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Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants 被引量:9
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作者 Zhaosheng Kong Motohide Ioki +8 位作者 Siobhan Braybrook Shundai Li Zheng-Hua Ye Yuh-Ru Julie Lee Takashi Hotta anny Chang Juan Tian Guangda Wang Bo Liu 《Molecular Plant》 SCIE CAS CSCD 2015年第7期1011-1023,共13页
In plants, anisotropic cell expansion depends on cortical microtubules that serve as tracks along which macromolecules and vesicles are transported by the motor kinesins of unknown identities. We used cotton (Gossypi... In plants, anisotropic cell expansion depends on cortical microtubules that serve as tracks along which macromolecules and vesicles are transported by the motor kinesins of unknown identities. We used cotton (Gossypium hirsutum) fibers that underwent robust elongation to discover kinesins that are involved in cell elongation and found Gh KINESIN-4A expressed abundantly. The motor was detected by immunofluores- cence on vesicle-like structures that were associated with cortical microtubules. In Arabidopsis thaliana, the orthologous motor At KINESIN-4A/FRA1, previously implicated in cellulose deposition during second- ary growth in fiber cells, was examined by live-cell imaging in cells expressing the fluorescently tagged functional protein. The motor decorated vesicle-like particles that exhibit a linear movement along cortical microtubules with an average velocity of 0.89 l^m/min, which was significantly different from those linked to cellulose biosynthesis. We also discovered that At KINESIN-4A/FRA1 and the related At KINESIN-4C play redundant roles in cell wall mechanics, cell elongation, and the axial growth of various vegetative and reproductive organs, as the loss of At KINESIN-4C greatly enhanced the defects caused by a null mutation at the KINESIN-4A/FRA 1 locus. The double mutant displayed a lack of cell wall softening at normal stages of rapid cell elongation. Furthermore, enhanced deposition of arabinose-containing carbohydrate was detected in the kinesin-4 mutants. Our findings established a connection between the Kinesin-4-based transport of cargoes containing non-cellulosic components along cortical microtubules and cell wall mechanics and cell elongation in flowering plants. 展开更多
关键词 CYTOSKELETON cytoskeleton-cell wall interactions leaf/vegetative development ARABIDOPSIS cotton
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Human pluripotent stem cell-derived extracellular vesicles:From now to the future
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作者 Bruno Moises de Matos Marco Augusto Stimamiglio +1 位作者 Alejandro Correa anny Waloski Robert 《World Journal of Stem Cells》 SCIE 2023年第5期453-465,共13页
Extracellular vesicles(EVs)are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools.Accordingly,in various biological contexts,EVs are re... Extracellular vesicles(EVs)are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools.Accordingly,in various biological contexts,EVs are reported to engage in immune modulation,senescence,and cell proliferation and differentiation.Therefore,EVs could be key elements for potential off-the-shelf cell-free therapy.Little has been studied regarding EVs derived from human pluripotent stem cells(hPSC-EVs),even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative ability.In this review article,we provide an overview of studies using hPSC-EVs,focusing on identifying the conditions in which the cells are cultivated for the isolation of EVs,how they are characterized,and applications already demonstrated.The topics reported in this article highlight the incipient status of the studies in the field and the significance of hPSC-EVs’prospective applications as PSC-derived cell-free therapy products. 展开更多
关键词 Pluripotent stem cells Extracellular vesicles EXOSOME Cell-free therapy
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A Laurentian affinity for the Embu Terrane,Ribeira Belt(SE Brazil),revealed by zircon provenance statistical analysis
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作者 Bruno V.Ribeiro Frederico M.Faleiros +10 位作者 Ginaldo A.C.Campanha Peter A.Cawood Christopher L.Kirkland Milo Barham Erin L.Martin Marina Seraine Dina I.G.Cabrita Maria T.A.G.Yogi VidyãV.Almeida anny J.A.Forero-Ortega Elton L.Dantas 《Geoscience Frontiers》 SCIE CAS CSCD 2023年第1期149-161,共13页
