本文介绍了LTE Small Cell的基本概念,组网方式,主要应用和为LTE网络带来的收益,分析了Small Cell实际部署中所面临的主要问题和挑战,并针对性论述了解决问题所采用的关键技术和解决方案。重点描述了宏微干扰协同eICIC技术、时钟同步、...本文介绍了LTE Small Cell的基本概念,组网方式,主要应用和为LTE网络带来的收益,分析了Small Cell实际部署中所面临的主要问题和挑战,并针对性论述了解决问题所采用的关键技术和解决方案。重点描述了宏微干扰协同eICIC技术、时钟同步、回程网络、网络规划以及SON自组织网络等解决方案。展开更多
Rejoice Banda,étudianteà1 Universitédu Malawi,s’identifie désonnais comme une personne transformée dans le domaine numérique.Spécialisée enéquipement de réseaux Infor...Rejoice Banda,étudianteà1 Universitédu Malawi,s’identifie désonnais comme une personne transformée dans le domaine numérique.Spécialisée enéquipement de réseaux Informatiques,elle a récemment enrichi ses compétences dans les technologies de l in formation ei de la communication(TIC)grâceàune formation dispensée par le programme Seeds for the Future en novembre dernier.展开更多
1“There was a morning when our son asked for a glass of milk and I knew I didn't have any to give him,”says Erica Lacerda de Souza.The 32-year-old Brazilian and her husband,Bruce Lee Sousa,28,sold both of their ...1“There was a morning when our son asked for a glass of milk and I knew I didn't have any to give him,”says Erica Lacerda de Souza.The 32-year-old Brazilian and her husband,Bruce Lee Sousa,28,sold both of their cars,closed their wine shop and sent their son Henrique,then 6 years old,to live with his grandmother in the east end of São Paulo.With a few changes of clothes in a backpack and nowhere to go,the two ended up living at São Paulo's downtown Barra Funda Terminal.That was in July 2020.展开更多
The study explores the intricate interplay between land use land cover(LULC),normalized difference vegetation index(NDVI),and land surface temperature(LST)within the Lower Son River Basin in India from 1991 to 2020.Th...The study explores the intricate interplay between land use land cover(LULC),normalized difference vegetation index(NDVI),and land surface temperature(LST)within the Lower Son River Basin in India from 1991 to 2020.The region’s ecological balance has been increasingly strained due to rapid urbanization and changing land use patterns.Through a combination of Landsat TM&OLI/TIRS satellite imageries and geospatial analysis techniques,this study unveils the intricate connection between land use and land cover changes,vegetation,and land surface temperature variations.The study area is classified into three altitudinal zones(Zone Ⅰ:39–300 m,Zone Ⅱ:301–600 m and Zone Ⅲ:601–1,247 m)to examine the changes in depth.The area has seen significant changes in LULC,vegetation and LST in all the three altitudinal zones.The findings hold significant implications for sustainable land management and environmental conservation strategies in the Lower Son River Basin.As per the result,103,438 ha of vegetation was converted into agriculture land and 82,572 ha of agricultural land was transformed into settlements from 1991 to 2020.This trend shows human pressure on the land resource in the study area.Minor increase in water body is seen which is attributed to commissioning of Bansagar dam.Zone Ⅰ has seen highest settlement growth while Zone Ⅲ experienced severe deforestation of around 15%.Zone Ⅱ and Ⅲ needs attention for holistic sustenance.Analysis of LST shows that it has increased by 0.82℃ from 1991 to 2020 which is a red flag.The study underscores the critical importance of balanced land use practices to preserve ecological integrity and mitigate the adverse effects of urbanization and climate change.展开更多
The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that cov...The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS.However,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 months.One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of activity.Accordingly,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal degradation.Several of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not clear.The CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental animals.Resistance to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin ligase.Although highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.展开更多
文摘本文介绍了LTE Small Cell的基本概念,组网方式,主要应用和为LTE网络带来的收益,分析了Small Cell实际部署中所面临的主要问题和挑战,并针对性论述了解决问题所采用的关键技术和解决方案。重点描述了宏微干扰协同eICIC技术、时钟同步、回程网络、网络规划以及SON自组织网络等解决方案。
文摘Rejoice Banda,étudianteà1 Universitédu Malawi,s’identifie désonnais comme une personne transformée dans le domaine numérique.Spécialisée enéquipement de réseaux Informatiques,elle a récemment enrichi ses compétences dans les technologies de l in formation ei de la communication(TIC)grâceàune formation dispensée par le programme Seeds for the Future en novembre dernier.
文摘1“There was a morning when our son asked for a glass of milk and I knew I didn't have any to give him,”says Erica Lacerda de Souza.The 32-year-old Brazilian and her husband,Bruce Lee Sousa,28,sold both of their cars,closed their wine shop and sent their son Henrique,then 6 years old,to live with his grandmother in the east end of São Paulo.With a few changes of clothes in a backpack and nowhere to go,the two ended up living at São Paulo's downtown Barra Funda Terminal.That was in July 2020.
文摘The study explores the intricate interplay between land use land cover(LULC),normalized difference vegetation index(NDVI),and land surface temperature(LST)within the Lower Son River Basin in India from 1991 to 2020.The region’s ecological balance has been increasingly strained due to rapid urbanization and changing land use patterns.Through a combination of Landsat TM&OLI/TIRS satellite imageries and geospatial analysis techniques,this study unveils the intricate connection between land use and land cover changes,vegetation,and land surface temperature variations.The study area is classified into three altitudinal zones(Zone Ⅰ:39–300 m,Zone Ⅱ:301–600 m and Zone Ⅲ:601–1,247 m)to examine the changes in depth.The area has seen significant changes in LULC,vegetation and LST in all the three altitudinal zones.The findings hold significant implications for sustainable land management and environmental conservation strategies in the Lower Son River Basin.As per the result,103,438 ha of vegetation was converted into agriculture land and 82,572 ha of agricultural land was transformed into settlements from 1991 to 2020.This trend shows human pressure on the land resource in the study area.Minor increase in water body is seen which is attributed to commissioning of Bansagar dam.Zone Ⅰ has seen highest settlement growth while Zone Ⅲ experienced severe deforestation of around 15%.Zone Ⅱ and Ⅲ needs attention for holistic sustenance.Analysis of LST shows that it has increased by 0.82℃ from 1991 to 2020 which is a red flag.The study underscores the critical importance of balanced land use practices to preserve ecological integrity and mitigate the adverse effects of urbanization and climate change.
文摘The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS.However,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 months.One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of activity.Accordingly,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal degradation.Several of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not clear.The CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental animals.Resistance to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin ligase.Although highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.
