Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study a...Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/BCR-seq.EBV(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.展开更多
基金This work was supported by National Natural Science Foundation of China(81930065,82173128 to R-H.X.,82073377,81772587 to M.Z.Q.,82172861 to Q.Z.)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-12M-5-036,to R.-H.X.)+2 种基金Natural Science Foundation of Guangdong(2021A1515012439 to M.Z.Q.2021A1515011743 to Q.Z.)Opening Fund of Guangdong Provincial Key Laboratory of Biomedical Imaging(No.GPKLBI202108 of 2018B030322006 to H.Y.Z.)Ministry of Education Frontiers Science Centre for Precision Oncology,University of Macao(SP2023-00001-FSCPO to H.Y.Z.).
文摘Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/BCR-seq.EBV(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.
