Laser-metal inert-gas(MIG)hybrid welding-brazing was applied to the butt joint of 6061-T6 aluminum alloy and 304 stainless steel.The microstructure and mechanical properties of the joint were studied.An excellent join...Laser-metal inert-gas(MIG)hybrid welding-brazing was applied to the butt joint of 6061-T6 aluminum alloy and 304 stainless steel.The microstructure and mechanical properties of the joint were studied.An excellent joint-section shape was achieved from good wettability on both sides of the stainless steel.Scanning electron microscopy,energy-dispersive spectroscopy and X-ray diffractometry indicated an intermetallic compound(IMC)layer at the 6061-T6/304 interface.The IMC thickness was controlled to be^2μm,which was attributed to the advantage of the laser-MIG hybrid method.Fe3Al dominated in the IMC layer at the interface between the stainless steel and the back reinforcement.The IMC layer in the remaining regions consisted mainly of Fe4Al13.A thinner IMC layer and better wettability on both sides of the stainless steel were obtained,because of the optimized energy distribution from a combination of a laser beam with a MIG arc.The average tensile strength of the joint with reinforcement using laser-MIG hybrid process was improved to be 174 MPa(60%of the 6061-T6 tensile strength),which was significantly higher than that of the joint by traditional MIG process.展开更多
Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia ind...Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 7展开更多
Background:Hepatic vein tumor thrombus(HVTT)is a significant poor risk factor for survival outcomes in hepatocellular carcinoma(HCC)patients.Currently,the widely used international staging systems for HCC are not refi...Background:Hepatic vein tumor thrombus(HVTT)is a significant poor risk factor for survival outcomes in hepatocellular carcinoma(HCC)patients.Currently,the widely used international staging systems for HCC are not refined enough to evaluate prognosis for these patients.A new classification for macroscopic HVTT was established,aiming to better predict prognosis.Methods:This study included 437 consecutive HCC patients with HVTT who underwent different treatments.Overall survival(OS)and time-dependent receiver operating characteristic(ROC)curve area analysis were used to determine the prognostic capacities of the new classification when compared with the different currently used staging systems.Results:The new HVTT classification was defined as:type I,tumor thrombosis involving hepatic vein(HV),including microvascular invasion;type II,tumor thrombosis involving the retrohepatic segment of inferior vena cava;and type III,tumor thrombosis involving the supradiaphragmatic segment of inferior vena cava.The numbers(percentages)of patients with types I,II,and III HVTT in the new classification were 146(33.4%),143(32.7%),and 148(33.9%),respectively.The 1-,2-,and 3-year OS rates for types I to III HVTT were 79.5%,58.6%,and 29.1%;54.8%,23.3%,and 13.8%;and 24.0%,10.0%,and 2.1%,respectively.The time-dependent-ROC curve area analysis demonstrated that the predicting capacity of the new HVTT classification was significantly better than any other staging systems.Conclusions:A new HVTT classification was established to predict prognosis of HCC patients with HVTT who underwent different treatments.This classification was superior to,and it may serve as a supplement to,the commonly used staging systems.展开更多
Background:The presence of hepatic vein tumor thrombus(HVTT)is a major determinant of survival outcomes in hepatocellular carcinoma(HCC)patients.This study compared survival outcomes between liver resection(LR)and int...Background:The presence of hepatic vein tumor thrombus(HVTT)is a major determinant of survival outcomes in hepatocellular carcinoma(HCC)patients.This study compared survival outcomes between liver resection(LR)and intensity-modulated radiation therapy(IMRT)in HCC patients with HVTT.Methods:Data from patients who underwent LR or IMRT for HCC with HVTT at the Eastern Hepatobiliary Surgery Hospital were retrospectively analyzed.Their survival outcomes were compared before and after propensity score matching(PSM).Results:Three hundred and seven HCC patients with HVTT who underwent either LR(n=140)or IMRT(n=167)were enrolled.PSM matched 82 pairs of patients.The overall survival(OS)and recurrence-free survival(RFS)rates were significantly higher for patients in the LR group than those in the IMRT group.On subgroup analysis,significantly better survival outcomes were obtained after LR than IMRT in patients with peripheral type of HVTT(pHVTT)and major type of HVTT(mHVTT).However,similar survival outcomes were obtained after LR and IMRT when the HVTT had developed into inferior vena cava tumor thrombus(IVCTT).Conclusions:LR resulted in significantly better survival outcomes in HCC patients with HVTT when compared to IMRT.Once the HVTT had developed IVCTT,LR and IMRT resulted in similarly bad survival outcomes.展开更多
