A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by ^1H NMR, ^13C ...A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by ^1H NMR, ^13C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes （EGFR） in vitro was 44.4% at the concentration of 5.5 μmol/L.展开更多
基金the financial support of Key International S&T Cooperation Projects(No.2008DFA31040 and No.2009DFA32080) of Ministry of Science and Technology of the People's Republic of China
文摘A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by ^1H NMR, ^13C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes （EGFR） in vitro was 44.4% at the concentration of 5.5 μmol/L.
