AIM: To evaluate a new balloon-expandable stainless steel stent (Cordis stent) in a transjugular intrahepatic portosystemic shunt (TIPS) porcine model and compared with Wallstent. METHODS: TIPS was performed in 26 nor...AIM: To evaluate a new balloon-expandable stainless steel stent (Cordis stent) in a transjugular intrahepatic portosystemic shunt (TIPS) porcine model and compared with Wallstent. METHODS: TIPS was performed in 26 normal domestic pigs weighing 20 kg-30 kg using a Cordis stent or Wallstent (13 pigs in each stent). All pigs were sacrificed at the 14th day after TIPS. The stent deployment delivery system, stent patency, and stent recoil after placement were evaluated.Proliferative response in representative histological sections from the center,hepatic and portal regions of the two stent designs were quantified. RESULTS: The shunt was widely patent in 4 pigs in the Cordis stent group (4/12, premature dead in 1 pig), and in 5 pigs in the Wallstent group (5/13). All remaining stents of both designs were occluded or stenotic. The mean quantified proliferation including thickness of the proliferation and the ratio of proliferation: total area in three assayed regions in Cordis stent and Wallstent was 2.18 mm:2.00 mm, and 59.18 mm2:51.66 mm2, respectively (P 】 0.05). The delivery system and mechanical properties of the Cordis stent functioned well. CONCLUSION: The new Cordis stent is appropriate for TIPS procedure.展开更多
目的探讨应用新型 Y 形气道覆膜金属支架输送释放系统,治疗气管分叉区域(包括气管下端、气管隆突和左、右主支气管)狭窄的可行性及临床效果。方法 15例气管分叉区域多发狭窄患者,在 X 线透视下,用新型 Y 形气道覆膜金属支架输送释放系...目的探讨应用新型 Y 形气道覆膜金属支架输送释放系统,治疗气管分叉区域(包括气管下端、气管隆突和左、右主支气管)狭窄的可行性及临床效果。方法 15例气管分叉区域多发狭窄患者,在 X 线透视下,用新型 Y 形气道覆膜金属支架输送释放系统治疗。所用新型 Y 形支架输送释放系统由外到内主要由外鞘管、输送导管和内部并行排列的4根空芯管组成。4根空芯管中,2根为走行导丝的长管、2根为走行支架捆绑线的短管。2根捆绑线分别将 Y 形支架左右主支气管部捆绑成释放前的压缩状并固定于2根长管头端的外表面,然后捆绑线经支架气管部分别走行入2短管至短管尾端外。结果 15例患者使用新型 Y 形气道覆膜金属支架输送释放系统,支架置入均一次性成功,术后所有患者呼吸困难即刻缓解,未出现与手术有关的并发症;生活质量评分由术前26%～45%上升到术后1周的72%～95%。术后临床随访3～58周,中位数22周,所有患者支架置入后全身一般状况得到明显改善;5例患者分别于术后3～42周死亡,但未发生气管分叉部再狭窄;10例继续进行后续治疗者无呼吸困难。结论用新型 Y 形气道覆膜金属支架输送释放系统,治疗气管分叉区域狭窄,技术操作简单安全,并且临床短期疗效较好。展开更多
文摘AIM: To evaluate a new balloon-expandable stainless steel stent (Cordis stent) in a transjugular intrahepatic portosystemic shunt (TIPS) porcine model and compared with Wallstent. METHODS: TIPS was performed in 26 normal domestic pigs weighing 20 kg-30 kg using a Cordis stent or Wallstent (13 pigs in each stent). All pigs were sacrificed at the 14th day after TIPS. The stent deployment delivery system, stent patency, and stent recoil after placement were evaluated.Proliferative response in representative histological sections from the center,hepatic and portal regions of the two stent designs were quantified. RESULTS: The shunt was widely patent in 4 pigs in the Cordis stent group (4/12, premature dead in 1 pig), and in 5 pigs in the Wallstent group (5/13). All remaining stents of both designs were occluded or stenotic. The mean quantified proliferation including thickness of the proliferation and the ratio of proliferation: total area in three assayed regions in Cordis stent and Wallstent was 2.18 mm:2.00 mm, and 59.18 mm2:51.66 mm2, respectively (P 】 0.05). The delivery system and mechanical properties of the Cordis stent functioned well. CONCLUSION: The new Cordis stent is appropriate for TIPS procedure.
文摘目的探讨应用新型 Y 形气道覆膜金属支架输送释放系统,治疗气管分叉区域(包括气管下端、气管隆突和左、右主支气管)狭窄的可行性及临床效果。方法 15例气管分叉区域多发狭窄患者,在 X 线透视下,用新型 Y 形气道覆膜金属支架输送释放系统治疗。所用新型 Y 形支架输送释放系统由外到内主要由外鞘管、输送导管和内部并行排列的4根空芯管组成。4根空芯管中,2根为走行导丝的长管、2根为走行支架捆绑线的短管。2根捆绑线分别将 Y 形支架左右主支气管部捆绑成释放前的压缩状并固定于2根长管头端的外表面,然后捆绑线经支架气管部分别走行入2短管至短管尾端外。结果 15例患者使用新型 Y 形气道覆膜金属支架输送释放系统,支架置入均一次性成功,术后所有患者呼吸困难即刻缓解,未出现与手术有关的并发症;生活质量评分由术前26%～45%上升到术后1周的72%～95%。术后临床随访3～58周,中位数22周,所有患者支架置入后全身一般状况得到明显改善;5例患者分别于术后3～42周死亡,但未发生气管分叉部再狭窄;10例继续进行后续治疗者无呼吸困难。结论用新型 Y 形气道覆膜金属支架输送释放系统,治疗气管分叉区域狭窄,技术操作简单安全,并且临床短期疗效较好。