In this paper, we introduce several new subclasses of the function class Σ of bi-univalent functions analytic in the open unit disc defined by convolution.Furthermore, we investigate the bounds of the coefficients |a...In this paper, we introduce several new subclasses of the function class Σ of bi-univalent functions analytic in the open unit disc defined by convolution.Furthermore, we investigate the bounds of the coefficients |a2| and |a3| for functions in these new subclasses. The results presented in this paper improve or generalize the recent works of other authors.展开更多
This work aims to improve the thermal performance of a light emitting diode(LED) module by employing a novelly assembled heat pipe heat sink. The heat pipe was embedded into the heat sink by a phase change expansion a...This work aims to improve the thermal performance of a light emitting diode(LED) module by employing a novelly assembled heat pipe heat sink. The heat pipe was embedded into the heat sink by a phase change expansion assembly(PCEA) process, which was developed by both finite element(FE) analysis and experiments. Heat transfer performance and optical performance of the LED modules were experimentally investigated and discussed. Compared to the LED module with a traditionally assembled heat pipe heat sink, the LED module employing the PCEA process exhibits about 20% decrease in the thermal resistance from the MCPCB to the heat pipe. The junction temperature is 4% lower and the luminous flux is 2% higher. The improvement in the thermal and optical performance is important to the high power LED applications.展开更多
The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse li...The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury(RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy(VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume(PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), and alkaline phosphatase(ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from-1.5 to 6%;construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.展开更多
In this study,a standard strain of HSV-1 (strain SM44) was used to investigate the antiviral activity of the recombinant Cyanovirin-N (CV-N) against Herpes simplex virus type 1 (HSV-1) in vitro and in vivo.Cytopathic ...In this study,a standard strain of HSV-1 (strain SM44) was used to investigate the antiviral activity of the recombinant Cyanovirin-N (CV-N) against Herpes simplex virus type 1 (HSV-1) in vitro and in vivo.Cytopathic effect (CPE) and MTT assays were used to evaluate the effect of CV-N on HSV-1 in Vero cells.The number of copies of HSV-DNA was detected by real-time fluorescence quantitative PCR (FQ-PCR).The results showed that CV-N had a low cytotoxicity on Vero cells with a CC50 of 359.03±0.56 μg/mL,and that it could not directly inactivate HSV-1 infectivity.CV-N not only reduced the CPE of HSV-1 when added before or after viral infection,with a 50% inhibitory concentration (IC50) with 2.26 and 30.16μg/mL respectively,but it also decreased the copies of HSV-1 DNA in infected host cells.The encephalitis model for HSV-1 infection was conducted in Kunming mice,and treated with three dosages of CV-N (0.5,5 & 10 mg/kg) which was administered intraperitoneally at 2h,3d,5d,7d post infection.The duration for the appearance of symptoms of encephalitis and the survival days were recorded and brain tissue samples were obtained for pathological examination (HE staining).Compared with the untreated control group,in the 5mg/kg CV-N and 10mg/kg CV-N treated groups,the mice suffered light symptoms and the number of survival days were more than 9d and 14d respectively.HE staining also showed that in 5mg/kg CV-N and 10mg/kg CV-N treated groups,the brain cells did not show visible changes,except for a slight inflammation.Our results demonstrated that CV-N has pronounced antiviral activity against HSV-1 both in vitro and in vivo,and it would be a promising new candidate for anti-HSV therapeutics.展开更多
The aim of this paper is to establish the Fekete-Szego inequality for a subclass of bi-univalent strongly quasi-starlike functions which is defined in the open unit disk. Furthermore, the coefficients a2 and a3 for fu...The aim of this paper is to establish the Fekete-Szego inequality for a subclass of bi-univalent strongly quasi-starlike functions which is defined in the open unit disk. Furthermore, the coefficients a2 and a3 for functions in this new subclass are estimated.展开更多
Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its ...Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its subordination relations,inclusion relations and distortion theorems.The results obtained include the related results of some authors as their special case.展开更多
Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned...Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned crystalline nanostructures are highly desirable for the enhanced performance and novel applications.In this study,the cobalt monosulfide(CoS)nanofibers with uniform shape and good crystallinity were firstly obtained via electrospinning and atmospheric calcination routes under controllable conditions.It was found that the CoS nanofibers exhibited ethanol sensing properties at the optimum working temperature of 200℃,the response was 11.6 toward 100×10^(-6) ethanol gas,and the CoS nanofibersbased sensor exhibits a short response time and recovery time of 5 and 6 s at the optimum temperature,respectively,the result also shows that the sensor has good stability after 50 days,which would be a favorable characteristic as a promising sensor.In addition,the Pauli paramagnetic property of CoS nanofibers was also investigated at room temperature.展开更多
To the Editor:Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide[1,2].Portal vein tumor thrombus(PVTT)has been demonstrated to be a poor prognostic indicator for HCC[3-5].However,effective treatm...To the Editor:Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide[1,2].Portal vein tumor thrombus(PVTT)has been demonstrated to be a poor prognostic indicator for HCC[3-5].However,effective treatment for the condition is still limited.Un-derstanding the insight into the molecular mechanisms behind PVTT development may help to establish a new therapeutic strat-egy.展开更多
In this paper, we introduce certain new subclasses of analytic functions defined by generalized multiplier transformation. By using the differential subordination, we study and investigate various inclusion properties...In this paper, we introduce certain new subclasses of analytic functions defined by generalized multiplier transformation. By using the differential subordination, we study and investigate various inclusion properties of these classes. Also inclusion properties of these classes involving the integral operator are considered.展开更多
By using the hypergeometric function defined by the Dziok-Srivastava operator, a new subclass of meromorphic function is introdued. We obtain Fekete-Szeg? inequalities for the meromorphic function f(z) for which α-(1...By using the hypergeometric function defined by the Dziok-Srivastava operator, a new subclass of meromorphic function is introdued. We obtain Fekete-Szeg? inequalities for the meromorphic function f(z) for which α-(1 + α{1 +z[_lI_mf(z)]′′/[_lI_mf(z)]′}/z[_lI_mf(z)]′/_lI_mf(z))■φ(z)(α ∈ C-{1/2, 1}).展开更多
Quantum dots(QDs) can achieve high quantum yields close to unity in liquid solutions, whereas they exhibit a decreased conversion efficiency after being integrated into solid-state polymer matrices for light-emitting ...Quantum dots(QDs) can achieve high quantum yields close to unity in liquid solutions, whereas they exhibit a decreased conversion efficiency after being integrated into solid-state polymer matrices for light-emitting diode(LED) devices, which is called the host matrix effect. In this study, we propose a solid–liquid hybrid-state QD-LED to solve this issue. The ethylene-terminated polydimethylsiloxane (ethylene-PDMS) is used to establish a solid-state cross-linked network, whereas the methyl-terminated PDMS (methyl-PDMS) is used in its liquid state. From a macroscopic level, the cured solid–liquid hybrid-state PDMS (SLHP) composites reach a solid state,which is stable and flexible enough to be used in LED devices. Compared with LEDs using conventional QD/solid PDMS composites at equal color conversion efficiency ranging from 40% to 60%, the luminous flux of LEDs with QD/SLHP composites is increased by 13.0% using an optimized methyl-PDMS concentration of 85 wt. %.As a result, high efficiency QD-LEDs using QDs as the only color convertor with luminous efficacy of 89.6 lm/W (0.19 A) were achieved, which show a working stability comparable with that using conventional solid-state structures at a harsh condition. Consequently, the novel approach shows great potential for achieving high efficiency and high stability QD-LEDs, which is also compatible with current structures used in illumination and display applications.展开更多
基金Project(51405398) supported by the National Natural Science Foundation of China
文摘Laser-metal inert-gas(MIG)hybrid welding-brazing was applied to the butt joint of 6061-T6 aluminum alloy and 304 stainless steel.The microstructure and mechanical properties of the joint were studied.An excellent joint-section shape was achieved from good wettability on both sides of the stainless steel.Scanning electron microscopy,energy-dispersive spectroscopy and X-ray diffractometry indicated an intermetallic compound(IMC)layer at the 6061-T6/304 interface.The IMC thickness was controlled to be^2μm,which was attributed to the advantage of the laser-MIG hybrid method.Fe3Al dominated in the IMC layer at the interface between the stainless steel and the back reinforcement.The IMC layer in the remaining regions consisted mainly of Fe4Al13.A thinner IMC layer and better wettability on both sides of the stainless steel were obtained,because of the optimized energy distribution from a combination of a laser beam with a MIG arc.The average tensile strength of the joint with reinforcement using laser-MIG hybrid process was improved to be 174 MPa(60%of the 6061-T6 tensile strength),which was significantly higher than that of the joint by traditional MIG process.
