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Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis 被引量:20
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作者 xuan liu li-juan xiu +13 位作者 jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue 《Journal of Integrative Medicine》 SCIE CAS CSCD 2017年第6期469-475,共7页
OBJECTIVE: Traditional Chinese medicine (TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer pa... OBJECTIVE: Traditional Chinese medicine (TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status (KPS) score were measured as the main outcome. RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups (x2 = 42.244, P 〈 0.001 ). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively (P 〈 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer 展开更多
关键词 stomach neoplasms drug therapy combination medicine Chinese traditional integrativemedicine plants medicinal
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阅读时戴低度凸透镜对小学生近视干预效果评价 被引量:2
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作者 胥芹 姜舒莹 +5 位作者 王超 段佳丽 宋玉珍 赵宏 吴立娟 郭秀花 《眼科》 CAS CSCD 北大核心 2016年第5期294-298,共5页
目的 评价阅读时戴低度凸透镜对小学生近视的干预效果。 设计 前瞻性队列研究。 研究对象 594例1-5年级的近视高危(双眼裸眼视力≥4.7,-1.0 D≤双眼等效球镜值≤2.0 D)的小学生。阅读时戴低度凸透镜者286例为干预组,平均年龄(7.81... 目的 评价阅读时戴低度凸透镜对小学生近视的干预效果。 设计 前瞻性队列研究。 研究对象 594例1-5年级的近视高危(双眼裸眼视力≥4.7,-1.0 D≤双眼等效球镜值≤2.0 D)的小学生。阅读时戴低度凸透镜者286例为干预组,平均年龄(7.81±1.48)岁;未戴低度凸透镜者308例为对照组,平均年龄(8.44±1.59)岁。方法 2010年底(基线)和2011年底(终线)分别对594例1-5年级的小学生行屈光度检查。根据终线时的检查结果(取右眼数据),以近视进展情况(终线右眼等效球镜-基线右眼等效球镜)、近视发病情况作为结局指标,分别采用多重线性回归分析和logistic回归分析评价干预效果,并且按照性别和年级(1-3年级VS 4-5年级)进行分层分析。主要指标 右眼等效球镜度数。结果 干预前后干预组右眼等效球镜变化(-0.35±0.76)D,较对照组(-0.56±0.71)D少(P=0.004)。女生干预组较对照组有效(P=0.003),男生干预组与对照组无统计学差异(P=0.317)。1-3年级干预组较对照组有效(P〈0.001),而4-5年级干预组与对照组无统计学差异(P=0.678)。终线时,干预组和对照组近视发病率分别为14.3%和29.5%。与对照组相比,干预组近视发病的OR值为0.593(95%CI=0.371-0.946);按性别分层,男生和女生干预组近视发病的OR值分别为0.704 (95%CI=0.358-1.385)和0.450(95%CI=0.227-0.894);按年级分层,1-3年级和4-5年级干预组近视发病的OR值分别为0.440(95%CI=0.238-0.813)和1.143(95%CI=0.478-2.731)。结论 阅读时戴低度凸透镜,尤其是女学生和低年级学生,可以减缓近视发展的进程,降低近视发病率,对小学生近视防治起到积极的作用。(眼科,2016, 25:294-298) 展开更多
关键词 近视 干预性研究 低度凸透镜 小学生
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