High mobility group box-1(HMGB1)distributed widely.It exists in many organs.HMGB1 locates in nuclei and cytoplasm in normal condition.It involves in many activity of life(i.e.,duplication of DNA,cellular differentiati...High mobility group box-1(HMGB1)distributed widely.It exists in many organs.HMGB1 locates in nuclei and cytoplasm in normal condition.It involves in many activity of life(i.e.,duplication of DNA,cellular differentiation,gene expression).The immunocytes(i.e.,mononuclear macrophage and dendritic cells)secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines.It acts as proinflammatory cytokines,activates inflammatory and immunological responses.As a late mediators of inflammation and last long,HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.It has been initially proved in experimental and clinical study.展开更多
目的观察不同剂量他汀类药物治疗对动脉粥样硬化性脑梗死患者血浆S100B和高迁移率族蛋白B1(highmobility group protein B1,HMGB1)水平的影响。方法选择大动脉粥样硬化性脑梗死患者298例,根据服用阿托伐他汀钙剂量分为他汀高剂量(40mg/...目的观察不同剂量他汀类药物治疗对动脉粥样硬化性脑梗死患者血浆S100B和高迁移率族蛋白B1(highmobility group protein B1,HMGB1)水平的影响。方法选择大动脉粥样硬化性脑梗死患者298例,根据服用阿托伐他汀钙剂量分为他汀高剂量(40mg/晚)组106例,他汀标准剂量(20mg/晚)组134例,他汀空白组58例,另选择健康体检者67例作为对照组。记录各组入院时、7d血浆S100B、HMGB1水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果他汀高剂量组、他汀标准剂量组、他汀空白组入院时S100B水平较对照组明显升高[(38.19±30.10)pg/L,(38.41±23.75)pg/L,(32.47±25.04)pg/L vs(24.57±12.15)pg/L,P<0.05,P<0.01]。与他汀空白组比较,他汀高剂量组、他汀标准剂量组7d时S100B水平明显降低(P<0.05)。与他汀标准剂量组比较,他汀高剂量组7d时S100B水平明显降低(P<0.05)。与入院时比较,他汀空白组7d时S100B水平明显升高,他汀高剂量组7d时S100B水平明显降低(P<0.05,P<0.01)。入院时S100B水平与HDL-C(r=-0.224,P=0.010)、脑梗死体积(r=0.272,P=0.004)相关。结论阿托伐他汀钙不仅能调节血脂水平,还能降低炎性因子S100B水平,可能是其发挥抗炎及神经保护功能的机制之一。展开更多
High-mobility-group B1 (HMGB1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, and facilitates gene transcription. Recent studies...High-mobility-group B1 (HMGB1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, and facilitates gene transcription. Recent studies suggested that HMGB1 could be overexpressed and released from cellular nucleosome upon endotoxin and cytokine stimulation, or other stress challenge including burns, shock, as well as infection. Therefore, extracellular HMGB1 might be involved in the pathogenesis of sepsis and subsequent multiple organ dysfunction syndrome. Moreover, experimental data showed that extracellular HMGB1 might play vital roles in nerves development, tumor metastasis, atherosclerosis and restenosis after vascular damage.展开更多
文摘High mobility group box-1(HMGB1)distributed widely.It exists in many organs.HMGB1 locates in nuclei and cytoplasm in normal condition.It involves in many activity of life(i.e.,duplication of DNA,cellular differentiation,gene expression).The immunocytes(i.e.,mononuclear macrophage and dendritic cells)secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines.It acts as proinflammatory cytokines,activates inflammatory and immunological responses.As a late mediators of inflammation and last long,HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.It has been initially proved in experimental and clinical study.
文摘目的观察不同剂量他汀类药物治疗对动脉粥样硬化性脑梗死患者血浆S100B和高迁移率族蛋白B1(highmobility group protein B1,HMGB1)水平的影响。方法选择大动脉粥样硬化性脑梗死患者298例,根据服用阿托伐他汀钙剂量分为他汀高剂量(40mg/晚)组106例,他汀标准剂量(20mg/晚)组134例,他汀空白组58例,另选择健康体检者67例作为对照组。记录各组入院时、7d血浆S100B、HMGB1水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果他汀高剂量组、他汀标准剂量组、他汀空白组入院时S100B水平较对照组明显升高[(38.19±30.10)pg/L,(38.41±23.75)pg/L,(32.47±25.04)pg/L vs(24.57±12.15)pg/L,P<0.05,P<0.01]。与他汀空白组比较,他汀高剂量组、他汀标准剂量组7d时S100B水平明显降低(P<0.05)。与他汀标准剂量组比较,他汀高剂量组7d时S100B水平明显降低(P<0.05)。与入院时比较,他汀空白组7d时S100B水平明显升高,他汀高剂量组7d时S100B水平明显降低(P<0.05,P<0.01)。入院时S100B水平与HDL-C(r=-0.224,P=0.010)、脑梗死体积(r=0.272,P=0.004)相关。结论阿托伐他汀钙不仅能调节血脂水平,还能降低炎性因子S100B水平,可能是其发挥抗炎及神经保护功能的机制之一。
文摘High-mobility-group B1 (HMGB1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, and facilitates gene transcription. Recent studies suggested that HMGB1 could be overexpressed and released from cellular nucleosome upon endotoxin and cytokine stimulation, or other stress challenge including burns, shock, as well as infection. Therefore, extracellular HMGB1 might be involved in the pathogenesis of sepsis and subsequent multiple organ dysfunction syndrome. Moreover, experimental data showed that extracellular HMGB1 might play vital roles in nerves development, tumor metastasis, atherosclerosis and restenosis after vascular damage.
