AIM:To construct normal values for the tests of the psychometric hepatic encephalopathy score(PHES)and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy(MHE)among Chinese individuals with c...AIM:To construct normal values for the tests of the psychometric hepatic encephalopathy score(PHES)and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy(MHE)among Chinese individuals with cirrhosis.METHODS:The five tests of PHES,number connection test-A(NCT-A),number connection test-B,serial dotting test,line tracing test and digit symbol test(DST),were administered to all enrolled subjects in a quiet room with sufficient light.Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination.Based on the nomograms of healthy volunteers,the patients were classified as having MHE when their PHES was less than-4.RESULTS:In total,146 healthy volunteers completed all the PHES tests.Age and education years were confirmed to be predictors of all five tests.In total,53patients with liver cirrhosis completed the PHES.Of the patients with liver cirrhosis,24(45.3%),22(41.5%)and 7(13.2%)had Child-Pugh grades A,B and C,respectively.MHE was diagnosed in 26 patients(49.1%).Compared with compensated cirrhotic patients(Child A),decompensated cirrhotic patients(Child B and C)had a higher proportion of MHE(65.5%vs 29.2%).No differences in age and education years were found between the MHE and non-MHE groups.NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9%and a specificity of 96.3%(AUC=0.866,K=0.735).CONCLUSION:The proportion of MHE is associated with liver function.NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China.展开更多
In practice, retraining a trained classifier is necessary when novel data become available. This paper adopts an incremental learning procedure to adaptively train a Kernel-based Nonlinear Representor (KNR), a recentl...In practice, retraining a trained classifier is necessary when novel data become available. This paper adopts an incremental learning procedure to adaptively train a Kernel-based Nonlinear Representor (KNR), a recently presented nonlinear classifier for optimal pattern representation, so that its generalization ability may be evaluated in time-variant situation and a sparser representation is obtained for computationally intensive tasks. The addressed techniques are applied to handwritten digit classification to illustrate the feasibility for pattern recognition.展开更多
Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were colle...Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.展开更多
In interdigitated back contact(IBC)solar cells,the metal-electrode coverage on a p-type emitter is optimized by a PC2D simulation.The result shows that the variation of the metal coverage ratio(MCR)will affect both th...In interdigitated back contact(IBC)solar cells,the metal-electrode coverage on a p-type emitter is optimized by a PC2D simulation.The result shows that the variation of the metal coverage ratio(MCR)will affect both the surface passivation and the electrode-contact properties for the p-type emitter in IBC solar cells.We find that when R_(c) ranges from 0.08 to 0.16Ω·cm^(2),the MCR is optimized with a value of 25%and 33%,resulting in a highest energy-conversion efficiency.The dependences of both Voc and fill factor on MCR are simulated in order to explore the mechanism of the IBC solar cells.展开更多
Penicillium digitatum causes serious losses in postharvest citrus fruit.Exogenous salicylic acid(SA)can induce fruit resistance against various pathogens,but the mechanism remains unclear.Herein,a transcriptome-based ...Penicillium digitatum causes serious losses in postharvest citrus fruit.Exogenous salicylic acid(SA)can induce fruit resistance against various pathogens,but the mechanism remains unclear.Herein,a transcriptome-based approach was used to investigate the underlying mechanism of SA-induced citrus fruit resistance against P.digitatum.We found that CsWRKY70 and genes related to methyl salicylate(MeSA)biosynthesis(salicylate carboxymethyltransferase,SAMT)were induced by exogenous SA.Moreover,significant MeSA accumulation was detected in the SA-treated citrus fruit.The potential involvement of CsWRKY70 in regulating CsSAMT expression in citrus fruit was studied.Subcellular localization,dual luciferase,and electrophoretic mobility shift assays and an analysis of transient expression in fruit peel revealed that the nucleus‐localized transcriptional activator CsWRKY70 can activate the CsSAMT promoter by recognizing the W-box element.Taken together,the findings from this study offer new insights into the transcriptional regulatory mechanism of exogenous SA-induced disease resistance in Citrus sinensis fruit.展开更多