New and compiled detrital zircon U-Pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apia&#... New and compiled detrital zircon U-Pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apiaíand São Roque terranes with cratonic affinity(e.g.,São Francisco Craton).Zircon provenance results indicate that the type-area of the Embu Terrane is dominated by detrital zircon age modes at ca.1200 Ma,1400 Ma,and 1800 Ma,with maximum depositional age of ca.1000 Ma.In contrast,the Apiaíand São Roque terranes are dominated by Paleoproterozoic detrital zircon ages(ca.2200-2000 Ma age dominant component),with maximum depositional ages of ca.1400 Ma and 1750 Ma,respectively.Multidimensional scaling(MDS)analysis of non-parametric similarity measurements on zircon age populations indicates for the first time that the Embu Terrane encompass two statistically distinct detrital zircon age spectra,which is also reflected in the metamorphic zircon age record.The statistical characterization of the Embu Terrane through populational metrics allow a quantitative comparison with surrounding tectonic domains and rock samples classified such as Embu-type.Our results clearly highlight the distinction between the statistically differentiated Embu Terrane from the Apiaíand São Roque terranes,supporting an allochthonous interpretation.In addition,we demonstrate that rocks samples previously classified as Embu-type are significantly dissimilar to the definition of Embu Terrane,failing to support alternative tectonic models(e.g.,intracontinental evolution).Detrital zircon age spectra reveal that the Apiaíand São Roque terranes have similar zircon provenance to domains sourced from the São Francisco Craton,whereas detrital zircon populations from the Embu Terrane have greater affinity with SW Laurentia basins(and their inferred sediment sources),consistent with previous findings.Therefore,we interpret the Embu Terrane as a Rodinia descendant developed along the active margin of the SW Laurentia that collided with 展开更多
关键词 Ribeira belt Embu terrane Detrital zircon Multidimensional scaling Rodinia and gondwana PALEOGEOGRAPHY
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Consultation, Diagnosis and Treatment Delays for Breast Cancer among Patients Followed up at the YaoundéGeneral Hospital, Cameroon 被引量:1
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作者 Jean Dupont Kemfang Ngowa Angèle Kabeyene +7 位作者 Richard Ngarvounsia Etienne Atenguena Yvan Sinclair Ngaha Tchawe anny Ngassam Christiane Nsahlai Junie Metogo Jovanny Fouogue Tsuala Pierre Marie Tebeu 《Open Journal of Obstetrics and Gynecology》 2020年第11期1580-1589,共10页
<strong>Introduction</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</str... <strong>Introduction</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</strong></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> Breast cancer is often diagnosed at an advanced stage in Cameroon. The objective was to analyse consultation, diagnosis and treatment delays for breast cancer among patients followed up at the Yaoundé General Hospital (YGH) in Cameroon. </span><b><span style="font-family:Verdana;">Materials</span></b> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Methods</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> This was a cross-sectional study carried out from the files of patients followed up for breast cancer at the YGH from January 1, 2014 to April 30, 2018. A total of 183 patients were included. We measured time elapsed between the awareness of first signs of disease and the in</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">i</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">tial consultation (consultation delays), time lapse between the initial consultation and pathological diagnosis of breast cancer (diagnosis delays), interval between pathological diagnosis and treatment onset (treatment delays), time elapsed between the initial consultation and management (health system delays) and time elapsed from awareness of first signs of disease to treatment onset (overall delays). </span><b><span style="font-family:Verdana;">Results</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span>< 展开更多
关键词 Breast Cancer Delay in Consultation Delay in Diagnosis Delay in Treatment
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Analysis of Types and Causes of Traumatic Dental Injuries to Permanent Dentition among Patients Attending Tertiary Care Hospital of Pakistan 被引量:1
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作者 Mahwish Memon Mowaffaq Abdullmomen Al Absi +2 位作者 Zahid Hussain Siya anny Memon Abdul Ghani Shaikh 《Open Journal of Stomatology》 2020年第8期211-217,共7页
