： Objective To explore the mental dynamic change of the ten－ finger replanted patients,to give psychological rehabilitation guidance,and to improve the survival of the replantation and function recovery. Methods Tak...： Objective To explore the mental dynamic change of the ten－ finger replanted patients,to give psychological rehabilitation guidance,and to improve the survival of the replantation and function recovery. Methods Take psychological investigation with Scl－ 90 at different periods after operation,judge the exsisting negative psychological factors,and find the countermeasure of solution.Enable the patients to break away from the negative mentations in short period.Results Through the 1－ week,8－ week and 16－ week Scl－ 90 measurements after operation,we found that all the items’ score of the three times measurement was higher than the usual model(p<0.05),and fluctuated up and down with mental characteristics of different phases.The assessment of the replantation of the severed finger was good. Conclusion The psychological state of the patient would affect the survivial and function recovery of the replantation of severed finger directly.So the psychological rehabilitation nursing should be performed throughout the disease.展开更多
The repair of peripheral nerve injury after complete amputation is difficult,and even with anastomosis,the rapid recovery of nerve function remains challenging.Curcumin,extracted from plants of the genus Curcuma,has b...The repair of peripheral nerve injury after complete amputation is difficult,and even with anastomosis,the rapid recovery of nerve function remains challenging.Curcumin,extracted from plants of the genus Curcuma,has been shown to have anti-oxidant and anti-inflammatory properties and to improve sciatic nerve crush injury in rats.Here,we determined whether curcumin had neuroprotective effects following complete peripheral nerve amputation injury.BALB/c mice underwent complete sciatic nerve amputation,followed by an immediate epineurium anastomosis.Mice were intragastrically administered curcumin at doses of 40（high）,20（moderate）,and 10 mg/kg/d（low） for 1 week.We found that myelin in the mice of the high- and moderate-dose curcumin groups appeared with regular shape,uniform thickness,clear boundary,and little hyperplasia surrounding the myelin.High and moderate doses of curcumin markedly improved both action potential amplitude of the sciatic nerves and the conduction velocity of the corresponding motor neurons,and upregulated m RNA and protein expression of S100,a marker for Schwann cell proliferation,in L4–6 spinal cord segments.These results suggest that curcumin is effective in promoting the repair of complete sciatic nerve amputation injury and that the underlying mechanism may be associated with upregulation of S100 expression.展开更多
文摘： Objective To explore the mental dynamic change of the ten－ finger replanted patients,to give psychological rehabilitation guidance,and to improve the survival of the replantation and function recovery. Methods Take psychological investigation with Scl－ 90 at different periods after operation,judge the exsisting negative psychological factors,and find the countermeasure of solution.Enable the patients to break away from the negative mentations in short period.Results Through the 1－ week,8－ week and 16－ week Scl－ 90 measurements after operation,we found that all the items’ score of the three times measurement was higher than the usual model(p<0.05),and fluctuated up and down with mental characteristics of different phases.The assessment of the replantation of the severed finger was good. Conclusion The psychological state of the patient would affect the survivial and function recovery of the replantation of severed finger directly.So the psychological rehabilitation nursing should be performed throughout the disease.
基金supported by the Jilin Provincial Science & Technology Development Project Fund of China,No.20150311038YY
文摘The repair of peripheral nerve injury after complete amputation is difficult,and even with anastomosis,the rapid recovery of nerve function remains challenging.Curcumin,extracted from plants of the genus Curcuma,has been shown to have anti-oxidant and anti-inflammatory properties and to improve sciatic nerve crush injury in rats.Here,we determined whether curcumin had neuroprotective effects following complete peripheral nerve amputation injury.BALB/c mice underwent complete sciatic nerve amputation,followed by an immediate epineurium anastomosis.Mice were intragastrically administered curcumin at doses of 40（high）,20（moderate）,and 10 mg/kg/d（low） for 1 week.We found that myelin in the mice of the high- and moderate-dose curcumin groups appeared with regular shape,uniform thickness,clear boundary,and little hyperplasia surrounding the myelin.High and moderate doses of curcumin markedly improved both action potential amplitude of the sciatic nerves and the conduction velocity of the corresponding motor neurons,and upregulated m RNA and protein expression of S100,a marker for Schwann cell proliferation,in L4–6 spinal cord segments.These results suggest that curcumin is effective in promoting the repair of complete sciatic nerve amputation injury and that the underlying mechanism may be associated with upregulation of S100 expression.
