Background Recent studies have suggested that susceptibility to chronic obstructive pulmonary disease （COPD） might be related to the length polymorphism of （GT）n repeat in the 5＇-flanking region of heme oxygenase...Background Recent studies have suggested that susceptibility to chronic obstructive pulmonary disease （COPD） might be related to the length polymorphism of （GT）n repeat in the 5＇-flanking region of heme oxygenase-1 （HOX-1） gene. However, there has been no research about the relationship between the polymorphism of HOX-1 gene and severity of COPD. Methods The polymorphism of HOX-1 gene in 452 patients with COPD from Han population in Southwest China was analysed by fragment analysis. The frequencies of the HOX-1 genotype were compared with the stage of COPD of each patient. Results The HOX-1 genotypes were classified into two groups： group I were individuals with class L allele （the number of GT 〉32 repeats）, and group II were those without class L allele （the number of GT 〈32 repeats）. The genotypic frequency of the HOX-1 group I was significantly higher than group II in the very severe COPD patients （36.8% vs 22.4%, P〈0.01, OR=2.0, 95% CI 1.3-3.1）, while the genotypic frequency of the HOX-1 group II was lower in the mild COPD （16.0% vs 26.0%, P=-0.02, OR=0.5, 95% CI 0.3-0.9）. However, in moderate and severe stages COPD, there were similar genotypic frequencies between HOX-1 group Ⅰ and group Ⅱ. Conclusions Genetic polymorphism in HOX-1 is associated with the severity of COPD in Southwest China. COPD patients with class L allele may be susceptible to develop very severe COPD. Conversely, the COPD patients without class L allele may be more easily stabilized on mild COPD.展开更多
垂直数据分区技术从逻辑上将满足一定语义条件的数据库表属性存放在同一个物理块中,进而降低数据访问成本,提高查询效率.数据库查询负载中的每条查询通常只与数据库表中的部分属性有关,因此只需使用数据库表的某个属性子集便可以得到准...垂直数据分区技术从逻辑上将满足一定语义条件的数据库表属性存放在同一个物理块中,进而降低数据访问成本,提高查询效率.数据库查询负载中的每条查询通常只与数据库表中的部分属性有关,因此只需使用数据库表的某个属性子集便可以得到准确的查询结果.合理的垂直数据分区方式可以使大多数查询负载不需要扫描完整数据库就可以完成查询任务,从而达到减少数据访问量,提高查询处理效率的目的.传统的数据库垂直分区方法主要基于专家设置的启发式规则,分区策略粒度较粗,且不能根据负载的特征进行有针对性的分区优化.同时,当负载规模较大或者属性个数较多时,现有垂直分区方法执行时间过长,尤其无法满足数据库在线实时调优的性能需求.为此,提出在线环境下基于谱聚类的垂直数据分区方法(spectral clustering based vertical partitioning,SCVP),采用分阶段求解的思想,减少算法时间复杂度,加快分区执行速度.首先通过增加约束条件缩小解空间(即根据谱聚类生成初始分区),然后对解空间设计算法进行精细的搜索(即采用频繁项集和贪心搜索相结合的策略对初始分区进行优化).为了进一步提升SCVP在高维属性下的性能,提出了SCVP的改进版本SCVP-R(spectral clustering based vertical partitioning redesign).SCVP-R通过引入同域竞争机制、双败淘汰机制和循环机制,对SCVP在分区优化过程中的合并方案进行了进一步优化.在不同数据集上的实验结果表明,相比于目前最好的垂直分区方法,SCVP和SCVP-R有着更快的执行时间和更好的性能表现.展开更多
