目的基于CiteSpace对2012-2021年血液透析相关感染文献进行可视化图谱分析,分析其研究现状、热点及变化趋势。方法以hemodialysis、infection为主题,检索Web of Science核心数据库相关文献,检索时间设置为2012年1月1日-2021年12月30日...目的基于CiteSpace对2012-2021年血液透析相关感染文献进行可视化图谱分析,分析其研究现状、热点及变化趋势。方法以hemodialysis、infection为主题,检索Web of Science核心数据库相关文献,检索时间设置为2012年1月1日-2021年12月30日。应用CiteSpace 5.8.R3软件对作者、机构、国家、关键词、分类等进行可视化分析。结果共纳入3716篇相关文献。从发文趋势可知,血液透析相关感染一直为研究重点,近10年年发文量总体呈增长趋势,且年发文量维持在300篇以上。从国家与机构可知,排名前3的国家分别是美国、中国、日本,且美国中介中心性最高,而研究机构中以多伦多大学发文量最多。Fabrizio Fabrizi是发文量最多的作者,其主要研究方向为血液透析患者丙型病毒性肝炎感染。对关键词进行可视化分析,血液透析、感染、终末期肾病、死亡率、危险因素、预防、血管通路为高频关键词。关键词突现中肝炎、抗病毒治疗可能为未来研究重点。科目分类中社会科学、机械工程中心性较高。结论血液透析相关感染近几年发文量升高,丙型病毒性肝炎感染一直为研究热点,抗病毒治疗的研究未来仍具有发展前景。展开更多
Depression is a recurring and potentially lifethreatening disorderthat is major cause of morbidity and mor-tality. Stressful eventscan precipitate factors in the onset of major depressionand stress paradigms have long...Depression is a recurring and potentially lifethreatening disorderthat is major cause of morbidity and mor-tality. Stressful eventscan precipitate factors in the onset of major depressionand stress paradigms have long been used to modeldepressive status. The stress hormone glucocorticoid generates superoxide via increase in NADPH oxi- dase, which results inover-stimulation of phosphodiesterase 2 （PDE2） activity during stress. The present study in- vestigated whether PDE2 overexpression led to dysfunction of cyclic adenosine monophosphate （cAMP）/and cyclic guanosine monophosphate （cGMP） signaling that rapidly affects emotional function. The results suggested thatinhi- bition of PDE2by Bay 60 - 7550 and lenti-PDE2-miRNA reversedstress-induced depression-like behaviors. Consid- ering that memory improvement is the critical determinant of functional outcome in treatment of major depression, the cognitive performance was also studied. PDE2 inhibition was shown to improve the cognition in the Morris water maze and novel object recognition tests. Pretreatment with the oxidizing agent DTNB prevented, while the reducing agent DTT and NADPH oxidase inhibitor apocynin potentiated, the effects of Bay 60 - 7550 on behaviors in depres- sion and cognition, indicating the role of PDE2 in the oxidative stress-induced depression associated cognitive defi- cits. Consistently, the increases in dendritic branching and length of hippocampal neurons after inhibition of PDE2 were suppressed by DTNB; whereas the potentiation was observed by treatment with DTT or apocynin. The subse- quent in vitrostudy suggested that oxidative stress-induced ROS expression was positively related to PDE2 levels, which was consistent with the in vivo data. PDE2 inhibitor Bay 60 - 7550 and silencing PDE2 by lenti-PDE2-miR- NA decreased stress hormone corticosterone-induced increases in NADPH oxidase subunits, such as gp91 phox, in the hippocampal cells. The fact that gp91 phox knockdown potentiated the effect of PDE2 inhibition on depression and展开更多
目的 调查江苏省昆山市第一人民医院维持性血液透析（maintenance hemodialysis,MHD）患者的慢性肾脏病矿物质及骨代谢异常（chronic kidney disease-mineral and bone disorders,CKD-MBD）情况,比较分析老年和非老年患者CKD-MBD的特点...目的 调查江苏省昆山市第一人民医院维持性血液透析（maintenance hemodialysis,MHD）患者的慢性肾脏病矿物质及骨代谢异常（chronic kidney disease-mineral and bone disorders,CKD-MBD）情况,比较分析老年和非老年患者CKD-MBD的特点,为临床治疗提供依据.方法 调查234例MHD患者的透析龄、透前肌酐、血小板、白蛋白、血色素、血钙、血磷、ALP及iPTH的水平及临床资料,与指南比较分析老年组和非老年组血钙、血磷、ALP及iPTH的特点.结果 我院MHD患者非老年组患病率高于老年组（P＜0.05）;透析龄、干体重、透前肌酐、白蛋白水平等指标两组间差异无统计学意义（P＞0.05）;血清钙、磷、iPTH达标率分别为83.76％、19.66％、40.17％.两组比较,老年组血清钙、磷、iPTH、ALP均不同程度的低于非老年组,差异有统计学意义（P＜0.05）.结论 老年组MHD患者CKD-MBD指标低于非老年组,提示两组患者CKD-MBD发生机制存在差异,老年患者容易合并低转运骨病（akinesis bone disease,ABD）.展开更多
