activity for the degradation of amaranth dye under ultrasonic irradiation with output power of 50 W and 40 kHz frequency. Different characterization techniques were used to elucidate the physical and chemical properties of the produced catalysts. The XRD results indicated that the type of titanium precursor significantly effects on the crystallinity of 0.4% Fe/15%TiO2-NaY catalyst. The AFM results detected that the TiO2 formed a layer covered the surface of zeolite while Fe clusters were located close to TiO2. The influence of reaction parameters such as TiO2 and Fe content, pH values, amount of hydrogen peroxide used, catalyst loading and the initial dye concentration were investigated for the decolorization efficiency of amaranth. The maximum decolorization efficiency for 0.4%Fe/15%TiO2-NaY was 100% after 120 min of reaction time with an initial dye concentration of 30 mg/L, 2 g/L of catalyst loading, natural pH about 5.5 and 0.65 mM H2O2.展开更多
In the present investigation, we fabricated strontium (Sr2+) incorporated CsPbI2Br-based inorganic perovskite solar cells in ambient conditions. The morphology, crystallinity, absorption, elemental composition and pho...In the present investigation, we fabricated strontium (Sr2+) incorporated CsPbI2Br-based inorganic perovskite solar cells in ambient conditions. The morphology, crystallinity, absorption, elemental composition and photoluminescence analysis of the bare CsPbI2Br and CsPb1-xSrxI2Br perovskite thin films were studied systematically to investigate the role of Sr2+ incorporation. It is observed that the surface morphology of the CsPbI2Br perovskite thin film has been improved by partial substitution of Pb2+ by Sr2+ which facilitates photoactive black phase-stabilization and defect passivation. The champion device having CsPb0.98Sr0.02I2Br composition exhibited a power conversion efficiency (PCE) of 16.61% which is much higher than the bare device (13.65%). Furthermore, our CsPb0.98Sr0.02I2Br-based devices maintain > 85% of its initial efficiency over 100 h in ambient conditions.展开更多
Reporting modeling results with uncertainty information can benefit decision making by decreasing the extent that variability exerts a disproportionate influence on the options selected. For making decisions with more...Reporting modeling results with uncertainty information can benefit decision making by decreasing the extent that variability exerts a disproportionate influence on the options selected. For making decisions with more confidence, the uncertainty interval should be as narrow as possible. Here, the soil organic carbon （SOC） dynamics of the major paddy soil subgroup from 4 different paddy field regions of China （located in 4 counties under different climate-soil-management combinations） were modeled using the DeNitrification- DeComposition （DNDC） model for the period from 1980 to 2008. Uncertainty intervals associated with the SOC dynamics for these 4 subgroups were estimated by a long-term global sensitivity and uncertainty analysis （i. e., the Sobolt method）, and their sensitivities to 7 influential factors were quantified using the total effect sensitivity index. The results, modeled with high confidence, indicated that in the past 29 years, the studied paddy soils in Xinxing, Yixing, and Zhongjiang counties were carbon （C） sinks, while the paddy soil in Helong County was a C source. The 3 C sinks sequestered 12.2 （5.4, 19.6）, 17.1 （8.9, 25.0）, and 16.9 （-1.2, 33.6） t C ha-1 （values in the parentheses are the 5th and 95th percentiles, respectively）. Conversely, the C source had a loss of -5.4 （-14.2, 0.06） t C ha-1 in the past 29 years. The 7 factors, which changed with the climate-soil-management context, exhibited variable influences on modeled SOC. Measures with potential to conserve or sequestrate more C into paddy soils, such as incorporating more crop residues into soils and reducing chemical fertilizer application rates, were recommended for specific soils based on the sensitivity analysis results.展开更多
文摘The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.
文摘The Zeolite Y as a support was modified by the incorporating of Fe and TiO2 in one single step using impregnation method. The synergistic effects between those components enhance the catalytic activity for the degradation of amaranth dye under ultrasonic irradiation with output power of 50 W and 40 kHz frequency. Different characterization techniques were used to elucidate the physical and chemical properties of the produced catalysts. The XRD results indicated that the type of titanium precursor significantly effects on the crystallinity of 0.4% Fe/15%TiO2-NaY catalyst. The AFM results detected that the TiO2 formed a layer covered the surface of zeolite while Fe clusters were located close to TiO2. The influence of reaction parameters such as TiO2 and Fe content, pH values, amount of hydrogen peroxide used, catalyst loading and the initial dye concentration were investigated for the decolorization efficiency of amaranth. The maximum decolorization efficiency for 0.4%Fe/15%TiO2-NaY was 100% after 120 min of reaction time with an initial dye concentration of 30 mg/L, 2 g/L of catalyst loading, natural pH about 5.5 and 0.65 mM H2O2.
基金This work was supported by Priority Research Centre Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science,and Technology(NRF-2018R1A6A1A03024334)Also,this work was supported by Priority Research Centre Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science,and Technology(2020R1A2C2004880).
文摘In the present investigation, we fabricated strontium (Sr2+) incorporated CsPbI2Br-based inorganic perovskite solar cells in ambient conditions. The morphology, crystallinity, absorption, elemental composition and photoluminescence analysis of the bare CsPbI2Br and CsPb1-xSrxI2Br perovskite thin films were studied systematically to investigate the role of Sr2+ incorporation. It is observed that the surface morphology of the CsPbI2Br perovskite thin film has been improved by partial substitution of Pb2+ by Sr2+ which facilitates photoactive black phase-stabilization and defect passivation. The champion device having CsPb0.98Sr0.02I2Br composition exhibited a power conversion efficiency (PCE) of 16.61% which is much higher than the bare device (13.65%). Furthermore, our CsPb0.98Sr0.02I2Br-based devices maintain > 85% of its initial efficiency over 100 h in ambient conditions.
基金supported by the National Natural Science Foundation of China (No.41471177)the Knowledge Innovation Program of Chinese Academy of Sciences (No.KZCX2-EW-QN404)the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDA05050509)
文摘Reporting modeling results with uncertainty information can benefit decision making by decreasing the extent that variability exerts a disproportionate influence on the options selected. For making decisions with more confidence, the uncertainty interval should be as narrow as possible. Here, the soil organic carbon （SOC） dynamics of the major paddy soil subgroup from 4 different paddy field regions of China （located in 4 counties under different climate-soil-management combinations） were modeled using the DeNitrification- DeComposition （DNDC） model for the period from 1980 to 2008. Uncertainty intervals associated with the SOC dynamics for these 4 subgroups were estimated by a long-term global sensitivity and uncertainty analysis （i. e., the Sobolt method）, and their sensitivities to 7 influential factors were quantified using the total effect sensitivity index. The results, modeled with high confidence, indicated that in the past 29 years, the studied paddy soils in Xinxing, Yixing, and Zhongjiang counties were carbon （C） sinks, while the paddy soil in Helong County was a C source. The 3 C sinks sequestered 12.2 （5.4, 19.6）, 17.1 （8.9, 25.0）, and 16.9 （-1.2, 33.6） t C ha-1 （values in the parentheses are the 5th and 95th percentiles, respectively）. Conversely, the C source had a loss of -5.4 （-14.2, 0.06） t C ha-1 in the past 29 years. The 7 factors, which changed with the climate-soil-management context, exhibited variable influences on modeled SOC. Measures with potential to conserve or sequestrate more C into paddy soils, such as incorporating more crop residues into soils and reducing chemical fertilizer application rates, were recommended for specific soils based on the sensitivity analysis results.