The self-affine measure associated with an expanding matrix and a finite digit set is uniquely determined by the self-affine identity with equal weight. The spectral and non-spectral problems on the self- affine measu...The self-affine measure associated with an expanding matrix and a finite digit set is uniquely determined by the self-affine identity with equal weight. The spectral and non-spectral problems on the self- affine measures have some surprising connections with a number of areas in mathematics, and have been received much attention in recent years. In the present paper, we shall determine the spectrality and non-spectrality of a class of self-aiffine measures with decomposable digit sets. We present a method to deal with such case, and clarify the spectrality and non-spectrality of a class of self-affine measures by applying this method.展开更多
文摘AIM:To construct normal values for the tests of the psychometric hepatic encephalopathy score(PHES)and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy(MHE)among Chinese individuals with cirrhosis.METHODS:The five tests of PHES,number connection test-A(NCT-A),number connection test-B,serial dotting test,line tracing test and digit symbol test(DST),were administered to all enrolled subjects in a quiet room with sufficient light.Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination.Based on the nomograms of healthy volunteers,the patients were classified as having MHE when their PHES was less than-4.RESULTS:In total,146 healthy volunteers completed all the PHES tests.Age and education years were confirmed to be predictors of all five tests.In total,53patients with liver cirrhosis completed the PHES.Of the patients with liver cirrhosis,24(45.3%),22(41.5%)and 7(13.2%)had Child-Pugh grades A,B and C,respectively.MHE was diagnosed in 26 patients(49.1%).Compared with compensated cirrhotic patients(Child A),decompensated cirrhotic patients(Child B and C)had a higher proportion of MHE(65.5%vs 29.2%).No differences in age and education years were found between the MHE and non-MHE groups.NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9%and a specificity of 96.3%(AUC=0.866,K=0.735).CONCLUSION:The proportion of MHE is associated with liver function.NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China.
基金Supported by the Key Project of Chinese Ministry of Education (No.105150).
文摘In practice, retraining a trained classifier is necessary when novel data become available. This paper adopts an incremental learning procedure to adaptively train a Kernel-based Nonlinear Representor (KNR), a recently presented nonlinear classifier for optimal pattern representation, so that its generalization ability may be evaluated in time-variant situation and a sparser representation is obtained for computationally intensive tasks. The addressed techniques are applied to handwritten digit classification to illustrate the feasibility for pattern recognition.
文摘Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.
文摘In interdigitated back contact(IBC)solar cells,the metal-electrode coverage on a p-type emitter is optimized by a PC2D simulation.The result shows that the variation of the metal coverage ratio(MCR)will affect both the surface passivation and the electrode-contact properties for the p-type emitter in IBC solar cells.We find that when R_(c) ranges from 0.08 to 0.16Ω·cm^(2),the MCR is optimized with a value of 25%and 33%,resulting in a highest energy-conversion efficiency.The dependences of both Voc and fill factor on MCR are simulated in order to explore the mechanism of the IBC solar cells.
基金supported by the National Natural Science Foundation of China(Grant numbers 31772027 and 31972126).
文摘Penicillium digitatum causes serious losses in postharvest citrus fruit.Exogenous salicylic acid(SA)can induce fruit resistance against various pathogens,but the mechanism remains unclear.Herein,a transcriptome-based approach was used to investigate the underlying mechanism of SA-induced citrus fruit resistance against P.digitatum.We found that CsWRKY70 and genes related to methyl salicylate(MeSA)biosynthesis(salicylate carboxymethyltransferase,SAMT)were induced by exogenous SA.Moreover,significant MeSA accumulation was detected in the SA-treated citrus fruit.The potential involvement of CsWRKY70 in regulating CsSAMT expression in citrus fruit was studied.Subcellular localization,dual luciferase,and electrophoretic mobility shift assays and an analysis of transient expression in fruit peel revealed that the nucleus‐localized transcriptional activator CsWRKY70 can activate the CsSAMT promoter by recognizing the W-box element.Taken together,the findings from this study offer new insights into the transcriptional regulatory mechanism of exogenous SA-induced disease resistance in Citrus sinensis fruit.
基金supported by National Natural Science Foundation of China (Grant Nos.10871123,11171201)
文摘The self-affine measure associated with an expanding matrix and a finite digit set is uniquely determined by the self-affine identity with equal weight. The spectral and non-spectral problems on the self- affine measures have some surprising connections with a number of areas in mathematics, and have been received much attention in recent years. In the present paper, we shall determine the spectrality and non-spectrality of a class of self-aiffine measures with decomposable digit sets. We present a method to deal with such case, and clarify the spectrality and non-spectrality of a class of self-affine measures by applying this method.
