t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshol...t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshold mechanoreceptors are located in the dorsal root ganglia and trigeminal ganglia, which extend a central projection innervating the spinal cord and brain stem and a peripheral projection innervating the specialized mechanosensory end organs. These specialized mechanosensory end organs include Meissner＇s corpuscles, Pacinian corpuscles, lanceolate endings, Merkel cells, and Ruffini corpuscles. The morphologies and physiological properties of these mechanosensory end organs and their innervating neurons have been investigated for over a century. In addition, recent advances in mouse genetics have enabled the identification of molecular mechanisms underlying the development of Aβ low- threshold mechanoreceptors, which highlight the crucial roles of neurotrophic factor signaling and transcription factor activity in this process. Here, we will review the anatomy, physiological properties, and development of mammalian low- threshold Aβ mechanoreceptors.展开更多
Somatosensory neurons of the dorsal root ganglia and trigeminal ganglia mediate various sensations from our body, including pain, itch, temperature, touch, and body position. One subset of these somatosensory neurons,...Somatosensory neurons of the dorsal root ganglia and trigeminal ganglia mediate various sensations from our body, including pain, itch, temperature, touch, and body position. One subset of these somatosensory neurons, the Aβ low-threshold mechanoreceptors, is designated for discriminative touch, such as sensing texture, vibration, and object shape. In a review on pages 408-420 of this issue, Fleming and Luo review the morphology, physiology, function, and development of different types of mammalian Aβ mechanoreceptors.展开更多
文摘t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshold mechanoreceptors are located in the dorsal root ganglia and trigeminal ganglia, which extend a central projection innervating the spinal cord and brain stem and a peripheral projection innervating the specialized mechanosensory end organs. These specialized mechanosensory end organs include Meissner＇s corpuscles, Pacinian corpuscles, lanceolate endings, Merkel cells, and Ruffini corpuscles. The morphologies and physiological properties of these mechanosensory end organs and their innervating neurons have been investigated for over a century. In addition, recent advances in mouse genetics have enabled the identification of molecular mechanisms underlying the development of Aβ low- threshold mechanoreceptors, which highlight the crucial roles of neurotrophic factor signaling and transcription factor activity in this process. Here, we will review the anatomy, physiological properties, and development of mammalian low- threshold Aβ mechanoreceptors.
文摘Somatosensory neurons of the dorsal root ganglia and trigeminal ganglia mediate various sensations from our body, including pain, itch, temperature, touch, and body position. One subset of these somatosensory neurons, the Aβ low-threshold mechanoreceptors, is designated for discriminative touch, such as sensing texture, vibration, and object shape. In a review on pages 408-420 of this issue, Fleming and Luo review the morphology, physiology, function, and development of different types of mammalian Aβ mechanoreceptors.
