Background There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. Me...Background There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. Methods Totally, 18 female Ba-Ma mini-pigs were subjected to a 40% total body surface third-degree flame burn under anesthesia. Resuscitation therapy was applied 2 hours after the injury, using the burn shock fluid resuscitation formula commonly accepted in the surgical treatment of bums. The Ba-Ma mini-pigs were randomly assigned to three groups （six pigs in each group）： succinylated gelatin group （the artificial colloid used was succinylated gelatin Injection）, hydroxyethyl starch group （the artificial colloid used was hydroxyethyl starch （130/0.4））, and allogeneic plasma group （the colloid used was allogeneic plasma）. Blood samples were collected from the animals prior to the bum injury and again at intervals of 4, 8, 24 and 48 hours post-injury. The platelet count （PLT）, prothrombin time （PT）, international normalized ratio （INR）, activated partial thromboplastin time （APTT）, and fibrinogen （Fib） were measured, followed by a statistical analysis of all results. Results The PLT of succinylated gelatin group and hydroxyethyl starch group at intervals of 24 and 48 hours were （124.3±52.7）, （78.8±16.4）×10^9/L and （159.0±62.8）, （87.3±32.0）×10^9/L respectively. But in the allogeneic plasma group at intervals of 8, 24, and 48 hours were （234.3±52.6）, （136.0±47.4）, （75.8±31.0）×10^9/L. The decrease were all statistically significant （P 〈0.05, P 〈0.01） when compared to pre-burn （（383.3±77.9）, （382.7±65.7）, （381.0±49.4）×10^9/L）. The PLT among the three groups, at all the time points, had no statistical difference （P 〉0.05）. Compared to pre-burn （（10.8±0.9）, （11.4± 0.8）, （10.6±0.7） seconds）, the PT of succinylated gelatin group and hydroxyethyl starch group at 24 hours were （14.展开更多
文摘Background There are controversies about the use of artificial colloids. This research was aimed to determine the effect of various artificial colloids on blood coagulation in the shock stage of severe burn injury. Methods Totally, 18 female Ba-Ma mini-pigs were subjected to a 40% total body surface third-degree flame burn under anesthesia. Resuscitation therapy was applied 2 hours after the injury, using the burn shock fluid resuscitation formula commonly accepted in the surgical treatment of bums. The Ba-Ma mini-pigs were randomly assigned to three groups （six pigs in each group）： succinylated gelatin group （the artificial colloid used was succinylated gelatin Injection）, hydroxyethyl starch group （the artificial colloid used was hydroxyethyl starch （130/0.4））, and allogeneic plasma group （the colloid used was allogeneic plasma）. Blood samples were collected from the animals prior to the bum injury and again at intervals of 4, 8, 24 and 48 hours post-injury. The platelet count （PLT）, prothrombin time （PT）, international normalized ratio （INR）, activated partial thromboplastin time （APTT）, and fibrinogen （Fib） were measured, followed by a statistical analysis of all results. Results The PLT of succinylated gelatin group and hydroxyethyl starch group at intervals of 24 and 48 hours were （124.3±52.7）, （78.8±16.4）×10^9/L and （159.0±62.8）, （87.3±32.0）×10^9/L respectively. But in the allogeneic plasma group at intervals of 8, 24, and 48 hours were （234.3±52.6）, （136.0±47.4）, （75.8±31.0）×10^9/L. The decrease were all statistically significant （P 〈0.05, P 〈0.01） when compared to pre-burn （（383.3±77.9）, （382.7±65.7）, （381.0±49.4）×10^9/L）. The PLT among the three groups, at all the time points, had no statistical difference （P 〉0.05）. Compared to pre-burn （（10.8±0.9）, （11.4± 0.8）, （10.6±0.7） seconds）, the PT of succinylated gelatin group and hydroxyethyl starch group at 24 hours were （14.