基金supported by the Major Project for Equipment Development of PLA in 2013(ASY135001)the National High Technology Research and Development Program of China(2015AA020312)
文摘Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 7
基金This work was supported by the Key Project of Natural Science Foundation of China(No.81730097)grants from the Science Fund for Creative Research Groups(No.81521091)+3 种基金the Chang Jiang Scholars Programme[2013]of China Ministry of Educationthe National Key Basic Research Programme“973 Project”(No.2015CB554000)the National Natural Science Foundation of China(No.81602523),the Shanghai Municipal Health Bureau(No.SHDC12015106)the Shanghai Science and Technology Committee(No.134119a0200).
文摘Background:Hepatic vein tumor thrombus(HVTT)is a significant poor risk factor for survival outcomes in hepatocellular carcinoma(HCC)patients.Currently,the widely used international staging systems for HCC are not refined enough to evaluate prognosis for these patients.A new classification for macroscopic HVTT was established,aiming to better predict prognosis.Methods:This study included 437 consecutive HCC patients with HVTT who underwent different treatments.Overall survival(OS)and time-dependent receiver operating characteristic(ROC)curve area analysis were used to determine the prognostic capacities of the new classification when compared with the different currently used staging systems.Results:The new HVTT classification was defined as:type I,tumor thrombosis involving hepatic vein(HV),including microvascular invasion;type II,tumor thrombosis involving the retrohepatic segment of inferior vena cava;and type III,tumor thrombosis involving the supradiaphragmatic segment of inferior vena cava.The numbers(percentages)of patients with types I,II,and III HVTT in the new classification were 146(33.4%),143(32.7%),and 148(33.9%),respectively.The 1-,2-,and 3-year OS rates for types I to III HVTT were 79.5%,58.6%,and 29.1%;54.8%,23.3%,and 13.8%;and 24.0%,10.0%,and 2.1%,respectively.The time-dependent-ROC curve area analysis demonstrated that the predicting capacity of the new HVTT classification was significantly better than any other staging systems.Conclusions:A new HVTT classification was established to predict prognosis of HCC patients with HVTT who underwent different treatments.This classification was superior to,and it may serve as a supplement to,the commonly used staging systems.
基金This work was supported by the Key Project of the Natural Science Foundation of China(No.81730097)grants of the Science Fund for Creative Research Groups(No.81521091)+1 种基金the National Key Basic Research Program“973 Project”(No.2015CB554000)the National Natural Science Foundation of China(No.81602523 and No.81702335).
文摘Background:The presence of hepatic vein tumor thrombus(HVTT)is a major determinant of survival outcomes in hepatocellular carcinoma(HCC)patients.This study compared survival outcomes between liver resection(LR)and intensity-modulated radiation therapy(IMRT)in HCC patients with HVTT.Methods:Data from patients who underwent LR or IMRT for HCC with HVTT at the Eastern Hepatobiliary Surgery Hospital were retrospectively analyzed.Their survival outcomes were compared before and after propensity score matching(PSM).Results:Three hundred and seven HCC patients with HVTT who underwent either LR(n=140)or IMRT(n=167)were enrolled.PSM matched 82 pairs of patients.The overall survival(OS)and recurrence-free survival(RFS)rates were significantly higher for patients in the LR group than those in the IMRT group.On subgroup analysis,significantly better survival outcomes were obtained after LR than IMRT in patients with peripheral type of HVTT(pHVTT)and major type of HVTT(mHVTT).However,similar survival outcomes were obtained after LR and IMRT when the HVTT had developed into inferior vena cava tumor thrombus(IVCTT).Conclusions:LR resulted in significantly better survival outcomes in HCC patients with HVTT when compared to IMRT.Once the HVTT had developed IVCTT,LR and IMRT resulted in similarly bad survival outcomes.
