目的 分析维生素D受体基因多态性与肺结核易感性的病例对照研究的结果。方法应用Meta—analysis，以Fleiss模型和DerSimonian and Nan Laird模型（D—L模型）对6项研究结果进行数据处理。结果累计病例841例，对照1419例，采用Fleiss模...目的 分析维生素D受体基因多态性与肺结核易感性的病例对照研究的结果。方法应用Meta—analysis，以Fleiss模型和DerSimonian and Nan Laird模型（D—L模型）对6项研究结果进行数据处理。结果累计病例841例，对照1419例，采用Fleiss模型计算的合并OR值ff vs FF为1．20（0．84-1．71），Ff vs FF为0．99（0．81～1.21），D—L模型计算的合并OR值ff vs FF为1．12（0．67-1．86），Ff vs FF为0．99（0．80-1.23）。失效安全数小于1。结论尚不能认为维生素D受体基因多态性是肺结核易感性的影响因素。展开更多
In the past few years,a variety of extradigestive disorders, including cardiovascular,skin,rheumatic and liver diseases, have been associated with Helicobacter pylori(H.pylori) infection.The activation of inflammatory...In the past few years,a variety of extradigestive disorders, including cardiovascular,skin,rheumatic and liver diseases, have been associated with Helicobacter pylori(H.pylori) infection.The activation of inflammatory mediators by H.pylori seems to be the pathogenetic mechanism underlying the observed associations.The present review summarizes the current literature,including our own studies,concerning the association between H.pyloriinfection and respiratory diseases. A small number of epidemiological and serologic,case- control studies suggest that H.pylori infection may be associated with the development of chronic bronchitis.A frequent coexistence of pulmonary tuberculosis and H.pylori infection has also been found.Moreover,recent studies have shown an increased H.pyloriseroprevalence in patients with bronchiectasis and in those with lung cancer.On the other hand,bronchial asthma seems not to be related with H.pylori infection. All associations between H.pylori infection and respiratory diseases are primarily based on case-control studies, concerning relatively small numbers of patients.Moreover, there is a lack of studies focused on the pathogenetic link between respiratory diseases and H.pylori infection. Therefore,we believe that larger studies should be undertaken to confirm the observed results and to clarify the underlying pathogenetic mechanisms.展开更多
目的评价经纤维支气管镜肺活检(transbronch ial lung b iopsy,TBLB)及刷检(brush b iopsy,BB)对肺部周围性占位病变的诊断价值。方法回顾性分析186例X线或CT发现肺部周围性占位患者,经细胞学、组织病理及临床证实最终确诊为肺癌128例...目的评价经纤维支气管镜肺活检(transbronch ial lung b iopsy,TBLB)及刷检(brush b iopsy,BB)对肺部周围性占位病变的诊断价值。方法回顾性分析186例X线或CT发现肺部周围性占位患者,经细胞学、组织病理及临床证实最终确诊为肺癌128例、结核31例、非特异性炎症及其它疾病27例,对其TBLB及BB结果进行分析,了解TBLB、BB病理取材方法的诊断阳性率。结果186例患者中采用TBLB、BB、TBLB+BB对肺癌和肺结核的检出阳性例数和阳性率分别为,肺癌57(44.5%)、27(21.1%)、63(49.2%),结核13(41.9%)、7(22.6%)、15(48.4%)。结论经纤维支气管镜肺活检及刷检对肺部周围性占位病变是安全、可靠、方便、经济并可重复进行的诊断方法。展开更多
文摘目的 分析维生素D受体基因多态性与肺结核易感性的病例对照研究的结果。方法应用Meta—analysis，以Fleiss模型和DerSimonian and Nan Laird模型（D—L模型）对6项研究结果进行数据处理。结果累计病例841例，对照1419例，采用Fleiss模型计算的合并OR值ff vs FF为1．20（0．84-1．71），Ff vs FF为0．99（0．81～1.21），D—L模型计算的合并OR值ff vs FF为1．12（0．67-1．86），Ff vs FF为0．99（0．80-1.23）。失效安全数小于1。结论尚不能认为维生素D受体基因多态性是肺结核易感性的影响因素。
文摘In the past few years,a variety of extradigestive disorders, including cardiovascular,skin,rheumatic and liver diseases, have been associated with Helicobacter pylori(H.pylori) infection.The activation of inflammatory mediators by H.pylori seems to be the pathogenetic mechanism underlying the observed associations.The present review summarizes the current literature,including our own studies,concerning the association between H.pyloriinfection and respiratory diseases. A small number of epidemiological and serologic,case- control studies suggest that H.pylori infection may be associated with the development of chronic bronchitis.A frequent coexistence of pulmonary tuberculosis and H.pylori infection has also been found.Moreover,recent studies have shown an increased H.pyloriseroprevalence in patients with bronchiectasis and in those with lung cancer.On the other hand,bronchial asthma seems not to be related with H.pylori infection. All associations between H.pylori infection and respiratory diseases are primarily based on case-control studies, concerning relatively small numbers of patients.Moreover, there is a lack of studies focused on the pathogenetic link between respiratory diseases and H.pylori infection. Therefore,we believe that larger studies should be undertaken to confirm the observed results and to clarify the underlying pathogenetic mechanisms.
文摘目的评价经纤维支气管镜肺活检(transbronch ial lung b iopsy,TBLB)及刷检(brush b iopsy,BB)对肺部周围性占位病变的诊断价值。方法回顾性分析186例X线或CT发现肺部周围性占位患者,经细胞学、组织病理及临床证实最终确诊为肺癌128例、结核31例、非特异性炎症及其它疾病27例,对其TBLB及BB结果进行分析,了解TBLB、BB病理取材方法的诊断阳性率。结果186例患者中采用TBLB、BB、TBLB+BB对肺癌和肺结核的检出阳性例数和阳性率分别为,肺癌57(44.5%)、27(21.1%)、63(49.2%),结核13(41.9%)、7(22.6%)、15(48.4%)。结论经纤维支气管镜肺活检及刷检对肺部周围性占位病变是安全、可靠、方便、经济并可重复进行的诊断方法。
