目的研究脑脊液置换加静滴及鞘内注射两性毒素 B 治疗新型隐球菌性脑膜炎(简称隐脑)的疗效。方法将收治的28例隐脑患者随机分为两组。A 组脑脊液置换加静滴及鞘内注射两性霉素 B 为治疗组。B 组仅静滴及鞘内注射两性霉素 B 为对照组,治...目的研究脑脊液置换加静滴及鞘内注射两性毒素 B 治疗新型隐球菌性脑膜炎(简称隐脑)的疗效。方法将收治的28例隐脑患者随机分为两组。A 组脑脊液置换加静滴及鞘内注射两性霉素 B 为治疗组。B 组仅静滴及鞘内注射两性霉素 B 为对照组,治疗共16周。以症状、体征、CSF 常规、CSF 培养及涂片为评定疗效。结果治疗组比对照组疗效佳,两者比较差异有统计学意义(P<0.05)。结论治疗组疗效佳,在基层医院不失为一种治疗新型隐球菌性脑膜炎的最佳方法之一,值得进一步研究。而两性霉素 B 仍为治疗隐脑最基本,最廉价和最重要的药物之一。展开更多
A 34-year-old female with stiff-person syndrome(SPS)is reported in this paper.She experienced short-term memory impairment and was diagnosed with anti-glutamic add decarboxylase(GAD)autoimmune encephalitis(AE)at the l...A 34-year-old female with stiff-person syndrome(SPS)is reported in this paper.She experienced short-term memory impairment and was diagnosed with anti-glutamic add decarboxylase(GAD)autoimmune encephalitis(AE)at the local hospital.However,after the treatment with intravenous immunoglobulin and highdose glucocorticoids,her symptoms unchanged.Two months later,she was admitted to our hospital due to an unstable gait and persistent leg stiffness,at which point she was diagnosed as anti-GAD AE concomitant with SPS.Her clinical symptoms improved with an increased dose of y-aminobutyric acid(GABA)-enhancing drug and plasma exchange.Anti-GAD antibody-associated AE combined with SPS is extremely rare.Treatment with GABA-enhancing drugs and appropriate immunotherapy can improve the neurological function of patients suffering from the combination of SPS and limbic encephalitis.展开更多
文摘目的研究脑脊液置换加静滴及鞘内注射两性毒素 B 治疗新型隐球菌性脑膜炎(简称隐脑)的疗效。方法将收治的28例隐脑患者随机分为两组。A 组脑脊液置换加静滴及鞘内注射两性霉素 B 为治疗组。B 组仅静滴及鞘内注射两性霉素 B 为对照组,治疗共16周。以症状、体征、CSF 常规、CSF 培养及涂片为评定疗效。结果治疗组比对照组疗效佳,两者比较差异有统计学意义(P<0.05)。结论治疗组疗效佳,在基层医院不失为一种治疗新型隐球菌性脑膜炎的最佳方法之一,值得进一步研究。而两性霉素 B 仍为治疗隐脑最基本,最廉价和最重要的药物之一。
文摘A 34-year-old female with stiff-person syndrome(SPS)is reported in this paper.She experienced short-term memory impairment and was diagnosed with anti-glutamic add decarboxylase(GAD)autoimmune encephalitis(AE)at the local hospital.However,after the treatment with intravenous immunoglobulin and highdose glucocorticoids,her symptoms unchanged.Two months later,she was admitted to our hospital due to an unstable gait and persistent leg stiffness,at which point she was diagnosed as anti-GAD AE concomitant with SPS.Her clinical symptoms improved with an increased dose of y-aminobutyric acid(GABA)-enhancing drug and plasma exchange.Anti-GAD antibody-associated AE combined with SPS is extremely rare.Treatment with GABA-enhancing drugs and appropriate immunotherapy can improve the neurological function of patients suffering from the combination of SPS and limbic encephalitis.
