Non-alcoholic fatty liver disease(NAFLD)has a rising prevalence worldwide.It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption.Insulin resistance and oxidative damage plays...Non-alcoholic fatty liver disease(NAFLD)has a rising prevalence worldwide.It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption.Insulin resistance and oxidative damage plays a key role in its pathogenesis.[1]NAFLD is a complex disease,classified in simple steatosis(SS)and non-alcoholic steatohepatitis(NASH).Lifestyle changes and treatment of hyperinsulinaemia could reverse SS.However,20-30%of NAFLD patients develop to NASH,which could lead to liver fibrosis,cirrhosis and cancer.[2]展开更多
Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received...Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results： （1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.展开更多
Nonalcoholic fatty liver disease(NAFLD)is a systemic disor-der with a complex multifactorial pathogenesis and hetero-genous clinical manifestations.NAFLD,once believed to be an innocuous condition,has now become the m...Nonalcoholic fatty liver disease(NAFLD)is a systemic disor-der with a complex multifactorial pathogenesis and hetero-genous clinical manifestations.NAFLD,once believed to be an innocuous condition,has now become the most common cause of chronic liver disease in many countries worldwide.NAFLD is already highly prevalent in the general population,and owing to a rising incidence of obesity and diabetes mellitus,the incidence of NAFLD and its impact on global healthcare are expected to increase in the future.A subset of patients with NAFLD develops progressive liver disease lead-ing to cirrhosis,hepatocellular carcinoma,and liver failure.NAFLD has emerged as one of the leading causes of cirrhosis and hepatocellular carcinoma in recent years.Moreover,HCC can occur in NAFLD even in absence of cirrhosis.Compared with the general population,NAFLD increases the risk of liver-related,cardiovascular and all-cause mortality.NAFLD is bidirectionally associated with metabolic syndrome.NAFLD increases the risk and contributes to aggravation of the pathophysiology of atherosclerosis,cardiovascular diseases,diabetes mellitus,and chronic kidney disease.In addition,NAFLD is linked to colorectal polyps,polycystic ovarian syndrome,osteoporosis,obstructive sleep apnea,stroke,and various extrahepatic malignancies.Extended resection of steatotic liver is associated with increased risk of liver failure and mortality.There is an increasing trend of NAFLD-related cirrhosis requiring liver transplantation,and the recurrence of NAFLD in such patients is almost universal.This review discusses the growing burden of NAFLD,its outcomes,and adverse associations with various diseases.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)has a rising prevalence worldwide.It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption.Insulin resistance and oxidative damage plays a key role in its pathogenesis.[1]NAFLD is a complex disease,classified in simple steatosis(SS)and non-alcoholic steatohepatitis(NASH).Lifestyle changes and treatment of hyperinsulinaemia could reverse SS.However,20-30%of NAFLD patients develop to NASH,which could lead to liver fibrosis,cirrhosis and cancer.[2]
文摘Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results： （1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.
文摘Nonalcoholic fatty liver disease(NAFLD)is a systemic disor-der with a complex multifactorial pathogenesis and hetero-genous clinical manifestations.NAFLD,once believed to be an innocuous condition,has now become the most common cause of chronic liver disease in many countries worldwide.NAFLD is already highly prevalent in the general population,and owing to a rising incidence of obesity and diabetes mellitus,the incidence of NAFLD and its impact on global healthcare are expected to increase in the future.A subset of patients with NAFLD develops progressive liver disease lead-ing to cirrhosis,hepatocellular carcinoma,and liver failure.NAFLD has emerged as one of the leading causes of cirrhosis and hepatocellular carcinoma in recent years.Moreover,HCC can occur in NAFLD even in absence of cirrhosis.Compared with the general population,NAFLD increases the risk of liver-related,cardiovascular and all-cause mortality.NAFLD is bidirectionally associated with metabolic syndrome.NAFLD increases the risk and contributes to aggravation of the pathophysiology of atherosclerosis,cardiovascular diseases,diabetes mellitus,and chronic kidney disease.In addition,NAFLD is linked to colorectal polyps,polycystic ovarian syndrome,osteoporosis,obstructive sleep apnea,stroke,and various extrahepatic malignancies.Extended resection of steatotic liver is associated with increased risk of liver failure and mortality.There is an increasing trend of NAFLD-related cirrhosis requiring liver transplantation,and the recurrence of NAFLD in such patients is almost universal.This review discusses the growing burden of NAFLD,its outcomes,and adverse associations with various diseases.
