OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer pa...OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer展开更多
基金supported by the Natural Science Foundation of Shanghai Science and Technology Commission (No. 17ZR1438800, for Dr. Xuan Liu)Traditional Chinese Medicine Guiding Project of Shanghai Science and Technology Commission (No . 13401907500 , for Zhi-feng Qin)+1 种基金Shanghai Municipal Commission of Health and Family Planning Program (No. ZY3-CCCX-3-3056, for Dr. Li-juan Xiu)National Natural Science Foundation Youth Program (No. 81603434, for Dr. Li-juan Xiu)
文摘OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer
基金support from the National Natural Science Foundation of China (No. 51825401)the Foundation of National Key Laboratory for Precision Hot Processing of Metals, China (No. JCKYS2021603C001)the Natural Science Foundation of Heilongjiang Province, China (No. LH2020E032)。
文摘背景超声在颈动脉斑块筛查、密度结构判定、稳定性评估等方面发挥着重要作用.剪切波超声弹性成像(shear wave elastography,SWE)作为一种全新的超声弹性成像方法,可通过分析剪切波传播速度来定量评估生物组织的弹性硬度信息.因此,运用SWE定量分析不同类型颈动脉斑块的硬度特征,可为临床评估斑块稳定性提供有价值的参考.目的运用SWE测定脂肪肝患者不同类型颈动脉斑块硬度,探讨其与血脂水平相关性.方法回顾性分析130例存在颈动脉单一斑块的脂肪肝患者临床资料,共计130个斑块.根据常规超声下斑块回声不同分为3组:软斑块组(40例)、混合性斑块组(52例)、硬斑块组(38例).对所有斑块行SWE检查,测量各斑块平均杨氏模量值,并分析其与低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)以及高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平的相关性.结果硬斑块组平均杨氏模量值、HDL-C水平明显高于混合性斑块组及软斑块组,差异有统计学意义(P<0.05);混合性斑块组平均杨氏模量值、HDL-C水平明显高于软斑块组,差异有统计学意义(P<0.05);硬斑块组LDL-C水平明显低于混合性斑块组及软斑块组,差异有统计学意义(P<0.05);混合性斑块组LDL-C水平明显低于软斑块组,差异有统计学意义(P<0.05);颈动脉斑块平均杨氏模量值与LDL-C水平呈负相关性(r=-0.71,P<0.05),与HDL-C水平呈正相关性(r=0.75,P<0.05).结论SWE能定量评估不同类型颈动脉斑块的软硬度,其平均杨氏模量值与血脂水平具有一定相关性,可为临床评估斑块稳定性提供硬度信息.
文摘目的探讨介入技术在老年胰源性门脉高压症(pancreatic portal hypertension,PPH)并发消化道出血中的治疗价值.方法选择2002-05/2016-05新昌县人民医院收治的65例老年PPH并发消化道出血患者,根据治疗方案不同,分为内镜治疗的对照组,和介入治疗的观察组,然后将两组患者的止血时间、输血量、1 wk内再次出血等指标及疗效情况进行比较.结果观察组患者的平均止血时间、平均输血量、1 wk内再出血发生率明显低于对照组(8.1h±1.5h vs 12.9h±1.3h、620mL±100mL vs 750mL±110mL、6.67%vs 14.29%),差异均有统计学意义(P<0.05);观察组患者的治疗总有效率为90%,显著高于对照组患者的68.57%,差异有统计学意义(P<0.05);两组患者在上腹部疼痛、脾脓肿、死亡等发生率上无明显差异,无统计学意义(P>0.05).结论老年PPH并发消化道出血的患者中,给予介入治疗方案,具有止血确切可靠的特点,提高治疗有效率,为该病的临床治疗提供更多参考.