<b><span>Objective:</span></b><span> This study aimed to evaluate the age, gender, causes, place of trauma, and type of crown fracture in permanent dentition among patients </span>&... <b><span>Objective:</span></b><span> This study aimed to evaluate the age, gender, causes, place of trauma, and type of crown fracture in permanent dentition among patients </span><span>attending Liaquat University of Medical and Health Sciences Hospital (LUMHS)</span><span>, Jamshoro, Pakistan.</span><span> </span><b><span>Methodology:</span></b><span> This cross-sectional study was conducted at the Operative Dentistry Department of LUMHS hospital over a period of six months. All patients (6</span><span> </span><span>-</span><span> </span><span>40 years of age) who had a history of dental trauma and attending dental OPD were included in this study. The data for all patients were recorded in a predesigned proforma. Data were collected on age, gender, place of trauma (playground, road, home), cause of trauma (fall, playing, road accident, bicycle accident, collisions, fighting) and associated symptoms. The data w</span><span>ere</span><span> analyzed using SPSS 22.0. Mean and the standard deviation w</span><span>as </span><span>computed for a quantitative variable like age. Frequency and percentage were calculated for qualitative variables like gender, risk factors, and pattern of trauma. </span><b><span>Results:</span></b><span> A total of 82 patients were enrolled. The most frequent age group involved was 13</span><span> </span><span>-</span><span> </span><span>20 years (46%) with males (58.5%) predominance. The majority of trauma cases were due to fall (36.6%) while playing and 19.5% were bicycle accidents. The most commonly affected tooth was right maxillary central incisor (46.6%) followed by left maxillary central incisor (28.4%). Of the 116 teeth examined, 56.0% had a complicated crown fracture and 44.0% had an uncomplicated crown fracture</span><span>. </span><b><span>Conclusion:</span></b><span> </span><span>Safety measures should be implemented where dental traumatic accidents occur most frequently like </span><span>at</span><span> </span><span>home and on the roads.</span> 展开更多
关键词 Dental Trauma Crown Fracture FALL Public Safety
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ETM-IoT:Energy-Aware Threshold Model for Heterogeneous Communication in the Internet of Things 被引量:2
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作者 A.Vijaya Krishna A.anny Leema 《Computers, Materials & Continua》 SCIE EI 2022年第1期1815-1827,共13页
The internet of things(IoT)has a wide variety of applications,which in turn raisesmany challenging issues.IoT technology enables devices to closely monitor their environment,providing context-aware intelligence based ... The internet of things(IoT)has a wide variety of applications,which in turn raisesmany challenging issues.IoT technology enables devices to closely monitor their environment,providing context-aware intelligence based on the real-time data collected by their sensor nodes.The IoT not only controls these devices but also monitors their user’s behaviour.One of the major issues related to IoT is the need for an energy-efficient communication protocol which uses the heterogeneity and diversity of the objects connected through the internet.Minimizing energy consumption is a requirement for energyconstrained nodes and outsourced nodes.The IoT nodes deployed in different geographical regions typically have different energy levels.This paper focuses on creating an energy-efficient protocol for IoTwhich can deal with the clustering of nodes and the cluster head selection process.An energy thresholdmodel is developed to select the appropriate cluster heads and also to ensure uniform distribution of energy to those heads andmember nodes.The proposed model envisages an IoT network with three different types of nodes,described here as advanced,intermediate and normal nodes.Normal nodes are first-level nodes,which have the lowest energy use;intermediate nodes are second-level nodes,which have a medium energy requirement;and the advanced class are thirdlevel nodes with the highest energy use.The simulation results demonstrate that the proposed algorithm outperforms other existing algorithms.In tests,it shows a 26%improvement in network lifetime compared with existing algorithms. 展开更多
关键词 Internet of things COMMUNICATION energy THRESHOLD heterogeneous network
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Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells 被引量:3
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作者 Cintia DS Horinouchi María Julia Barisón +3 位作者 anny W Robert Crisciele Kuligovski Alessandra M Aguiar BrunoDallagiovanna 《World Journal of Stem Cells》 SCIE 2020年第12期1640-1651,共12页
BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of seve... BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several diseases.However,for successful clinical application,it is critical that high-quality cells can be obtained.Diverse factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as age.Nevertheless,there is no consensus regarding this characteristic,and there is conflicting information in the literature.AIM To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young donors.METHODS hASCs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).Cells were distributed into two groups according to age range:old hASCs(oASCs,≥55 years,n=9)and young hASCs(yASCs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow cytometry.Population doubling time was assessed over seven days.For adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic induction.Osteogenic potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic induction.mRNA expression of PPARγ2,CEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain reaction.RESULTS hASCs were successfully obtained,cultured,and grouped according to their age:yASCs(26.33±4.66 years old)and oASCs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old donors.Additionally,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal cells.The average doubling time indicated that yASCs(4.09±0.94 d)did not significantly differ from oASCs(4.19±1.29 d).Concerning differentiation potential,after adipogenic and osteogeni 展开更多
关键词 Adipose-derived stem cells Stem cells ADIPOGENESIS OSTEOGENESIS Cell differentiation Donor age
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A Literature Review—<i>Khaya senegalensis, Anacardium ouest</i>L., <i>Cassia sieberiana</i>DC., <i>Pterocarpus erinaceus</i>, <i>Diospyros mespiliformis</i>, <i>Ocimum gratissimum</i>, <i>Manihot esculenta</i>, <i>Vernonia amygdalina</i>Delile, <i>Pseudocedrela kotschyi</i>and <i>Daniellia oliveri</i>Possess Properties for Managing Infectious Diarrhea
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作者 Victorien Dougnon Edna Hounsa +9 位作者 Hornel Koudokpon Brice Boris Legba Kafayath Fabiyi Kevin Sintondji anny Afaton Merveille Akouta Jean Robert Klotoe Honoré Bankole Lamine Baba-Moussa Jacques Dougnon 《Advances in Bioscience and Biotechnology》 2020年第10期457-473,共17页
The rise in antimicrobial resistance increases researchers’ interest </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;"> medicinal plants... The rise in antimicrobial resistance increases researchers’ interest </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;"> medicinal plants used for traditional treatment of infectious diseases. The study is based on ten (10) medicinal plants mostly cited in the treatment of diarrhea in West Africa: </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">Khaya senegalensis</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Anacardium ouest</span></i></span><span style="font-family:Verdana;"></i></span><span style="font-family:Verdana;"> L., </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">Cassia sieberiana</span></i><span style="font-family:Verdana;"></i></span><span style="font-family:Verdana;"> DC., </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">Pterocarpus erinaceus</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Diospyros mespiliformis</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Ocimum gratissimum</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Manihot esculenta</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Vernonia amygdalina Delile</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Pseudocedrela kotschyi</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> Daniellia oliveri</span></i></span><span style="font-family:Verdana;"></i></span><span style="font-family:Verdana;">. The objective is to make a review on ethnopharmacological, pharmacological, toxicological and chemical data that enhance these medicinal plants in the fight against diarrheal infections. Specific keywords were used for bibliographic rese 展开更多
关键词 Infectious Diarrhea West Africa Medicinal Plants
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Breast Cancer Survival in Cameroon: Analysis of a Cohort of 404 Patients at the YaoundéGeneral Hospital 被引量:2
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作者 Jean Dupont Kemfang Ngowa Jean Marie Kasia +5 位作者 Jean Yomi Achille Nkigoum Nana anny Ngassam Irenée Domkam Zacharie Sando Paul Ndom 《Advances in Breast Cancer Research》 2015年第2期44-52,共9页
