OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer pa...OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer展开更多
扫描电子显微镜(scanning electron microscope,SEM)是表征高分子材料微观结构及其组成信息重要的手段之一,具有操作简便、信号电子种类多样且对样品损伤较小等特点.本文系统阐述了SEM的工作原理,通过与透射电子显微镜(transmission ele...扫描电子显微镜(scanning electron microscope,SEM)是表征高分子材料微观结构及其组成信息重要的手段之一,具有操作简便、信号电子种类多样且对样品损伤较小等特点.本文系统阐述了SEM的工作原理,通过与透射电子显微镜(transmission electron microscope,TEM)进行比较,突出了其优势与特色.详细讨论了该技术的测试方法,包括样品制备、仪器参数设定、操作技巧与图像处理,并揭示了获得高质量SEM图像的关键技术.介绍了SEM不同的信号电子成像、SEM与其他仪器联用及SEM原位分析技术在高分子材料表征中的应用与进展.最后,对SEM的发展趋势进行了展望.展开更多
基金supported by the Natural Science Foundation of Shanghai Science and Technology Commission (No. 17ZR1438800, for Dr. Xuan Liu)Traditional Chinese Medicine Guiding Project of Shanghai Science and Technology Commission (No . 13401907500 , for Zhi-feng Qin)+1 种基金Shanghai Municipal Commission of Health and Family Planning Program (No. ZY3-CCCX-3-3056, for Dr. Li-juan Xiu)National Natural Science Foundation Youth Program (No. 81603434, for Dr. Li-juan Xiu)
文摘OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer
文摘扫描电子显微镜(scanning electron microscope,SEM)是表征高分子材料微观结构及其组成信息重要的手段之一,具有操作简便、信号电子种类多样且对样品损伤较小等特点.本文系统阐述了SEM的工作原理,通过与透射电子显微镜(transmission electron microscope,TEM)进行比较,突出了其优势与特色.详细讨论了该技术的测试方法,包括样品制备、仪器参数设定、操作技巧与图像处理,并揭示了获得高质量SEM图像的关键技术.介绍了SEM不同的信号电子成像、SEM与其他仪器联用及SEM原位分析技术在高分子材料表征中的应用与进展.最后,对SEM的发展趋势进行了展望.