目的探讨球囊扩张或血管支架补救治疗对急性大脑中动脉M1段机械取栓治疗失败患者的安全性和有效性,并分析患者预后的影响因素。方法回顾性分析2014年1月至2018年6月中国人民解放军陆军军医大学第二附属医院综合卒中中心和其他19家综合...目的探讨球囊扩张或血管支架补救治疗对急性大脑中动脉M1段机械取栓治疗失败患者的安全性和有效性,并分析患者预后的影响因素。方法回顾性分析2014年1月至2018年6月中国人民解放军陆军军医大学第二附属医院综合卒中中心和其他19家综合卒中中心80例急性大脑中动脉M1段机械取栓治疗失败并行补救治疗达到闭塞血管血流改良脑梗死溶栓分级(modi?ed thrombolysis in cerebral infarction score,m TICI)≥2b级患者的临床资料,根据补救治疗方法将其分为球囊扩张组(30例)和血管支架植入组(50例)。比较两组患者90 d改良Rankin量表(modi?ed Rankin scale,m RS)评分、血管再闭塞率、症状性颅内出血发生率及死亡率,并对影响患者预后的相关因素进行多因素Logistic回归分析。结果球囊扩张组中90 d mRS评分0～2分患者占比明显高于血管支架植入组(P <0.05);两组患者血管再闭塞率、死亡率及症状性颅内出血发生率比较均无显著差异(P_均> 0.05)。多因素Logistic回归分析显示:卒中病史(OR=8.968,95%CI:1.162～69.196,P=0.035)、补救治疗方式(OR=0.243,95%CI:0.066～0.894,P=0.033)、侧支循环(OR=3.873,95%CI:1.029～14.576,P=0.045)及基线美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分(OR=0.809,95%CI:0.701～0.934,P=0.004)均为急性大脑中动脉M1段闭塞取栓失败后行补救治疗患者神经功能预后的独立危险因素(P_均<0.05)。结论机械取栓联合球囊扩张能够有效改善急性大脑中动脉M1段闭塞性缺血性脑卒中患者神经功能,并未增加手术风险,且补救治疗方式是影响患者治疗后神经功能的独立危险因素。展开更多
Objective: To observe the clinical effects of Babaodan Capsule(八宝丹, BBD) combined with Qingyi Huaji Formula(清胰化积方, QYHJ) in treating patients with advanced pancreatic cancer. Methods: Eighty-one patients with ...Objective: To observe the clinical effects of Babaodan Capsule(八宝丹, BBD) combined with Qingyi Huaji Formula(清胰化积方, QYHJ) in treating patients with advanced pancreatic cancer. Methods: Eighty-one patients with advanced pancreatic cancer(from January 1, 2013 to December 31, 2014) were enrolled. Patients were assigned to two groups: QYHJ plus BBD group(40 cases) and QYHJ only group(41 cases), and there were no significant differences for other treatment between two groups. The survival and cancer-related symptoms were compared between two groups over two cycles of treatment. Results: The cancer-related symptoms of patients such as ascites, jaundice, pain, abdominal distension, anorexia and Karnofsky performance status of QYHJ plus BBD group were significantly improved as compared with those of the QYHJ group(P<0.01). In addition, the 1-year survival rate of patients in QYHJ plus BBD group was longer than that in the QYHJ group(65% vs. 33%, respectively, P=0.0023). Conclusions: BBD with QYHJ is feasible treatment to prolong the survival of patients with advanced pancreatic cancer. However, it deserves to be further investigated in randomized clinical trials.展开更多
Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative s...Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative system concepts in X-ray and computer tomography. This paper proposes a novel electron beam focusing, shaping,and deflection electron gun for distributed X-ray sources.The electron gun uses a dispenser cathode as an electron emitter, a mesh grid to control emission current, and two electrostatic lenses for beam shaping, focusing, and deflection. Novel focusing and deflecting electrodes were designed to increase the number of focal spots in the distributed source. Two identical half-rectangle opening electrodes are controlled by adjusting the potential of the two electrodes to control the electron beam trajectory, and then, multifocal spots are obtained on the anode target. The