一磷酸腺苷激活蛋白激酶（adenosine monophosphate activated protein kinase，AMPK）是一种能被AMP激活的蛋白激酶，在动物应激（生理、营养、环境和疾病等）过程中起着重要作用（Park等，2002）。近来研究表明，AMPK在糖代谢中起着...一磷酸腺苷激活蛋白激酶（adenosine monophosphate activated protein kinase，AMPK）是一种能被AMP激活的蛋白激酶，在动物应激（生理、营养、环境和疾病等）过程中起着重要作用（Park等，2002）。近来研究表明，AMPK在糖代谢中起着非常重要的作用，AMPK通过磷酸化作用抑制糖原合成酶，降低糖原的合成速率。展开更多
Sugar and protein are the major macronutrients＇ sources, and their balanced intake is important for animal＇s health. It has been observed that animals are able to change food preference in an imbalanced nutritional ...Sugar and protein are the major macronutrients＇ sources, and their balanced intake is important for animal＇s health. It has been observed that animals are able to change food preference in an imbalanced nutritional condition to selectively consume nutrients that are deficient in the body （Dethier, 1976）. Early studies in both Drosophila and mouse have demonstrated that animals exhibit food rejection to imbalanced diets lacking essential amino acids （Hao et al., 2005; Bjordal et al., 2014）. Furthermore, the food preference change upon protein depri- vation has been characterized using a two choice assay in Drosophila （Ribeiro and Dickson, 2010; Vargas et al., 2010）. Different from protein food, sugar is the main energy source, and sugar deficiency severely affects animal survival （Lee et al., 2008）. However, whether animals adopt a strategy of fast food preference switch upon sugar deprivation had not been investigated, and the neural mechanisms underlying this behavior regulation remain poorly understood.展开更多
文摘一磷酸腺苷激活蛋白激酶（adenosine monophosphate activated protein kinase，AMPK）是一种能被AMP激活的蛋白激酶，在动物应激（生理、营养、环境和疾病等）过程中起着重要作用（Park等，2002）。近来研究表明，AMPK在糖代谢中起着非常重要的作用，AMPK通过磷酸化作用抑制糖原合成酶，降低糖原的合成速率。
基金supported by the grants from the National Science Foundation of China(Nos. 91132709 and 31130027)
文摘Sugar and protein are the major macronutrients＇ sources, and their balanced intake is important for animal＇s health. It has been observed that animals are able to change food preference in an imbalanced nutritional condition to selectively consume nutrients that are deficient in the body （Dethier, 1976）. Early studies in both Drosophila and mouse have demonstrated that animals exhibit food rejection to imbalanced diets lacking essential amino acids （Hao et al., 2005; Bjordal et al., 2014）. Furthermore, the food preference change upon protein depri- vation has been characterized using a two choice assay in Drosophila （Ribeiro and Dickson, 2010; Vargas et al., 2010）. Different from protein food, sugar is the main energy source, and sugar deficiency severely affects animal survival （Lee et al., 2008）. However, whether animals adopt a strategy of fast food preference switch upon sugar deprivation had not been investigated, and the neural mechanisms underlying this behavior regulation remain poorly understood.