This study aimed to estimate the survival rate of breast cancer in a group of patients followed up at the Yaoundé General Hospital in Cameroon. A retrospective review of records of patients managed for breast can... This study aimed to estimate the survival rate of breast cancer in a group of patients followed up at the Yaoundé General Hospital in Cameroon. A retrospective review of records of patients managed for breast cancer between 1995 and 2007 was carried out at the Yaoundé General Hospital. Survival analysis was carried out with survival defined as the time between the date of unequivocal diagnosis of cancer and the date of last follow-up or death. Survival curves were plotted in R.3.1.1 software. Mean age of the patients was 47.5 ± 12.36 years. Most of the patients (67.9%) presented with advanced breast cancer disease (stage III and IV). Overall patient survival rate was 30% at 5 years and 13.2% at 10 years. Median overall survival time was 2 (1.9 - 3) years. There was a correlation between survival and the stage of disease. The highest survival rates were recorded in stages I and II while the lowest rates were recorded in stage IV. There was no statistically significant difference in survival among the age groups (p = 0.15). Overall survival rates of breast cancer are 30% at 5 years and 13.2% at 10 years among Cameroonian patients and are lower compared with 90% and 82% respectively at 5 years and 10 years in some developed countries. 展开更多
关键词 SURVIVAL BREAST CANCER DEVELOPING COUNTRIES
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老挝知识产权保护研究 被引量:2
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作者 黄璐 李志东 +4 位作者 丁科 张思佳 anny Bounmada 熊周权 杨爽 《现代情报》 CSSCI 2013年第8期79-83,共5页
随着老挝成为PCT条约缔约国以及WTO成员国,老挝知识产权工作越来越受到政府重视,本文浅述了老挝的知识产权保护工作,并对老挝知识产权法律制度的发展、老挝知识产权工作现状、老挝专利与商标保护等进行了研究,并重点对老挝专利制度与中... 随着老挝成为PCT条约缔约国以及WTO成员国,老挝知识产权工作越来越受到政府重视,本文浅述了老挝的知识产权保护工作,并对老挝知识产权法律制度的发展、老挝知识产权工作现状、老挝专利与商标保护等进行了研究,并重点对老挝专利制度与中国专利制度进行了比较研究,以期为未来中老两国在知识产权领域的研究与合作提供参考依据。 展开更多
关键词 老挝 专利 商标 知识产权 专利权
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Incidence and Risk Factors of Obstetric Anal Sphincter Injuries after Various Modes of Vaginal Deliveries in Chinese Women 被引量:2
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作者 Tung Chi Wai Cheon Willy Cecilia Tong Wai Mei anny Leung Hau Yee 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第18期2420-2425,共6页
Background: Obstetric anal sphincter injuries (OASIS) can cause an adverse impact on women's physical and mental health. There was lack of published data in Chinese population particularly on studying the risk of ... Background: Obstetric anal sphincter injuries (OASIS) can cause an adverse impact on women's physical and mental health. There was lack of published data in Chinese population particularly on studying the risk of OASIS for nonrotational outlet forceps. This study was to determine the incidence and risk factors of OASIS. Methods: This is a retrospective cohort study carried out in a tertiary referral hospital in Hong Kong. The control group was selected randomly. Univariate and multivariate logistic regression analysis was performed to evaluate the influence of potential risk factors on OASIS. This study reviewed the obstetric records of OASIS women and random control from January 2011 to June 2014. Univariate and multivariate logistic regression analysis was performed to evaluate the influence of potential risk factors on OASIS. Results: Of 15,446 women delivered, 49 had OASIS. The percentage of OASIS increased from 0.3% (2011) to 0.38% (2014). There was an increasing trend of OASIS in attempted spontaneous vaginal delivery without episiotorny (P 〈 0.01)~ but it did not increase the OASIS risk (P = 0.46). Univariate analysis of 49 cases and 438 control subjects showed that forceps delivery (odds ratio [OR] -8.73, P 〈 0.01 ), prolong second stage of labor (OR = 1.43, P 〈 0.01) increased the risk lbr OASIS. In multivariate regression models, only lbrceps delivery (OR = 6.28, P 〈 0.01) proved to be independent risk factor. Conclusions: The incidence of OASIS in Chinese women was increased alter 2012, but still lower than the reported figures in the literature. Outlet forceps delivery could be a possible associated risk factor. 展开更多
关键词 Anal Incontinence: Operative Vaginal Delivery Postnatal Care
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Endoscopic ultrasonographic appearance of gastric emphysema 被引量:1
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作者 Maw-Soan Soon Hsu-Heng Yen +2 位作者 anny Soon Otto S Lin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第11期1719-1721,共3页
