To the Editor:Vitiligo is an acquired chronic depigrnentation disorder of the skin resulting from selective destruction of melanocytes.Although it is not a life-threatening disease,it may lead to disfigurement and is ...To the Editor:Vitiligo is an acquired chronic depigrnentation disorder of the skin resulting from selective destruction of melanocytes.Although it is not a life-threatening disease,it may lead to disfigurement and is associated with many other autoimmune diseases.According to a recent international consensus conference,vitiIigo can be cIassified into two major forms: nonsegmental vitiligo (NSV)and segmental vitiligo (SV,accounts for 5-16% of all vitiligo cases).NSV typically evolves over time, in both distribution and extension patterns,including acrofacial, generalized,mucosal,and facial vitiligo [Figure 1a and 1b].SV is relatively rare and is characterized by unilateral or banded distribution along the ganglion segment.SV usually has an early onset and spreads rapidly in the affected dermatomal area,including single SV,double SV,and the multi-SV [Figure 1c and 1d].展开更多
Vitiligo is a common pigmentary disorder. Many studies across decades and all over the world have attempted to illustrate the pathogenesis behind it; however, the pathogenesis of vitiligo remains elusive. This review ...Vitiligo is a common pigmentary disorder. Many studies across decades and all over the world have attempted to illustrate the pathogenesis behind it; however, the pathogenesis of vitiligo remains elusive. This review article, we present the findings behind the most and updated theories behind this psychologically debilitating and disfiguring disease. The discussion begun with the role of genetic predisposition followed by neural theory first proposed in the 1950 s. Wehighlight the autoimmune hypothesis, followed by the reactive oxygen species model, zinc-α2-glycoprotein deficiency hypothesis, viral theory, intrinsic theory and biochemical, molecular and cellular alterations accounting for loss of functioning melanocytes in vitiligo. Many theories were elaborated to clarify vitiligo pathogenesis. It is a multifactorial disease involving the interplay of several factors. Future research is needed to clarify the interaction of these factors for better understanding of vitiligo pathogenesis and subsequent successful treatment.展开更多
基金a grant from the National Natural Science Foundation of China (No.81773306).
文摘To the Editor:Vitiligo is an acquired chronic depigrnentation disorder of the skin resulting from selective destruction of melanocytes.Although it is not a life-threatening disease,it may lead to disfigurement and is associated with many other autoimmune diseases.According to a recent international consensus conference,vitiIigo can be cIassified into two major forms: nonsegmental vitiligo (NSV)and segmental vitiligo (SV,accounts for 5-16% of all vitiligo cases).NSV typically evolves over time, in both distribution and extension patterns,including acrofacial, generalized,mucosal,and facial vitiligo [Figure 1a and 1b].SV is relatively rare and is characterized by unilateral or banded distribution along the ganglion segment.SV usually has an early onset and spreads rapidly in the affected dermatomal area,including single SV,double SV,and the multi-SV [Figure 1c and 1d].
文摘Vitiligo is a common pigmentary disorder. Many studies across decades and all over the world have attempted to illustrate the pathogenesis behind it; however, the pathogenesis of vitiligo remains elusive. This review article, we present the findings behind the most and updated theories behind this psychologically debilitating and disfiguring disease. The discussion begun with the role of genetic predisposition followed by neural theory first proposed in the 1950 s. Wehighlight the autoimmune hypothesis, followed by the reactive oxygen species model, zinc-α2-glycoprotein deficiency hypothesis, viral theory, intrinsic theory and biochemical, molecular and cellular alterations accounting for loss of functioning melanocytes in vitiligo. Many theories were elaborated to clarify vitiligo pathogenesis. It is a multifactorial disease involving the interplay of several factors. Future research is needed to clarify the interaction of these factors for better understanding of vitiligo pathogenesis and subsequent successful treatment.
