Liposarcomas (LS) are the second most common type of soft tissue malignancies in adults;they arise from mesenchymal cells and account for 1% of all adult cancers and 15% of all pediatric cancers. The site of origin ca...Liposarcomas (LS) are the second most common type of soft tissue malignancies in adults;they arise from mesenchymal cells and account for 1% of all adult cancers and 15% of all pediatric cancers. The site of origin can be from anywhere there is fat in the human body. LS are classified based on the primary site of origin, and mediastinal LS are extremely rare. When mediastinal neoplasms are stratified based on histology, they represent less than 1% of all </span><span style="font-family:Verdana;">mediastinal tumors. To date, less than 150 cases have been reported in the</span><span style="font-family:Verdana;"> English literature. This article aims to present an unusual case of an extremely rare malignancy and perform a systematic review of the latest literature. In </span><span style="font-family:Verdana;">this report, our group is documenting the presentation, management, and</span><span style="font-family:Verdana;"> outcome of a 65-year-old male patient with a massive anterior mediastinal primary LS. The tumor was displacing the mediastinum into the right chest, occupying most of the left chest, and pushing the diaphragm into the abdomen. Mediastinal liposarcomas are extremely rare malignancies and can prove to be challenging to diagnose and treat. Aggressive surgical treatment with R0 resection is the gold standard, however, tumor biology in many cases is associated with variable growth rates and encroachment of adjacent vital structures and blood vessels. When complex anatomical structures preclude an R0 resection, there is a high incidence of local recurrence. In cases where there is a high risk of recurrence, radiotherapy is indicated and chemotherapy has a more limited role.展开更多
The interaction between monosaccharides exhibits an important role in the assembly of monosaccharide-containing molecules. In this work, three common monosaccharides, glucose, galactose and mannose, are employed to in...The interaction between monosaccharides exhibits an important role in the assembly of monosaccharide-containing molecules. In this work, three common monosaccharides, glucose, galactose and mannose, are employed to investigate the effect of monosaccharide on the self-assembly of benzenetricarboxamide(BTA) core-containing molecules. In the presence of monosaccharides, three benzenetricarboxamide derivatives aggregate into different ordered structures. When alanine linkers are introduced to these molecules between the core and the monosacchride, morphologies of three types of monosaccharide BTAs turned to disordered, meanwhile their structures become similar with the increase of the length of alanine linkers, indicating the disappearance of the monosaccharide effects.展开更多
Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-...Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-spline interpolation algorithm is used,and a specially designed algorithm is proposed for classifying the disease grade according to the disc damage likelihood scale criterion,which is correlated strongly with the glaucoma process by quantity.This tool exhibits the best performance with a low overlapping error of 4.34%for the optic disk demarcation and 8.31%for the optic cup demarcation.It also has preferable time-consuming as compared to other tools and is a cross-platform system.This tool has already been utilized in building the ophthalmic image database in the cooperation of Center for Ophthalmic Imaging Research and The Second Xiangya Hospital.展开更多
文摘Liposarcomas (LS) are the second most common type of soft tissue malignancies in adults;they arise from mesenchymal cells and account for 1% of all adult cancers and 15% of all pediatric cancers. The site of origin can be from anywhere there is fat in the human body. LS are classified based on the primary site of origin, and mediastinal LS are extremely rare. When mediastinal neoplasms are stratified based on histology, they represent less than 1% of all </span><span style="font-family:Verdana;">mediastinal tumors. To date, less than 150 cases have been reported in the</span><span style="font-family:Verdana;"> English literature. This article aims to present an unusual case of an extremely rare malignancy and perform a systematic review of the latest literature. In </span><span style="font-family:Verdana;">this report, our group is documenting the presentation, management, and</span><span style="font-family:Verdana;"> outcome of a 65-year-old male patient with a massive anterior mediastinal primary LS. The tumor was displacing the mediastinum into the right chest, occupying most of the left chest, and pushing the diaphragm into the abdomen. Mediastinal liposarcomas are extremely rare malignancies and can prove to be challenging to diagnose and treat. Aggressive surgical treatment with R0 resection is the gold standard, however, tumor biology in many cases is associated with variable growth rates and encroachment of adjacent vital structures and blood vessels. When complex anatomical structures preclude an R0 resection, there is a high incidence of local recurrence. In cases where there is a high risk of recurrence, radiotherapy is indicated and chemotherapy has a more limited role.
基金The Ministry of Science and Technology of China and the National Natural Science Foundation of China(Nos.91527305 and 51322306)are acknowledged for their financial support
文摘The interaction between monosaccharides exhibits an important role in the assembly of monosaccharide-containing molecules. In this work, three common monosaccharides, glucose, galactose and mannose, are employed to investigate the effect of monosaccharide on the self-assembly of benzenetricarboxamide(BTA) core-containing molecules. In the presence of monosaccharides, three benzenetricarboxamide derivatives aggregate into different ordered structures. When alanine linkers are introduced to these molecules between the core and the monosacchride, morphologies of three types of monosaccharide BTAs turned to disordered, meanwhile their structures become similar with the increase of the length of alanine linkers, indicating the disappearance of the monosaccharide effects.
基金Projects(61672542,61573380)supported by the National Natural Science Foundation of ChinaProject(2016zzts055)supported by Fundamental Research Funds for the Central Universities,China
文摘Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-spline interpolation algorithm is used,and a specially designed algorithm is proposed for classifying the disease grade according to the disc damage likelihood scale criterion,which is correlated strongly with the glaucoma process by quantity.This tool exhibits the best performance with a low overlapping error of 4.34%for the optic disk demarcation and 8.31%for the optic cup demarcation.It also has preferable time-consuming as compared to other tools and is a cross-platform system.This tool has already been utilized in building the ophthalmic image database in the cooperation of Center for Ophthalmic Imaging Research and The Second Xiangya Hospital.