Emphysematous gastritis (or phlegmonous gastritis) and gastric emphysema (or gastric pneumatosis) are variations of conditions associated with the presence of intramural air in the stomach. The presence of air in the ... Emphysematous gastritis (or phlegmonous gastritis) and gastric emphysema (or gastric pneumatosis) are variations of conditions associated with the presence of intramural air in the stomach. The presence of air in the gastric wall is a very rare clinical condition, associated with bacterial infection, increased intragastric pressure from gastric outlet obstruction, gastric mucosal disruption or air dissection from the mediastinum. In adults, this can occur in the setting of instrumentation-related injury, gastric outlet obstruction by gastric, duodenal or pancreatic malignancies or bowel ischemia. Here we describe a case of gastric emphysema related to repeated biliary stenting and partial duodenal obstruction in a patient with inoperable periampullary cancer, and provide the first description of the endoscopic ultrasonographic findings of gastric emphysema in the literature. In our case, endoscopic ultrasound showed a band of bright echogenicity arising from the submucosa layer, representing air in the gastric wall. 展开更多
关键词 Endoscopic ultrasound Gastric emphysema Gastric pneumatosis
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Management of Cervical Intra Epithelial Neoplasia by Loop Electrosurgical Excision Procedure in a Low Resource Country: An Experience from the YaoundéGeneral Hospital, Cameroon 被引量:1
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作者 Jean Dupont Kemfang Ngowa anny Ngassam +4 位作者 Jovanny Fouogue Tsuala Juny Metogo Zacharie Sando Angèle Kabeyene Jean Marie Kasia 《Open Journal of Obstetrics and Gynecology》 2015年第9期481-486,共6页
Background: Cervical cancer is the third most common cancer worldwide, and 80% of cases occur in the developing world. A critical component of effective cervical cancer screening programs is the ability to offer women... Background: Cervical cancer is the third most common cancer worldwide, and 80% of cases occur in the developing world. A critical component of effective cervical cancer screening programs is the ability to offer women appropriate and effective treatment for cervical intra epithelial neoplasia (CIN). Objectives: This study aimed at assessing the primary experience of management of CIN by Loop Electrosurgical Excision Procedure (LEEP) in a low resource country. Methods: We carried out a descriptive cross sectional study at the Yaoundé General Hospital in Cameroon. Results: Twenty three cases of CIN were treated by LEEP. Mean age of patients was 40.5 ± 9.9 years. Six (26.1%) patients were infected by the Human Immunodeficiency Virus (HIV). LEEP was indicated in 21 (91.30%) cases for CIN2 and CIN3. The mean duration of the surgical procedure was 10 ± 3 minutes. There was one (4.3%) complication (persistent cervical bleeding). Surgical margins were negative for dysplasia or invasive carcinoma in 18 (78.26%) cases and non-applicable in 5 (21.73%) cases (thermal artefacts of margins and cervicitis without CIN). One patient with micro invasive carcinoma on post-operative histology was treated by total hysterectomy. Cervical cytology was normal at 6 months post LEEP for 15 cases out of 16 (93.8%) patients who performed the test. One woman achieved pregnancy and delivered a term baby. Conclusion: Treatment of CIN by LEEP is feasible, safe and effective in our setting. 展开更多
关键词 CERVICAL CANCER CERVICAL Intraepithelial NEOPLASIA LEEP Screening CERVICAL CANCER LOW RESOURCE COUNTRY
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瑞士“农家乐”——瑞士乡村见闻之二 被引量:1
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作者 anny 《农家之友》 2012年第8期60-61,共2页
为了让全世界的旅游者更好地体验瑞士的乡村生活,瑞士有250个农庄设立了农庄旅舍.并且成立了联盟,汉尼先生的农庄就是联盟中的一员。
关键词 瑞士 乡村 农家乐 旅游者 联盟
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HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin 被引量:1
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作者 Yalena Amador-Caizares Gillian Martínez-Donato +16 位作者 Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera 《World Journal of Gastroenterology》 SCIE CAS 2014年第1期148-162,共15页
AIM: To analyze hepatitis C virus (HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-&#x003b1; (IFN-&#x003b1;) plus ribavirin and CIGB-230.
关键词 Clinical trial DNA vaccine Enzyme-linked immunospot Hepatitis C virus LEUKOPENIA
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以色列“铁穹”保护葡萄园
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作者 anny 周熊 《葡萄酒》 2014年第9期12-15,共4页
7月8日以色列对加沙地带发动“护刃行动”,巴勒斯坦和以色列展开新一轮冲突,双方再燃战火。近一个月战事致巴方至少1766人死亡、约9500人受伤,其中大多数为平民。以方也有60多人丧生。在此期间,以色列方面连续轰炸加沙地带,而巴勒... 7月8日以色列对加沙地带发动“护刃行动”,巴勒斯坦和以色列展开新一轮冲突,双方再燃战火。近一个月战事致巴方至少1766人死亡、约9500人受伤,其中大多数为平民。以方也有60多人丧生。在此期间,以色列方面连续轰炸加沙地带,而巴勒斯坦伊斯兰抵抗运动(哈马斯)向以色列发射了上千枚土制火箭弹,其中许多被以色列的“铁穹”系统拦截,但以色列也因此消耗了大量拦截导弹。 展开更多
关键词 以色列 巴勒斯坦伊斯兰抵抗运动 葡萄园 保护 加沙地带 拦截导弹 火箭弹
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健康新视野——治愈癌症的几率取决于你生活的地方?
