Titanium alloys are widely used in aeronautics that demand a good combination of high strength, good corrosion resistance and low mass. The mechanical properties lead to challenges in machining operations such as high...Titanium alloys are widely used in aeronautics that demand a good combination of high strength, good corrosion resistance and low mass. The mechanical properties lead to challenges in machining operations such as high process temperature as well as rapidly increasing tool wear. The conventional tool materials are not able to maintain their hardness and other mechanical prop- erties at higher cutting temperatures encountered in high speed machining. In this work, the new material tools, which are poly- crystalline diamond （PCD） and polycrystalline cubic boron nitride （PCBN） tools, are used in high-speed milling of Ti-6.5AI-2Zr-IMo-IV （TA15） alloy. The performance and wear mechanism of the tools are investigated. Compared to PCBN tool, PCD tool has a much longer tool life, especially at higher cutting speeds. Analyses based on the SEM and EDX suggest that attrition, adhesion and diffusion are the main wear mechanisms of PCD and PCBN tools in high-speed milling of TA 15. Oxida- tion wear is also observed at PCBN tool/workpiece interface. Roughness, defects, micro-hardness and microstructure of the ma- chined surface are investigated. The recorded surface roughness values with PCD/PCBN tools are bellow 0.3 μm at initial and steady cutting stage. Micro-hardness analysis shows that the machined surface hardening depth with PCD and PCBN tools is small. There is no evidence of sub-surface defects with PCD and PCBN tools. It is concluded that for TA15 alloy, high-speed milling can be carried out with PCD/PCBN tools.展开更多
A systematic geometric model has been presented for calibration of a newly designed 5-axis turbine blade grinding machine. This machine is designed to serve a specific purpose to attain high accuracy and high efficien...A systematic geometric model has been presented for calibration of a newly designed 5-axis turbine blade grinding machine. This machine is designed to serve a specific purpose to attain high accuracy and high efficiency grinding of turbine blades by eliminating the hand grinding process. Although its topology is RPPPR （P： prismatic; R： rotary）, its design is quite distinct from the competitive machine tools. As error quantification is the only way to investigate, maintain and improve its accuracy, calibra- tion is recommended for its performance assessment and acceptance testing. Systematic geometric error modeling technique is implemented and 52 position dependent and position independent errors are identified while considering the machine as five rigid bodies by eliminating the set-up errors of workpiece and cutting tool. 39 of them are found to have influential errors and are accommodated for finding the resultant effect between the cutting tool and the workpiece in workspace volume. Rigid body kinematics techniques and homogenous transformation matrices are used for error synthesis.展开更多
The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptanc...The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research.展开更多
Hepatitis B virus(HBV)affects approximately two billion people worldwide and more than 240 million people in the world are currently chronic carrier that could develop serious complications in the future,like liver ci...Hepatitis B virus(HBV)affects approximately two billion people worldwide and more than 240 million people in the world are currently chronic carrier that could develop serious complications in the future,like liver cirrhosis and hepatocellular carcinoma.Although an extended HBV immunization program is being carried out since the early‘80s,representing effective preventive measure,leading to a dramatic reduction of HBV hepatitis incidence,globally HBV infection still represents a major public health problem.The HBV virus is a DNA virus belongs to the Hepadnaviridae family.The HBV-DNA is a circular,partial double strand genome.All coding information is on the minus DNA strand and it is organized into four open reading frames.Despite hepatitis B virus is a DNA virus,it has a high mutation rate due to its replicative strategy,that leads to the production of many nonidentical variants at each cycle of replication.In fact,it contains a polymerase without the proofreading activity,and uses an RNA intermediate(pg RNA)during its replication,so error frequencies are comparable to those seen in retroviruses and other RNA viruses rather than in more stable DNA viruses.Due to the low fidelity of the polymerase,the high replication rate and the overlapping reading frames,mutations occur throughout the genome and they have been identified both in the structural and not structural gene.The arise of mutations being to develop of a whole of viral variants called"quasi-species"and the prevalent population,which favors virus replication,was selected by viral fitness,host’s immune pressure and external pressure,i.e.,vaccination or antiviral therapy.Naturally occurring mutations were found both in acute and chronic subjects.In the present review we examine and discuss the most recent available data about HBV genetic variability and its significance.展开更多
