We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational st...We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.展开更多
Objective： To explore the beneficial regulatory effect of mild moxibustion from different distances at Zusanli（ST 36） of healthy population on the functions of temperature-related brain regions. Methods： In 20 rec...Objective： To explore the beneficial regulatory effect of mild moxibustion from different distances at Zusanli（ST 36） of healthy population on the functions of temperature-related brain regions. Methods： In 20 recruited healthy subjects, the change of the temperature-related brain regions induced by mild moxibustion from different distances at Zusanli（ST 36） was observed by functional magnetic resonance imaging（fM RI）. Results： In comparison of the values in amplitude of low-frequency fluctuation（fA LFF） during and before moxibustion, it has been found that in moxibustion of 2 cm distance, fA LFF value increased in the brain regions of the left anterior cingulated cortex and lateral surrounding cerebral regions, and fA LFF value decreased in the cerebral regions of the peripheral cortex of the calcarine fissure; in moxibustion of 3 cm distance, fA LFF value increased in the brain regions of the right and medial side and paracingulated gyrus, and fA LFF value decreased in the cerebral zone of the left middle temporal gyrus; in moxibustion of 4 cm distance, fA LFF value increased in the brain regions of the right and medial and paracingulated gyrus; and in moxibustion of 5 cm distance, fA LFF value increased in the brain regions of the left hippocampus. In comparison of the value of regional homogeneity（ReH o）, it has been found that in moxibustion of 2 cm distance, ReH o value increased in the cerebral zone of the posterior lobe of the right cerebellum, and ReH o value decreased in the cerebral zone of the right occipital lobe; in moxibustion of 3 cm distance, ReH o value increased in the brain regions of the left cerebellar posterior lobe and left frontal lobe, and ReH o value decreased in the cerebral zone of the right inferior temporal gyrus; in moxibustion of 4 cm distance, ReH o value increased in the brain regions of the right superior frontal gyrus and ReH o value decreased in the brain regions of the right parietal lobe and angular gyrus; in moxibustion of 5 cm distance, ReH o val展开更多
基金Supported by Key Project of Jiangxi Provincial Youth Science Foundation:to Explore the Analgesic Mechanism of Brain Functional Network Regulation of moxibustion on Heat-sensitive Acupoints Based on rfMRI and MRS(No.20192ACB21007)Jiangxi Province Introduces and Cultivates Innovative and Entrepreneurial High-level Talent Projects:Brain Functional Network Regulation and Neurobiochemical Mechanism of Heat-sensitive Moxibustion Analgesia(No.jxsq2019201104)。
文摘We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.
基金supported by National Basic Research Program of China,No.2015CB554502Graduate Student Research Innovation Project of Hunan Province,No.CX2016B351Research Study and In novative Experimental Planning Project of Hunan Province Undergraduates,No.NO221~~
文摘Objective： To explore the beneficial regulatory effect of mild moxibustion from different distances at Zusanli（ST 36） of healthy population on the functions of temperature-related brain regions. Methods： In 20 recruited healthy subjects, the change of the temperature-related brain regions induced by mild moxibustion from different distances at Zusanli（ST 36） was observed by functional magnetic resonance imaging（fM RI）. Results： In comparison of the values in amplitude of low-frequency fluctuation（fA LFF） during and before moxibustion, it has been found that in moxibustion of 2 cm distance, fA LFF value increased in the brain regions of the left anterior cingulated cortex and lateral surrounding cerebral regions, and fA LFF value decreased in the cerebral regions of the peripheral cortex of the calcarine fissure; in moxibustion of 3 cm distance, fA LFF value increased in the brain regions of the right and medial side and paracingulated gyrus, and fA LFF value decreased in the cerebral zone of the left middle temporal gyrus; in moxibustion of 4 cm distance, fA LFF value increased in the brain regions of the right and medial and paracingulated gyrus; and in moxibustion of 5 cm distance, fA LFF value increased in the brain regions of the left hippocampus. In comparison of the value of regional homogeneity（ReH o）, it has been found that in moxibustion of 2 cm distance, ReH o value increased in the cerebral zone of the posterior lobe of the right cerebellum, and ReH o value decreased in the cerebral zone of the right occipital lobe; in moxibustion of 3 cm distance, ReH o value increased in the brain regions of the left cerebellar posterior lobe and left frontal lobe, and ReH o value decreased in the cerebral zone of the right inferior temporal gyrus; in moxibustion of 4 cm distance, ReH o value increased in the brain regions of the right superior frontal gyrus and ReH o value decreased in the brain regions of the right parietal lobe and angular gyrus; in moxibustion of 5 cm distance, ReH o val
