There is significant evidence to show that many neurosurgical patients with hyponatremia, who were previously diagnosed with syndrome of inappropriate antidiuretic hormone secretion(SIADH), actually have cerebral salt...There is significant evidence to show that many neurosurgical patients with hyponatremia, who were previously diagnosed with syndrome of inappropriate antidiuretic hormone secretion(SIADH), actually have cerebral salt wasting syndrome(CSWS). The critical difference between SIADH and CSWS is that CSWS involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition. The primary treatment for CSWS is water and salt replacement. The mechanisms underlying CSWS are not understood but may involve ANP or other natriuretic factors and direct neural influence on renal function.展开更多
目的探讨丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病（delayded encepha-lopathy after acute carbon monoxide poisoning,DEACMP）患者精神状态与认知功能的影响。方法选取100例DEACMP患者,按随机数字表法分为对照组和观察组各5...目的探讨丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病（delayded encepha-lopathy after acute carbon monoxide poisoning,DEACMP）患者精神状态与认知功能的影响。方法选取100例DEACMP患者,按随机数字表法分为对照组和观察组各50例。对照组采取常规治疗,观察组在常规治疗的基础上联合丁苯酞、依达拉奉治疗,2组均治疗3个疗程,疗程结束时评价疗效。治疗前和治疗1、2、3个疗程评定简易智能精神量表（mini-mental state examination,MMSE）,治疗前和疗程结束时评定美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale,NIHSS）、Barthel指数（Barthel index,BI）、长谷川痴呆量表（Hastgawa Dementia Scale,HDS）。结果观察组总有效率明显高于对照组（χ^2=5.741,P〈0.05）;治疗后2组MMSE评分均较治疗前明显升高,随着疗程的进展,MMSE评分不断增加,且观察组各时点MMSE评分高于对照组,组间、时点间、组间·时点间交互作用差异均有统计学意义（P〈0.05）。2组NIHSS评分较治疗前明显降低,BI、HDS评分均较治疗前明显升高（P〈0.05）;观察组NIHSS评分低于对照组,BI、HDS评分高于对照组（P〈0.05）。结论丁苯酞联合依达拉奉治疗DEACMP安全、有效,可明显改善患者的精神状态及认知功能障碍,提高患者的日常生活能力及智力水平,值得在临床上推广应用。展开更多
文摘There is significant evidence to show that many neurosurgical patients with hyponatremia, who were previously diagnosed with syndrome of inappropriate antidiuretic hormone secretion(SIADH), actually have cerebral salt wasting syndrome(CSWS). The critical difference between SIADH and CSWS is that CSWS involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition. The primary treatment for CSWS is water and salt replacement. The mechanisms underlying CSWS are not understood but may involve ANP or other natriuretic factors and direct neural influence on renal function.
文摘目的探讨丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病（delayded encepha-lopathy after acute carbon monoxide poisoning,DEACMP）患者精神状态与认知功能的影响。方法选取100例DEACMP患者,按随机数字表法分为对照组和观察组各50例。对照组采取常规治疗,观察组在常规治疗的基础上联合丁苯酞、依达拉奉治疗,2组均治疗3个疗程,疗程结束时评价疗效。治疗前和治疗1、2、3个疗程评定简易智能精神量表（mini-mental state examination,MMSE）,治疗前和疗程结束时评定美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale,NIHSS）、Barthel指数（Barthel index,BI）、长谷川痴呆量表（Hastgawa Dementia Scale,HDS）。结果观察组总有效率明显高于对照组（χ^2=5.741,P〈0.05）;治疗后2组MMSE评分均较治疗前明显升高,随着疗程的进展,MMSE评分不断增加,且观察组各时点MMSE评分高于对照组,组间、时点间、组间·时点间交互作用差异均有统计学意义（P〈0.05）。2组NIHSS评分较治疗前明显降低,BI、HDS评分均较治疗前明显升高（P〈0.05）;观察组NIHSS评分低于对照组,BI、HDS评分高于对照组（P〈0.05）。结论丁苯酞联合依达拉奉治疗DEACMP安全、有效,可明显改善患者的精神状态及认知功能障碍,提高患者的日常生活能力及智力水平,值得在临床上推广应用。