electron gun can increase the spatial density of the distributed X-ray sources, thereby improving the image quality. The beam experimental results show that the focal spot sizes of the deflected(deflected amplitude 10.5 mm)and non-deflected electron beams at full width at half maximum are 0.80 mm 90.50 mm and 0.55 mm 90.40 mm, respectively(anode voltage 160 kV; beam current 30 mA). The imaging experimental results demonstrate the excellent spatial resolution and time resolution of an imaging system built with the sources, which has an excellent imaging effect on a field-programmable gate array chip and a rotating metal disk.展开更多
文摘Background Recent studies have suggested that susceptibility to chronic obstructive pulmonary disease （COPD） might be related to the length polymorphism of （GT）n repeat in the 5＇-flanking region of heme oxygenase-1 （HOX-1） gene. However, there has been no research about the relationship between the polymorphism of HOX-1 gene and severity of COPD. Methods The polymorphism of HOX-1 gene in 452 patients with COPD from Han population in Southwest China was analysed by fragment analysis. The frequencies of the HOX-1 genotype were compared with the stage of COPD of each patient. Results The HOX-1 genotypes were classified into two groups： group I were individuals with class L allele （the number of GT 〉32 repeats）, and group II were those without class L allele （the number of GT 〈32 repeats）. The genotypic frequency of the HOX-1 group I was significantly higher than group II in the very severe COPD patients （36.8% vs 22.4%, P〈0.01, OR=2.0, 95% CI 1.3-3.1）, while the genotypic frequency of the HOX-1 group II was lower in the mild COPD （16.0% vs 26.0%, P=-0.02, OR=0.5, 95% CI 0.3-0.9）. However, in moderate and severe stages COPD, there were similar genotypic frequencies between HOX-1 group Ⅰ and group Ⅱ. Conclusions Genetic polymorphism in HOX-1 is associated with the severity of COPD in Southwest China. COPD patients with class L allele may be susceptible to develop very severe COPD. Conversely, the COPD patients without class L allele may be more easily stabilized on mild COPD.
文摘垂直数据分区技术从逻辑上将满足一定语义条件的数据库表属性存放在同一个物理块中,进而降低数据访问成本,提高查询效率.数据库查询负载中的每条查询通常只与数据库表中的部分属性有关,因此只需使用数据库表的某个属性子集便可以得到准确的查询结果.合理的垂直数据分区方式可以使大多数查询负载不需要扫描完整数据库就可以完成查询任务,从而达到减少数据访问量,提高查询处理效率的目的.传统的数据库垂直分区方法主要基于专家设置的启发式规则,分区策略粒度较粗,且不能根据负载的特征进行有针对性的分区优化.同时,当负载规模较大或者属性个数较多时,现有垂直分区方法执行时间过长,尤其无法满足数据库在线实时调优的性能需求.为此,提出在线环境下基于谱聚类的垂直数据分区方法(spectral clustering based vertical partitioning,SCVP),采用分阶段求解的思想,减少算法时间复杂度,加快分区执行速度.首先通过增加约束条件缩小解空间(即根据谱聚类生成初始分区),然后对解空间设计算法进行精细的搜索(即采用频繁项集和贪心搜索相结合的策略对初始分区进行优化).为了进一步提升SCVP在高维属性下的性能,提出了SCVP的改进版本SCVP-R(spectral clustering based vertical partitioning redesign).SCVP-R通过引入同域竞争机制、双败淘汰机制和循环机制,对SCVP在分区优化过程中的合并方案进行了进一步优化.在不同数据集上的实验结果表明,相比于目前最好的垂直分区方法,SCVP和SCVP-R有着更快的执行时间和更好的性能表现.