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作者 anny 《疯狂英语(口语版)》 2015年第4期8-10,共3页
癌症,多么冰冷残酷的字眼,我想大家都会“谈癌色变”。然而我们又是否知道,在世界上不同的地方,癌症的存活率有着巨大的差别。在非洲一些贫困而落后的国家,因为医疗设备供应不足、医生、药物的匮乏,癌症的存活率很低。很多人一旦... 癌症,多么冰冷残酷的字眼,我想大家都会“谈癌色变”。然而我们又是否知道,在世界上不同的地方,癌症的存活率有着巨大的差别。在非洲一些贫困而落后的国家,因为医疗设备供应不足、医生、药物的匮乏,癌症的存活率很低。很多人一旦患上了癌症,就等于拿到了一张死亡判决书。 展开更多
关键词 癌症 生活 几率 治愈 健康 设备供应 存活率 判决书
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母女情深——妈妈的喜剧人生
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作者 anny 《疯狂英语(口语版)》 2015年第4期11-16,共6页
记得小时候,我特别喜欢学妈妈的打扮,学妈妈走路说话时的样子。妈妈的化妆盒,是我儿时经常捧在手里的玩物……长大后,我才渐渐知道,儿时对妈妈的模仿是我们母女问爱的表现。正如本期《无限播客》的班福德母女,女儿把妈妈的言行在... 记得小时候,我特别喜欢学妈妈的打扮,学妈妈走路说话时的样子。妈妈的化妆盒,是我儿时经常捧在手里的玩物……长大后,我才渐渐知道,儿时对妈妈的模仿是我们母女问爱的表现。正如本期《无限播客》的班福德母女,女儿把妈妈的言行在喜剧舞台上展现出来,博得观众一笑的同时,也让我们在欢乐中感受到了什么叫母女情长。 展开更多
关键词 妈妈 喜剧 人生 言行 女儿 欢乐
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职场情商是硬伤?
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作者 Joshua Ogden-Davis 肝脑涂地 anny 《疯狂英语(口语版)》 2014年第10期40-42,共3页
在竞争日渐激烈的求职市场,求职者们都使尽浑身解数,想通过自己的聪明才智、专业技能得到HR的青睐。但是,要想在求职中脱颖而出,我们除了要有IQ这一硬件,还得有软件——职场EQ。职场EQ是指一个人掌控自己和他人情绪的能力在职场和... 在竞争日渐激烈的求职市场,求职者们都使尽浑身解数,想通过自己的聪明才智、专业技能得到HR的青睐。但是,要想在求职中脱颖而出,我们除了要有IQ这一硬件,还得有软件——职场EQ。职场EQ是指一个人掌控自己和他人情绪的能力在职场和工作中的具体表现,更加侧重对自己和他人的工作情绪的了解和把握, 展开更多
关键词 职场 情商 工作情绪 求职市场 专业技能 求职者 EQ 他人
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橱窗求职
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作者 Joshua Odgen-Davis 肝脑涂地 anny 《疯狂英语(口语版)》 2014年第10期43-45,共3页
“蜂蜜”们,你们听过“橱窗求职”吗?这是近年来丹麦一家营销公司推出的一种很有意思的求职方式——把求职者放在店面的橱窗展示。亚历山大·皮特尔斯是“信誉哥本哈根公司”的总经理,他想出了用自己公司的办公室作为开展活动店... “蜂蜜”们,你们听过“橱窗求职”吗?这是近年来丹麦一家营销公司推出的一种很有意思的求职方式——把求职者放在店面的橱窗展示。亚历山大·皮特尔斯是“信誉哥本哈根公司”的总经理,他想出了用自己公司的办公室作为开展活动店面的主意,因为附近有许多企业可能对展出的人才有兴趣。于是,他支起了一个小桌子, 展开更多
关键词 求职者 橱窗 营销公司 求职方式 哥本哈根 亚历山大 总经理 办公室
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