To the Editor:Obstructive sleep apnea syndrome(OSAS)is characterized by repetitive episodes of upper airway obstruction(partial or complete)during sleep,which leads to recurrent arterial hypoxemia and sleep fragmentat...To the Editor:Obstructive sleep apnea syndrome(OSAS)is characterized by repetitive episodes of upper airway obstruction(partial or complete)during sleep,which leads to recurrent arterial hypoxemia and sleep fragmentation.Untreated OSAS in middle-aged patients cause impair-ments in attention,vigilance,some aspects of memory,and executive function.[1]Transient ischemic attack(TIA)is characterized by a transient episode of neurological dysfunction caused by focal brain ischemia.By definition,TIA should not bring persistent deficits but it does increase the risk of long-term cognitive impairment.展开更多
Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihyperte...Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihypertension medications can also decrease arterial stiffness or control the blood pressure increasing following obstructive events is not well described This study aimed to investigate whether antihypertensive medications can ameliorate the changes in arterial stiffness and blood pressure associated with OSA Methods Sixtyone OSAS patients [13 women, 48 men, mean age (534±123) years], 26 normotensive patients (N), 7 hypertensive patients on no antihypertension medications (H), and 28 hypertensive patients on various combination antihypertension therapy (HM), were prospectively diagnosed with standard nocturnal polysomnography Beattobeat blood pressure was continuously recorded from the radial artery by applanation tonometry during baseline sleep As a measure of arterial stiffness, arterial augmentation index (AAI) was calculated as the ratio of augmented systolic blood pressure (SBP) to pulse pressure and expressed as a percentage for the following conditions: awakening, the first 10 ('early apnea') and last 10 ('late apnea') cardiac cycles of obstructive events (apnea or hypopnea), and the first 15 cardiac cycles following event termination ('post apnea') for all events with nadir O2 saturation ≤89% Results Systolic blood pressure (SBP) postapnea [(14274±1306) mmHg (N), (13706±2656) mmHg (H), (13694±141) mmHg (HM)] was significantly increased from awakening [(13576±1476) mmHg (N), (13558±2317) mmHg (H), (12977±1400) mmHg (HM)], early apnea [(13053±1265) mmHg (N), (12447±2497) mmHg (H), (12604±1312) mmHg (HM)], and late apnea [(1298±1268) mmHg(N), (12478±2515) mmHg (H), (12448±1382) mmHg (HM)] respectively (P<0001, repeated measures ANOVA) AAI was significantly increased for the N group (P<0001) from awakening to late apnea [(1045±262)% vs (1443±321)%] and from early apnea to late apnea 展开更多
基金supported by the Shandong Provincial Natural Science Foundation of China(No.ZR2016HB37).
文摘To the Editor:Obstructive sleep apnea syndrome(OSAS)is characterized by repetitive episodes of upper airway obstruction(partial or complete)during sleep,which leads to recurrent arterial hypoxemia and sleep fragmentation.Untreated OSAS in middle-aged patients cause impair-ments in attention,vigilance,some aspects of memory,and executive function.[1]Transient ischemic attack(TIA)is characterized by a transient episode of neurological dysfunction caused by focal brain ischemia.By definition,TIA should not bring persistent deficits but it does increase the risk of long-term cognitive impairment.
文摘Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihypertension medications can also decrease arterial stiffness or control the blood pressure increasing following obstructive events is not well described This study aimed to investigate whether antihypertensive medications can ameliorate the changes in arterial stiffness and blood pressure associated with OSA Methods Sixtyone OSAS patients [13 women, 48 men, mean age (534±123) years], 26 normotensive patients (N), 7 hypertensive patients on no antihypertension medications (H), and 28 hypertensive patients on various combination antihypertension therapy (HM), were prospectively diagnosed with standard nocturnal polysomnography Beattobeat blood pressure was continuously recorded from the radial artery by applanation tonometry during baseline sleep As a measure of arterial stiffness, arterial augmentation index (AAI) was calculated as the ratio of augmented systolic blood pressure (SBP) to pulse pressure and expressed as a percentage for the following conditions: awakening, the first 10 ('early apnea') and last 10 ('late apnea') cardiac cycles of obstructive events (apnea or hypopnea), and the first 15 cardiac cycles following event termination ('post apnea') for all events with nadir O2 saturation ≤89% Results Systolic blood pressure (SBP) postapnea [(14274±1306) mmHg (N), (13706±2656) mmHg (H), (13694±141) mmHg (HM)] was significantly increased from awakening [(13576±1476) mmHg (N), (13558±2317) mmHg (H), (12977±1400) mmHg (HM)], early apnea [(13053±1265) mmHg (N), (12447±2497) mmHg (H), (12604±1312) mmHg (HM)], and late apnea [(1298±1268) mmHg(N), (12478±2515) mmHg (H), (12448±1382) mmHg (HM)] respectively (P<0001, repeated measures ANOVA) AAI was significantly increased for the N group (P<0001) from awakening to late apnea [(1045±262)% vs (1443±321)%] and from early apnea to late apnea
