在抗肿瘤免疫中，肿瘤特异性 T 细胞应答，特别是CD8＋T 细胞（cytotoxic T cell，CTL）对肿瘤细胞的杀伤是至关重要的免疫保护机制，肿瘤特异性CD4＋T 细胞分泌的 IFN-γ（interferon-γ，IFN-γ）以及肿瘤抗原特异性 IgG （immunoglob...在抗肿瘤免疫中，肿瘤特异性 T 细胞应答，特别是CD8＋T 细胞（cytotoxic T cell，CTL）对肿瘤细胞的杀伤是至关重要的免疫保护机制，肿瘤特异性CD4＋T 细胞分泌的 IFN-γ（interferon-γ，IFN-γ）以及肿瘤抗原特异性 IgG （immunoglobulin G， IgG）抗体也具有重要的清除肿瘤的功能。常见的恶性肿瘤如宫颈癌、鼻咽癌等恶性肿瘤均存在免疫细胞数量和功能的改变，关于改善细胞免疫功能可能提高抗肿瘤效果的研究已成为热点。肿瘤的发生、发展与 T 细胞组成和数量的变化密切相关，T细胞功能与人类白细胞抗原、表皮生长因子、协同刺激分子、细胞因子等均存在联系。本文对 T细胞免疫与恶性肿瘤之间的关系简要综述如下。展开更多
Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17...Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.展开更多
文摘在抗肿瘤免疫中，肿瘤特异性 T 细胞应答，特别是CD8＋T 细胞（cytotoxic T cell，CTL）对肿瘤细胞的杀伤是至关重要的免疫保护机制，肿瘤特异性CD4＋T 细胞分泌的 IFN-γ（interferon-γ，IFN-γ）以及肿瘤抗原特异性 IgG （immunoglobulin G， IgG）抗体也具有重要的清除肿瘤的功能。常见的恶性肿瘤如宫颈癌、鼻咽癌等恶性肿瘤均存在免疫细胞数量和功能的改变，关于改善细胞免疫功能可能提高抗肿瘤效果的研究已成为热点。肿瘤的发生、发展与 T 细胞组成和数量的变化密切相关，T细胞功能与人类白细胞抗原、表皮生长因子、协同刺激分子、细胞因子等均存在联系。本文对 T细胞免疫与恶性肿瘤之间的关系简要综述如下。
文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.
