目的比较在经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)中3种麻醉方法对患者闭孔神经反射和术后并发症的影响。方法回顾性分析我院2014年1月~2016年12月90例膀胱镜检查诊断为浅表性膀胱肿瘤接受TURBT的临床...目的比较在经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)中3种麻醉方法对患者闭孔神经反射和术后并发症的影响。方法回顾性分析我院2014年1月~2016年12月90例膀胱镜检查诊断为浅表性膀胱肿瘤接受TURBT的临床资料,依据麻醉方法分为3组:全身麻醉组(G组),脊椎-硬膜外麻醉组(C组),脊椎-硬膜外麻醉复合闭孔神经阻滞组(O组),每组30例。比较3组患者手术时间、出血量、闭孔神经反射发生率、膀胱损伤发生率、术后心血管和肺部并发症发生率、住院时间。结果3组患者膀胱损伤、手术时间、出血量、术后心血管并发症、术后肺部并发症差异均无统计学意义(P>0.05)。闭孔神经反射发生率C组为40.0%,显著高于G组3.3%(χ^2=11.882,P=0.001)和O组0.0%(P=0.000)。G组患者住院时间中位数7.0(6.0,8.0)d,明显长于C组6.0(5.0,6.0)d(Z=-2.798,P=0.015)和O组5.0(5.0,7.3)d(Z=-2.913,P=0.011)。结论全身麻醉和脊椎-硬膜外麻醉复合闭孔神经阻滞均可有效预防TURBT术中患者的闭孔神经反射。展开更多
A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection. Insulin-like growth factor 1 receptor (IGF-1R) signa...A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection. Insulin-like growth factor 1 receptor (IGF-1R) signaling plays a very important role in progression, invasion and metastasis of bladder cancer cells. In this study, we investigated whether IGF-1R was involved in the growth stimulating activity and drug resistance of bladder cancer cells. The results showed: The mRNAs of IGF-1, IGF-2 and IGF-1R were strongly expressed in serum-free cultured T24 cell line, whereas normal urothelial cells did not express these factors/receptors or only in trace levels; T24 cell responded far better to growth stimulation by IGF-1 than did normal urothelial cells; blockage of IGF1R by antisense oligodeoxynucleotide (ODN) significantly inhibited the growth of T24 cell and enhanced sensitivity and apoptosis of T24 cells to mitomycin (MMC). These results suggested that blockage of IGF-IR signaling might potentially contribute to the treatment of bladder cancer cells which are insensitive to chemotherapy.展开更多
文摘目的比较在经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)中3种麻醉方法对患者闭孔神经反射和术后并发症的影响。方法回顾性分析我院2014年1月~2016年12月90例膀胱镜检查诊断为浅表性膀胱肿瘤接受TURBT的临床资料,依据麻醉方法分为3组:全身麻醉组(G组),脊椎-硬膜外麻醉组(C组),脊椎-硬膜外麻醉复合闭孔神经阻滞组(O组),每组30例。比较3组患者手术时间、出血量、闭孔神经反射发生率、膀胱损伤发生率、术后心血管和肺部并发症发生率、住院时间。结果3组患者膀胱损伤、手术时间、出血量、术后心血管并发症、术后肺部并发症差异均无统计学意义(P>0.05)。闭孔神经反射发生率C组为40.0%,显著高于G组3.3%(χ^2=11.882,P=0.001)和O组0.0%(P=0.000)。G组患者住院时间中位数7.0(6.0,8.0)d,明显长于C组6.0(5.0,6.0)d(Z=-2.798,P=0.015)和O组5.0(5.0,7.3)d(Z=-2.913,P=0.011)。结论全身麻醉和脊椎-硬膜外麻醉复合闭孔神经阻滞均可有效预防TURBT术中患者的闭孔神经反射。
文摘A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection. Insulin-like growth factor 1 receptor (IGF-1R) signaling plays a very important role in progression, invasion and metastasis of bladder cancer cells. In this study, we investigated whether IGF-1R was involved in the growth stimulating activity and drug resistance of bladder cancer cells. The results showed: The mRNAs of IGF-1, IGF-2 and IGF-1R were strongly expressed in serum-free cultured T24 cell line, whereas normal urothelial cells did not express these factors/receptors or only in trace levels; T24 cell responded far better to growth stimulation by IGF-1 than did normal urothelial cells; blockage of IGF1R by antisense oligodeoxynucleotide (ODN) significantly inhibited the growth of T24 cell and enhanced sensitivity and apoptosis of T24 cells to mitomycin (MMC). These results suggested that blockage of IGF-IR signaling might potentially contribute to the treatment of bladder cancer cells which are insensitive to chemotherapy.
