AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 pat...AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 patients were enrolled in a phase Ⅱ study on the treatment of loco-regionally advanced esophageal cancer with radiotherapy(68.4 Gy/44 fractions or 61.2 Gy/34 fractions) combined with 4-cycle chemotherapy consisting of DDP(25 mg/m^2 per day for 3 d) and PTX(175 mg/m^2 for 3 h). The primary endpoints were overall survival and progression-free survival, and the secondary endpoints were toxicity and the treatment failure pattern.RESULTS A total of 76 patients were enrolled in this study, of whom 63.2% finished the whole regimen. The 5-year survival rates for the per-protocol population and intent-to-treat population were 25.4% and 26.4%, respectively, and the median survival rates were 23.7 mo and 28.5 mo, respectively. Grade 3 or 4 late toxicity was observed in only one patient(heart failure). In log-rank analysis, the pretreatment stage(stage Ⅱ + Ⅲ: 36.1 mo vs stage Ⅳ: 14.9 mo) and the completed cycle(1-3 cycles: 16.1 mo vs 4 cycles: 35.5 mo) were significant prognostic factors(P = 0.037 < 0.05 and P = 0.013 < 0.05).CONCLUSION Radiotherapy combined with chemotherapy consisting of PTX and DDP is a safe and effective definitive treatment for loco-regionally advanced esophageal squamous cancer.展开更多
In 1957, Brantigan applied lung volume reduction surgery （LVRS） to the treatment of emphysema. In 1995, Cooper reused this operation and obtained remarkable benefit in patients with chronic obstructive pulmonary dis...In 1957, Brantigan applied lung volume reduction surgery （LVRS） to the treatment of emphysema. In 1995, Cooper reused this operation and obtained remarkable benefit in patients with chronic obstructive pulmonary disease （COPD）. Although there are still some doubts about the effect of LVRS, in the past 10 years, a lot of clinical information approved that LVRS can give benefit to more than 70% of COPD patients. At present, a series of researches in long-term investigation and function evaluation such as NETT have got elementary affirmative conclusion about some disputative problems.展开更多
国际器官移植协会（The Transplantation Society，TIS）举办的第24届国际器官移植大会（24th International Congress of the Transplantation Society，24th ICTS）于2012年7月15-19日在德国柏林召开。来自英国达特茅斯Geisel医学院的...国际器官移植协会（The Transplantation Society，TIS）举办的第24届国际器官移植大会（24th International Congress of the Transplantation Society，24th ICTS）于2012年7月15-19日在德国柏林召开。来自英国达特茅斯Geisel医学院的RichardB．Freeman教授在大会发言中作了题为“实体器官移植长期效果”的专题演讲，依据国际上大范围、大样本的登记处资料以及相关的数据分析和研究，重点关注肾、肝、心脏移植等大器官移植10年或更长时间的疗效，对实体器官移植的现状、进展和存在的问题进行了总结。我们将Freeman教授报告的内容编译、整理为受者及移植物的长期存活情况、影响实体器官移植长期效果的因素、改善受者健康相关生活质量及移植物功能三部分内容，供国内移植同道们学习、交流。展开更多
基金Supported by National Natural Science Foundation of China,No.21172043 and No.21441010
文摘AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 patients were enrolled in a phase Ⅱ study on the treatment of loco-regionally advanced esophageal cancer with radiotherapy(68.4 Gy/44 fractions or 61.2 Gy/34 fractions) combined with 4-cycle chemotherapy consisting of DDP(25 mg/m^2 per day for 3 d) and PTX(175 mg/m^2 for 3 h). The primary endpoints were overall survival and progression-free survival, and the secondary endpoints were toxicity and the treatment failure pattern.RESULTS A total of 76 patients were enrolled in this study, of whom 63.2% finished the whole regimen. The 5-year survival rates for the per-protocol population and intent-to-treat population were 25.4% and 26.4%, respectively, and the median survival rates were 23.7 mo and 28.5 mo, respectively. Grade 3 or 4 late toxicity was observed in only one patient(heart failure). In log-rank analysis, the pretreatment stage(stage Ⅱ + Ⅲ: 36.1 mo vs stage Ⅳ: 14.9 mo) and the completed cycle(1-3 cycles: 16.1 mo vs 4 cycles: 35.5 mo) were significant prognostic factors(P = 0.037 < 0.05 and P = 0.013 < 0.05).CONCLUSION Radiotherapy combined with chemotherapy consisting of PTX and DDP is a safe and effective definitive treatment for loco-regionally advanced esophageal squamous cancer.
文摘In 1957, Brantigan applied lung volume reduction surgery （LVRS） to the treatment of emphysema. In 1995, Cooper reused this operation and obtained remarkable benefit in patients with chronic obstructive pulmonary disease （COPD）. Although there are still some doubts about the effect of LVRS, in the past 10 years, a lot of clinical information approved that LVRS can give benefit to more than 70% of COPD patients. At present, a series of researches in long-term investigation and function evaluation such as NETT have got elementary affirmative conclusion about some disputative problems.
文摘国际器官移植协会（The Transplantation Society，TIS）举办的第24届国际器官移植大会（24th International Congress of the Transplantation Society，24th ICTS）于2012年7月15-19日在德国柏林召开。来自英国达特茅斯Geisel医学院的RichardB．Freeman教授在大会发言中作了题为“实体器官移植长期效果”的专题演讲，依据国际上大范围、大样本的登记处资料以及相关的数据分析和研究，重点关注肾、肝、心脏移植等大器官移植10年或更长时间的疗效，对实体器官移植的现状、进展和存在的问题进行了总结。我们将Freeman教授报告的内容编译、整理为受者及移植物的长期存活情况、影响实体器官移植长期效果的因素、改善受者健康相关生活质量及移植物功能三部分内容，供国内移植同道们学习、交流。