文摘目的基于CiteSpace对2012-2021年血液透析相关感染文献进行可视化图谱分析,分析其研究现状、热点及变化趋势。方法以hemodialysis、infection为主题,检索Web of Science核心数据库相关文献,检索时间设置为2012年1月1日-2021年12月30日。应用CiteSpace 5.8.R3软件对作者、机构、国家、关键词、分类等进行可视化分析。结果共纳入3716篇相关文献。从发文趋势可知,血液透析相关感染一直为研究重点,近10年年发文量总体呈增长趋势,且年发文量维持在300篇以上。从国家与机构可知,排名前3的国家分别是美国、中国、日本,且美国中介中心性最高,而研究机构中以多伦多大学发文量最多。Fabrizio Fabrizi是发文量最多的作者,其主要研究方向为血液透析患者丙型病毒性肝炎感染。对关键词进行可视化分析,血液透析、感染、终末期肾病、死亡率、危险因素、预防、血管通路为高频关键词。关键词突现中肝炎、抗病毒治疗可能为未来研究重点。科目分类中社会科学、机械工程中心性较高。结论血液透析相关感染近几年发文量升高,丙型病毒性肝炎感染一直为研究热点,抗病毒治疗的研究未来仍具有发展前景。
文摘Depression is a recurring and potentially lifethreatening disorderthat is major cause of morbidity and mor-tality. Stressful eventscan precipitate factors in the onset of major depressionand stress paradigms have long been used to modeldepressive status. The stress hormone glucocorticoid generates superoxide via increase in NADPH oxi- dase, which results inover-stimulation of phosphodiesterase 2 （PDE2） activity during stress. The present study in- vestigated whether PDE2 overexpression led to dysfunction of cyclic adenosine monophosphate （cAMP）/and cyclic guanosine monophosphate （cGMP） signaling that rapidly affects emotional function. The results suggested thatinhi- bition of PDE2by Bay 60 - 7550 and lenti-PDE2-miRNA reversedstress-induced depression-like behaviors. Consid- ering that memory improvement is the critical determinant of functional outcome in treatment of major depression, the cognitive performance was also studied. PDE2 inhibition was shown to improve the cognition in the Morris water maze and novel object recognition tests. Pretreatment with the oxidizing agent DTNB prevented, while the reducing agent DTT and NADPH oxidase inhibitor apocynin potentiated, the effects of Bay 60 - 7550 on behaviors in depres- sion and cognition, indicating the role of PDE2 in the oxidative stress-induced depression associated cognitive defi- cits. Consistently, the increases in dendritic branching and length of hippocampal neurons after inhibition of PDE2 were suppressed by DTNB; whereas the potentiation was observed by treatment with DTT or apocynin. The subse- quent in vitrostudy suggested that oxidative stress-induced ROS expression was positively related to PDE2 levels, which was consistent with the in vivo data. PDE2 inhibitor Bay 60 - 7550 and silencing PDE2 by lenti-PDE2-miR- NA decreased stress hormone corticosterone-induced increases in NADPH oxidase subunits, such as gp91 phox, in the hippocampal cells. The fact that gp91 phox knockdown potentiated the effect of PDE2 inhibition on depression and
文摘目的 调查江苏省昆山市第一人民医院维持性血液透析（maintenance hemodialysis,MHD）患者的慢性肾脏病矿物质及骨代谢异常（chronic kidney disease-mineral and bone disorders,CKD-MBD）情况,比较分析老年和非老年患者CKD-MBD的特点,为临床治疗提供依据.方法 调查234例MHD患者的透析龄、透前肌酐、血小板、白蛋白、血色素、血钙、血磷、ALP及iPTH的水平及临床资料,与指南比较分析老年组和非老年组血钙、血磷、ALP及iPTH的特点.结果 我院MHD患者非老年组患病率高于老年组（P＜0.05）;透析龄、干体重、透前肌酐、白蛋白水平等指标两组间差异无统计学意义（P＞0.05）;血清钙、磷、iPTH达标率分别为83.76％、19.66％、40.17％.两组比较,老年组血清钙、磷、iPTH、ALP均不同程度的低于非老年组,差异有统计学意义（P＜0.05）.结论 老年组MHD患者CKD-MBD指标低于非老年组,提示两组患者CKD-MBD发生机制存在差异,老年患者容易合并低转运骨病（akinesis bone disease,ABD）.
