H 1,2,4 Benzothiadiazine 1,1 dioxide derivatives have been widely used in pharmaceutical chemistry.The formation of thiazide ring is a key step for preparing these compounds.Here we described a novel synthesis of the ...H 1,2,4 Benzothiadiazine 1,1 dioxide derivatives have been widely used in pharmaceutical chemistry.The formation of thiazide ring is a key step for preparing these compounds.Here we described a novel synthesis of the titled compounds in which the thiazide ring is formed conveniently by employing phosphorus oxychloride as dehydrating agent.The structures of the products were characterized by means of elemental analysis, 1HNMR,IR and ultraviolet spectra etc.The total yields of the titled compounds are above 45 percent.展开更多
A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been devel- oped. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino...A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been devel- oped. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino- 1,3,4-oxadiazoles are efficiently obtained in good yields.展开更多
A convenient route for the synthesis of 3,4-dihydrocoumarin derivates from salicylaldehyde derivates and 1,3-dicarbonyl compounds under solvent-free microwave irradiation conditions was described. In this way, a range...A convenient route for the synthesis of 3,4-dihydrocoumarin derivates from salicylaldehyde derivates and 1,3-dicarbonyl compounds under solvent-free microwave irradiation conditions was described. In this way, a range of compounds was obtained in moderate to good yields in a short reaction time.展开更多
文摘H 1,2,4 Benzothiadiazine 1,1 dioxide derivatives have been widely used in pharmaceutical chemistry.The formation of thiazide ring is a key step for preparing these compounds.Here we described a novel synthesis of the titled compounds in which the thiazide ring is formed conveniently by employing phosphorus oxychloride as dehydrating agent.The structures of the products were characterized by means of elemental analysis, 1HNMR,IR and ultraviolet spectra etc.The total yields of the titled compounds are above 45 percent.
文摘A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been devel- oped. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino- 1,3,4-oxadiazoles are efficiently obtained in good yields.
基金the National Natural Science Foundation of China(No.20702023)Special Fund for DoctoralProgram from the Ministry of Education of China(No.20070730040)for financial support.
文摘A convenient route for the synthesis of 3,4-dihydrocoumarin derivates from salicylaldehyde derivates and 1,3-dicarbonyl compounds under solvent-free microwave irradiation conditions was described. In this way, a range of compounds was obtained in moderate to good yields in a short reaction time.