文摘目的探讨球囊扩张或血管支架补救治疗对急性大脑中动脉M1段机械取栓治疗失败患者的安全性和有效性,并分析患者预后的影响因素。方法回顾性分析2014年1月至2018年6月中国人民解放军陆军军医大学第二附属医院综合卒中中心和其他19家综合卒中中心80例急性大脑中动脉M1段机械取栓治疗失败并行补救治疗达到闭塞血管血流改良脑梗死溶栓分级(modi?ed thrombolysis in cerebral infarction score,m TICI)≥2b级患者的临床资料,根据补救治疗方法将其分为球囊扩张组(30例)和血管支架植入组(50例)。比较两组患者90 d改良Rankin量表(modi?ed Rankin scale,m RS)评分、血管再闭塞率、症状性颅内出血发生率及死亡率,并对影响患者预后的相关因素进行多因素Logistic回归分析。结果球囊扩张组中90 d mRS评分0～2分患者占比明显高于血管支架植入组(P <0.05);两组患者血管再闭塞率、死亡率及症状性颅内出血发生率比较均无显著差异(P_均> 0.05)。多因素Logistic回归分析显示:卒中病史(OR=8.968,95%CI:1.162～69.196,P=0.035)、补救治疗方式(OR=0.243,95%CI:0.066～0.894,P=0.033)、侧支循环(OR=3.873,95%CI:1.029～14.576,P=0.045)及基线美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分(OR=0.809,95%CI:0.701～0.934,P=0.004)均为急性大脑中动脉M1段闭塞取栓失败后行补救治疗患者神经功能预后的独立危险因素(P_均<0.05)。结论机械取栓联合球囊扩张能够有效改善急性大脑中动脉M1段闭塞性缺血性脑卒中患者神经功能,并未增加手术风险,且补救治疗方式是影响患者治疗后神经功能的独立危险因素。
基金Supported by the National Natural Science Foundation of China(No.81173461)Development Project of the China Postdoctoral Science Foundation(No.2015M581532)
文摘Objective: To observe the clinical effects of Babaodan Capsule(八宝丹, BBD) combined with Qingyi Huaji Formula(清胰化积方, QYHJ) in treating patients with advanced pancreatic cancer. Methods: Eighty-one patients with advanced pancreatic cancer(from January 1, 2013 to December 31, 2014) were enrolled. Patients were assigned to two groups: QYHJ plus BBD group(40 cases) and QYHJ only group(41 cases), and there were no significant differences for other treatment between two groups. The survival and cancer-related symptoms were compared between two groups over two cycles of treatment. Results: The cancer-related symptoms of patients such as ascites, jaundice, pain, abdominal distension, anorexia and Karnofsky performance status of QYHJ plus BBD group were significantly improved as compared with those of the QYHJ group(P<0.01). In addition, the 1-year survival rate of patients in QYHJ plus BBD group was longer than that in the QYHJ group(65% vs. 33%, respectively, P=0.0023). Conclusions: BBD with QYHJ is feasible treatment to prolong the survival of patients with advanced pancreatic cancer. However, it deserves to be further investigated in randomized clinical trials.
文摘Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative system concepts in X-ray and computer tomography. This paper proposes a novel electron beam focusing, shaping,and deflection electron gun for distributed X-ray sources.The electron gun uses a dispenser cathode as an electron emitter, a mesh grid to control emission current, and two electrostatic lenses for beam shaping, focusing, and deflection. Novel focusing and deflecting electrodes were designed to increase the number of focal spots in the distributed source. Two identical half-rectangle opening electrodes are controlled by adjusting the potential of the two electrodes to control the electron beam trajectory, and then, multifocal spots are obtained on the anode target. The electron gun can increase the spatial density of the distributed X-ray sources, thereby improving the image quality. The beam experimental results show that the focal spot sizes of the deflected(deflected amplitude 10.5 mm)and non-deflected electron beams at full width at half maximum are 0.80 mm 90.50 mm and 0.55 mm 90.40 mm, respectively(anode voltage 160 kV; beam current 30 mA). The imaging experimental results demonstrate the excellent spatial resolution and time resolution of an imaging system built with the sources, which has an excellent imaging effect on a field-programmable gate array chip and a rotating metal disk.