基金National High-tech Research and Development Program of China (2009AA04Z116)Program for Changjiang Scholars and Innovative Research Team in University ( IRT0837)
文摘Titanium alloys are widely used in aeronautics that demand a good combination of high strength, good corrosion resistance and low mass. The mechanical properties lead to challenges in machining operations such as high process temperature as well as rapidly increasing tool wear. The conventional tool materials are not able to maintain their hardness and other mechanical prop- erties at higher cutting temperatures encountered in high speed machining. In this work, the new material tools, which are poly- crystalline diamond （PCD） and polycrystalline cubic boron nitride （PCBN） tools, are used in high-speed milling of Ti-6.5AI-2Zr-IMo-IV （TA15） alloy. The performance and wear mechanism of the tools are investigated. Compared to PCBN tool, PCD tool has a much longer tool life, especially at higher cutting speeds. Analyses based on the SEM and EDX suggest that attrition, adhesion and diffusion are the main wear mechanisms of PCD and PCBN tools in high-speed milling of TA 15. Oxida- tion wear is also observed at PCBN tool/workpiece interface. Roughness, defects, micro-hardness and microstructure of the ma- chined surface are investigated. The recorded surface roughness values with PCD/PCBN tools are bellow 0.3 μm at initial and steady cutting stage. Micro-hardness analysis shows that the machined surface hardening depth with PCD and PCBN tools is small. There is no evidence of sub-surface defects with PCD and PCBN tools. It is concluded that for TA15 alloy, high-speed milling can be carried out with PCD/PCBN tools.
文摘A systematic geometric model has been presented for calibration of a newly designed 5-axis turbine blade grinding machine. This machine is designed to serve a specific purpose to attain high accuracy and high efficiency grinding of turbine blades by eliminating the hand grinding process. Although its topology is RPPPR （P： prismatic; R： rotary）, its design is quite distinct from the competitive machine tools. As error quantification is the only way to investigate, maintain and improve its accuracy, calibra- tion is recommended for its performance assessment and acceptance testing. Systematic geometric error modeling technique is implemented and 52 position dependent and position independent errors are identified while considering the machine as five rigid bodies by eliminating the set-up errors of workpiece and cutting tool. 39 of them are found to have influential errors and are accommodated for finding the resultant effect between the cutting tool and the workpiece in workspace volume. Rigid body kinematics techniques and homogenous transformation matrices are used for error synthesis.
文摘The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research.
文摘Hepatitis B virus(HBV)affects approximately two billion people worldwide and more than 240 million people in the world are currently chronic carrier that could develop serious complications in the future,like liver cirrhosis and hepatocellular carcinoma.Although an extended HBV immunization program is being carried out since the early‘80s,representing effective preventive measure,leading to a dramatic reduction of HBV hepatitis incidence,globally HBV infection still represents a major public health problem.The HBV virus is a DNA virus belongs to the Hepadnaviridae family.The HBV-DNA is a circular,partial double strand genome.All coding information is on the minus DNA strand and it is organized into four open reading frames.Despite hepatitis B virus is a DNA virus,it has a high mutation rate due to its replicative strategy,that leads to the production of many nonidentical variants at each cycle of replication.In fact,it contains a polymerase without the proofreading activity,and uses an RNA intermediate(pg RNA)during its replication,so error frequencies are comparable to those seen in retroviruses and other RNA viruses rather than in more stable DNA viruses.Due to the low fidelity of the polymerase,the high replication rate and the overlapping reading frames,mutations occur throughout the genome and they have been identified both in the structural and not structural gene.The arise of mutations being to develop of a whole of viral variants called"quasi-species"and the prevalent population,which favors virus replication,was selected by viral fitness,host’s immune pressure and external pressure,i.e.,vaccination or antiviral therapy.Naturally occurring mutations were found both in acute and chronic subjects.In the present review we examine and discuss the most recent available data about HBV genetic variability and its significance.
