Objective: To investigate findings and value of quantitative MR in depression model of rats. Methods: Twenty male SD rats were divided into model group and control group randomly (10 rats in each group). The depressio...Objective: To investigate findings and value of quantitative MR in depression model of rats. Methods: Twenty male SD rats were divided into model group and control group randomly (10 rats in each group). The depression model of rats was erected by separation and chronic unpredictable stress. The behavior of rat was detected by open-field test and sucrose consumption. The MR images of brain tissues were produced in vivo rats with T 2-and diffusion-weighted imaging. The changes of body weight and behavior score and the values of T 2 and ADC of ROIs were compared between the two groups. Histological verification of hippocampal neuron damage was also performed under ultramicrosopy. Results: Compared with the control group, T 2 values in hippocampus prolonged 5.5%(P<0.05), ADC values in hippocampus and in temporal lobe cortex decreased 11.7% and 10.9%(P<0.01)respectively in the model group. Histologic data confirmed severe neuronal damage in the hippocampus of the model group. Conclusion: This study capitalized on diffusion-weighted imaging as a sensitive technique for the identification of neuronal damage in depression and it provides an experimental evidence of MRI in depression investigation and clinical application.展开更多
文摘Objective: To investigate findings and value of quantitative MR in depression model of rats. Methods: Twenty male SD rats were divided into model group and control group randomly (10 rats in each group). The depression model of rats was erected by separation and chronic unpredictable stress. The behavior of rat was detected by open-field test and sucrose consumption. The MR images of brain tissues were produced in vivo rats with T 2-and diffusion-weighted imaging. The changes of body weight and behavior score and the values of T 2 and ADC of ROIs were compared between the two groups. Histological verification of hippocampal neuron damage was also performed under ultramicrosopy. Results: Compared with the control group, T 2 values in hippocampus prolonged 5.5%(P<0.05), ADC values in hippocampus and in temporal lobe cortex decreased 11.7% and 10.9%(P<0.01)respectively in the model group. Histologic data confirmed severe neuronal damage in the hippocampus of the model group. Conclusion: This study capitalized on diffusion-weighted imaging as a sensitive technique for the identification of neuronal damage in depression and it provides an experimental evidence of MRI in depression investigation and clinical application.
