To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families thr...To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families through the population -based Salisbury Eye Evaluation study. Subjects underwent noncycloplegic refrac tion if best-corrected visual acuity (BCVA) was ≤20/40, had lensometry to meas ure their currently worn spectacles if BCVA was > 20/40 with spectacles, or were considered to be plano (refraction of zero) if the BCVA was > 20/40 without spe ctacles. Preoperative refraction from medical records was used for bilaterally p seudophakic subjects. Utilizing hyperopia cutoffs from 1.00 to 2.50 diopters, ag e-, race-, and gender-ad-justed odds ratios for hyperopia with an affected s ibling ranged from 2.72 (95%confidence interval [CI], 1.84-4.01) to 4.87 (95 % CI, 2.54-9.30). The odds of hyperopia increased with age until 75 years, after which they remained relatively constant. Black men were significantly less likel y to be hyperopic than white men, white women, or black women. Hyperopia appears to be under strong genetic control in this older population.展开更多
文摘To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families through the population -based Salisbury Eye Evaluation study. Subjects underwent noncycloplegic refrac tion if best-corrected visual acuity (BCVA) was ≤20/40, had lensometry to meas ure their currently worn spectacles if BCVA was > 20/40 with spectacles, or were considered to be plano (refraction of zero) if the BCVA was > 20/40 without spe ctacles. Preoperative refraction from medical records was used for bilaterally p seudophakic subjects. Utilizing hyperopia cutoffs from 1.00 to 2.50 diopters, ag e-, race-, and gender-ad-justed odds ratios for hyperopia with an affected s ibling ranged from 2.72 (95%confidence interval [CI], 1.84-4.01) to 4.87 (95 % CI, 2.54-9.30). The odds of hyperopia increased with age until 75 years, after which they remained relatively constant. Black men were significantly less likel y to be hyperopic than white men, white women, or black women. Hyperopia appears to be under strong genetic control in this older population.