基金The NSF(KJ2015A372) of Anhui Provincial Department of Education
文摘In this paper, we introduce several new subclasses of the function class Σ of bi-univalent functions analytic in the open unit disc defined by convolution.Furthermore, we investigate the bounds of the coefficients |a2| and |a3| for functions in these new subclasses. The results presented in this paper improve or generalize the recent works of other authors.
基金Projects(51375177,U1401249,51405161)supported by the National Natural Science Foundation of ChinaProject(2014M560659)supported by the Postdoctoral Science Foundation of ChinaProject(2014B090901065)supported by the Science and Technology Planning Project for Industry-University-Research Cooperation in Guangdong Province,China
文摘This work aims to improve the thermal performance of a light emitting diode(LED) module by employing a novelly assembled heat pipe heat sink. The heat pipe was embedded into the heat sink by a phase change expansion assembly(PCEA) process, which was developed by both finite element(FE) analysis and experiments. Heat transfer performance and optical performance of the LED modules were experimentally investigated and discussed. Compared to the LED module with a traditionally assembled heat pipe heat sink, the LED module employing the PCEA process exhibits about 20% decrease in the thermal resistance from the MCPCB to the heat pipe. The junction temperature is 4% lower and the luminous flux is 2% higher. The improvement in the thermal and optical performance is important to the high power LED applications.
基金supported by the Natural Science Foundation of Anhui Province (No.2208085MA13)Wu Je Ping Medical Foundation (No.320.6750.2020-10-40)the Key Research and Development Program of Anhui Province (No.202004J07020052)。
文摘The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury(RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy(VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume(PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), and alkaline phosphatase(ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from-1.5 to 6%;construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.
基金Science and Technology Development Project of Shandong province (2005GG3202068)
文摘In this study,a standard strain of HSV-1 (strain SM44) was used to investigate the antiviral activity of the recombinant Cyanovirin-N (CV-N) against Herpes simplex virus type 1 (HSV-1) in vitro and in vivo.Cytopathic effect (CPE) and MTT assays were used to evaluate the effect of CV-N on HSV-1 in Vero cells.The number of copies of HSV-DNA was detected by real-time fluorescence quantitative PCR (FQ-PCR).The results showed that CV-N had a low cytotoxicity on Vero cells with a CC50 of 359.03±0.56 μg/mL,and that it could not directly inactivate HSV-1 infectivity.CV-N not only reduced the CPE of HSV-1 when added before or after viral infection,with a 50% inhibitory concentration (IC50) with 2.26 and 30.16μg/mL respectively,but it also decreased the copies of HSV-1 DNA in infected host cells.The encephalitis model for HSV-1 infection was conducted in Kunming mice,and treated with three dosages of CV-N (0.5,5 & 10 mg/kg) which was administered intraperitoneally at 2h,3d,5d,7d post infection.The duration for the appearance of symptoms of encephalitis and the survival days were recorded and brain tissue samples were obtained for pathological examination (HE staining).Compared with the untreated control group,in the 5mg/kg CV-N and 10mg/kg CV-N treated groups,the mice suffered light symptoms and the number of survival days were more than 9d and 14d respectively.HE staining also showed that in 5mg/kg CV-N and 10mg/kg CV-N treated groups,the brain cells did not show visible changes,except for a slight inflammation.Our results demonstrated that CV-N has pronounced antiviral activity against HSV-1 both in vitro and in vivo,and it would be a promising new candidate for anti-HSV therapeutics.
