Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophy...Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS.展开更多
Three degrees of freedom （3-DOF） Helmholtz resonator which consists of three cylindrical necks and cavities connected in series （neck-cavity-neck-cavity-neck-cavity） is suitable to reduce flow pulsation in hydraul...Three degrees of freedom （3-DOF） Helmholtz resonator which consists of three cylindrical necks and cavities connected in series （neck-cavity-neck-cavity-neck-cavity） is suitable to reduce flow pulsation in hydraulic system. A novel lumped parameter model （LPM） of 3-DOF Helmholtz resonator in hydraulic system is developed which considers the viscous friction loss of hy- draulic fluid in the necks. Applying the Newton＇s second law of motion to the equivalent mechanical model of the resonator, closed-form expression of transmission loss and resonance frequency is presented. Based on the LPM, an optimal design method which employs rotate vector optimization method （RVOM） is proposed. The purpose of the optimal design is to search the reso- nator＇s unknown parameters so that its resonance frequencies can coincide with the pump-induced flow pulsation harmonics respectively. The optimal design method is realized to design 3-DOF Helmholtz resonator for a certain type of aviation piston pump hydraulic system. The optimization result shows the feasibility of this method, and the simulation under optimum parame- ters reveals that the LPM can get the same precision as transfer matrix method （TMM）.展开更多
Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were...Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were extracted from fermented and non-fermented L.edodes and purified via DEAE-52 and Sephadex G-100.The components designated F-LEP-2a and NF-LEP-2a were analyzed by FT-IR,HPGPC,HPAEC,SEM,GC-MS and NMR.The results revealed that probiotic fermentation increased the molecular weight from 1.16×10^(4) Da to 1.87×10^(4) Da and altered the proportions of glucose,galactose and mannose,in which glucose increased from 45.94%to 48.16%.Methylation analysis and NMR spectra indicated that F-LEP-2a and NF-LEP-2a had similar linkage patterns.Furthermore,their immunomodulatory activities were evaluated with immunosuppressive mice.NF-LEP and F-LEP improved immune organ indices,immunoglobulin(Ig G and Ig M)and cytokines concentrations;restored the antioxidation capacity of liver;and maintained the balance of gut microbiota.F-LEP displayed better moderating effects on the spleen index,immunoglobulin,cytokines and the diversity of gut microbiota than NF-LEP(200,400 mg/kg).Our study provides an efficient and environment-friendly way for the structural modification of polysaccharides,which helps to enhance their biological activity and promote their wide application in food,medicine and other fields.展开更多
Application of nondestructive techniques combined with image processing techniques has been increasing in investigating the internal structure of food products.Magnetic resonance imaging(MRI)is one of these methods.Th...Application of nondestructive techniques combined with image processing techniques has been increasing in investigating the internal structure of food products.Magnetic resonance imaging(MRI)is one of these methods.The aim of this research is to investigate the effect of coating formulation on structural properties of turkey nugget samples(turkey nugget with typical batter,tragacanth-containing batter and tragacanth)by MRI.Results revealed that the changes caused by the batter formulation could also be examined using the tomographic images.The results also indicated that the brightness of the MRI images of the nugget core and crust decreased during frying.The core of the nugget with the tragacanth-containing batter was brighter revealing its higher moisture content.Furthermore,the nugget core was less reduced in this sample compared with the other ones.This research aimed to present a valuable knowledge about nugget frying pertaining to quality evaluation.展开更多
基金Supported by the Spanish Ministry of Science and Innovation(MICINN,Spain),No.AGL2017-88801-P(to Sanz Y)the Miguel Server grant from the Spanish"Carlos III"Health Institute(ISCIII),No.CP19/00132(to Benitez-Paez A)+2 种基金The Norwegian Research Council(Funding Postdoc Position for Bharath Halandur Nagaraja),No.FRIMEDBIO276010and Helse Vest’s Research Funding,No.HV912243and ERC H2020-MSCA-IF-2019,No.895219(to Haleem N).
文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS.
基金National Science Fund for Distinguished Young Scholars (50825502)
文摘Three degrees of freedom （3-DOF） Helmholtz resonator which consists of three cylindrical necks and cavities connected in series （neck-cavity-neck-cavity-neck-cavity） is suitable to reduce flow pulsation in hydraulic system. A novel lumped parameter model （LPM） of 3-DOF Helmholtz resonator in hydraulic system is developed which considers the viscous friction loss of hy- draulic fluid in the necks. Applying the Newton＇s second law of motion to the equivalent mechanical model of the resonator, closed-form expression of transmission loss and resonance frequency is presented. Based on the LPM, an optimal design method which employs rotate vector optimization method （RVOM） is proposed. The purpose of the optimal design is to search the reso- nator＇s unknown parameters so that its resonance frequencies can coincide with the pump-induced flow pulsation harmonics respectively. The optimal design method is realized to design 3-DOF Helmholtz resonator for a certain type of aviation piston pump hydraulic system. The optimization result shows the feasibility of this method, and the simulation under optimum parame- ters reveals that the LPM can get the same precision as transfer matrix method （TMM）.
基金supported by grants from the National Key R&D Program of China(2019YFC1606701)。
文摘Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were extracted from fermented and non-fermented L.edodes and purified via DEAE-52 and Sephadex G-100.The components designated F-LEP-2a and NF-LEP-2a were analyzed by FT-IR,HPGPC,HPAEC,SEM,GC-MS and NMR.The results revealed that probiotic fermentation increased the molecular weight from 1.16×10^(4) Da to 1.87×10^(4) Da and altered the proportions of glucose,galactose and mannose,in which glucose increased from 45.94%to 48.16%.Methylation analysis and NMR spectra indicated that F-LEP-2a and NF-LEP-2a had similar linkage patterns.Furthermore,their immunomodulatory activities were evaluated with immunosuppressive mice.NF-LEP and F-LEP improved immune organ indices,immunoglobulin(Ig G and Ig M)and cytokines concentrations;restored the antioxidation capacity of liver;and maintained the balance of gut microbiota.F-LEP displayed better moderating effects on the spleen index,immunoglobulin,cytokines and the diversity of gut microbiota than NF-LEP(200,400 mg/kg).Our study provides an efficient and environment-friendly way for the structural modification of polysaccharides,which helps to enhance their biological activity and promote their wide application in food,medicine and other fields.
文摘Application of nondestructive techniques combined with image processing techniques has been increasing in investigating the internal structure of food products.Magnetic resonance imaging(MRI)is one of these methods.The aim of this research is to investigate the effect of coating formulation on structural properties of turkey nugget samples(turkey nugget with typical batter,tragacanth-containing batter and tragacanth)by MRI.Results revealed that the changes caused by the batter formulation could also be examined using the tomographic images.The results also indicated that the brightness of the MRI images of the nugget core and crust decreased during frying.The core of the nugget with the tragacanth-containing batter was brighter revealing its higher moisture content.Furthermore,the nugget core was less reduced in this sample compared with the other ones.This research aimed to present a valuable knowledge about nugget frying pertaining to quality evaluation.
