Objective： To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals....Objective： To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals. Methods： In this double blind, cross-over trial, 30 obese subjects were randomized to receive either curcumin （1 g/day） or placebo for a period of 30 days. Following a wash-out interval of 2 weeks, each subject was crossed over to the alternative regimen for a further 30 days. Severity of anxiety and depression was assessed at baseline and at weeks 4, 6 and 10 of the trial using the Beck Anxiety Inventory （BAI） and Beck Depression Inventory （BDI） scales, respectively. Results： Mean BAI score was found to be significantly reduced following curcumin therapy （P=0.03）. However, curcumin supplementation did not exert any significant impact on BDI scores （P=0.7）. Conclusion： Curcumin has a potential anti-anxiety effect in individuals with obesity.展开更多
目的观察丹参川芎嗪注射液联合缬沙坦治疗早期糖尿病肾病(DN)的临床疗效。方法将76例早期DN患者分为治疗组和对照组,各38例。两组患者均给予糖尿病饮食、控制血糖、降血压、调血脂等常规治疗,对照组患者在此基础上加服缬沙坦,治疗组患...目的观察丹参川芎嗪注射液联合缬沙坦治疗早期糖尿病肾病(DN)的临床疗效。方法将76例早期DN患者分为治疗组和对照组,各38例。两组患者均给予糖尿病饮食、控制血糖、降血压、调血脂等常规治疗,对照组患者在此基础上加服缬沙坦,治疗组患者在对照组基础上加用丹参川芎嗪注射液治疗,4周为1个疗程。观察两组患者治疗前后空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1C)及24 h尿白蛋白排泄率(UAER)、血浆超敏C反应蛋白(hs-CRP)的变化。结果治疗后,两组患者的FPG,2 h PG,Hb A1C,hs-CRP,UAER均较治疗前显著降低(P<0.05),且治疗组下降更明显(P<0.05)。结论丹参川芎嗪注射液联合缬沙坦治疗早期DN可有效改善糖代谢,增强外周胰岛素敏感性,降低hs-CRP水平,减少尿蛋白排泄,保护肾功能,延缓DN的进展,值得推广。展开更多
基金Support by the Research Council at the Mashhad University of Medical Sciences,Mashhad,Iran
文摘Objective： To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals. Methods： In this double blind, cross-over trial, 30 obese subjects were randomized to receive either curcumin （1 g/day） or placebo for a period of 30 days. Following a wash-out interval of 2 weeks, each subject was crossed over to the alternative regimen for a further 30 days. Severity of anxiety and depression was assessed at baseline and at weeks 4, 6 and 10 of the trial using the Beck Anxiety Inventory （BAI） and Beck Depression Inventory （BDI） scales, respectively. Results： Mean BAI score was found to be significantly reduced following curcumin therapy （P=0.03）. However, curcumin supplementation did not exert any significant impact on BDI scores （P=0.7）. Conclusion： Curcumin has a potential anti-anxiety effect in individuals with obesity.
文摘目的观察丹参川芎嗪注射液联合缬沙坦治疗早期糖尿病肾病(DN)的临床疗效。方法将76例早期DN患者分为治疗组和对照组,各38例。两组患者均给予糖尿病饮食、控制血糖、降血压、调血脂等常规治疗,对照组患者在此基础上加服缬沙坦,治疗组患者在对照组基础上加用丹参川芎嗪注射液治疗,4周为1个疗程。观察两组患者治疗前后空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1C)及24 h尿白蛋白排泄率(UAER)、血浆超敏C反应蛋白(hs-CRP)的变化。结果治疗后,两组患者的FPG,2 h PG,Hb A1C,hs-CRP,UAER均较治疗前显著降低(P<0.05),且治疗组下降更明显(P<0.05)。结论丹参川芎嗪注射液联合缬沙坦治疗早期DN可有效改善糖代谢,增强外周胰岛素敏感性,降低hs-CRP水平,减少尿蛋白排泄,保护肾功能,延缓DN的进展,值得推广。