基金The NSF(KJ2018A0833)of Anhui Provincial Department of Educationthe Scientific Research Foundation(17X0413)of Guangzhou Civil Aviation College
文摘The aim of this paper is to establish the Fekete-Szego inequality for a subclass of bi-univalent strongly quasi-starlike functions which is defined in the open unit disk. Furthermore, the coefficients a2 and a3 for functions in this new subclass are estimated.
基金Supported by the Doctoral Foundation of the Education Committee of China(20050574002)
文摘Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its subordination relations,inclusion relations and distortion theorems.The results obtained include the related results of some authors as their special case.
基金financially supported by the National Natural Science Foundation of China(No.51227804)the Postdoctoral Scientific Research Foundation of Qingdao and National College Students Innovation and Entrepreneurship Training Program of China(No.G201911065028)College Students Innovation and Entrepreneurship Training Program of Qingdao University(No.X202011065055)。
文摘Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned crystalline nanostructures are highly desirable for the enhanced performance and novel applications.In this study,the cobalt monosulfide(CoS)nanofibers with uniform shape and good crystallinity were firstly obtained via electrospinning and atmospheric calcination routes under controllable conditions.It was found that the CoS nanofibers exhibited ethanol sensing properties at the optimum working temperature of 200℃,the response was 11.6 toward 100×10^(-6) ethanol gas,and the CoS nanofibersbased sensor exhibits a short response time and recovery time of 5 and 6 s at the optimum temperature,respectively,the result also shows that the sensor has good stability after 50 days,which would be a favorable characteristic as a promising sensor.In addition,the Pauli paramagnetic property of CoS nanofibers was also investigated at room temperature.
文摘To the Editor:Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide[1,2].Portal vein tumor thrombus(PVTT)has been demonstrated to be a poor prognostic indicator for HCC[3-5].However,effective treatment for the condition is still limited.Un-derstanding the insight into the molecular mechanisms behind PVTT development may help to establish a new therapeutic strat-egy.
基金Foundation item： Supported by the Natural Science Foundation of Department of Education of Anhui Province（KJ2012Z300）
文摘In this paper, we introduce certain new subclasses of analytic functions defined by generalized multiplier transformation. By using the differential subordination, we study and investigate various inclusion properties of these classes. Also inclusion properties of these classes involving the integral operator are considered.
基金The NSF(KJ2015A372)of Anhui Provincial Department of Education
文摘By using the hypergeometric function defined by the Dziok-Srivastava operator, a new subclass of meromorphic function is introdued. We obtain Fekete-Szeg? inequalities for the meromorphic function f(z) for which α-(1 + α{1 +z[_lI_mf(z)]′′/[_lI_mf(z)]′}/z[_lI_mf(z)]′/_lI_mf(z))■φ(z)(α ∈ C-{1/2, 1}).
基金National Natural Science Foundation of China(NSFC)(51735004,51775199)Natural Science Foundation of Guangdong Province(2014A030312017)Science Technology Program of Guangdong Province(2016B010130001)
文摘Quantum dots(QDs) can achieve high quantum yields close to unity in liquid solutions, whereas they exhibit a decreased conversion efficiency after being integrated into solid-state polymer matrices for light-emitting diode(LED) devices, which is called the host matrix effect. In this study, we propose a solid–liquid hybrid-state QD-LED to solve this issue. The ethylene-terminated polydimethylsiloxane (ethylene-PDMS) is used to establish a solid-state cross-linked network, whereas the methyl-terminated PDMS (methyl-PDMS) is used in its liquid state. From a macroscopic level, the cured solid–liquid hybrid-state PDMS (SLHP) composites reach a solid state,which is stable and flexible enough to be used in LED devices. Compared with LEDs using conventional QD/solid PDMS composites at equal color conversion efficiency ranging from 40% to 60%, the luminous flux of LEDs with QD/SLHP composites is increased by 13.0% using an optimized methyl-PDMS concentration of 85 wt. %.As a result, high efficiency QD-LEDs using QDs as the only color convertor with luminous efficacy of 89.6 lm/W (0.19 A) were achieved, which show a working stability comparable with that using conventional solid-state structures at a harsh condition. Consequently, the novel approach shows great potential for achieving high efficiency and high stability QD-LEDs, which is also compatible with current structures used in illumination and display applications.
