Objective:to study the effect of coixenolide (CXL) on irradiation of human nasophyaryngeal carcinoma cell line CNE-2Z in the absence of oxygen,Methods: Microcolony formation assay was used for determining the sensitiv...Objective:to study the effect of coixenolide (CXL) on irradiation of human nasophyaryngeal carcinoma cell line CNE-2Z in the absence of oxygen,Methods: Microcolony formation assay was used for determining the sensitivity of CNE-2Z to γ-ray in vitro,Results:When CNE-2Z was treated with 10^-7--10^-6 mol/L of CXL,CXL shifted the radiation dose-survival curve to the left,with the decrease of D0,Dq and N values,Radiation dose reduced 10.07%-35.69% at D37 level,the sensitizing enhancement ratios(SER) were 1.07-1.43 and 1.16-1.72 at D0 and Dq levels respectively.Conclusion:CXL increase susceptibility of CNE-2Z to ray under hypoxic condition by the mechanism of inhibiting its sublethal damgae repair.Subject words Nasopharyngeal neoplasm;Coixenolide;Radiosensitzation;Hypoxic irradiation.展开更多
基金This project was supported by Guangdong provincial natural science foundation (No.970839) and Guangdong provincial administrati
文摘Objective:to study the effect of coixenolide (CXL) on irradiation of human nasophyaryngeal carcinoma cell line CNE-2Z in the absence of oxygen,Methods: Microcolony formation assay was used for determining the sensitivity of CNE-2Z to γ-ray in vitro,Results:When CNE-2Z was treated with 10^-7--10^-6 mol/L of CXL,CXL shifted the radiation dose-survival curve to the left,with the decrease of D0,Dq and N values,Radiation dose reduced 10.07%-35.69% at D37 level,the sensitizing enhancement ratios(SER) were 1.07-1.43 and 1.16-1.72 at D0 and Dq levels respectively.Conclusion:CXL increase susceptibility of CNE-2Z to ray under hypoxic condition by the mechanism of inhibiting its sublethal damgae repair.Subject words Nasopharyngeal neoplasm;Coixenolide;Radiosensitzation;Hypoxic irradiation.
