In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep a...In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography （PSG） were performed on days 14 and 90 post-stroke. Compared to heal- thy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cog- nitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.展开更多
The sediments in the foreland basins around the Qinghai-Tibetan Plateau preserved crucial information to reveal its tectonic history. In the Hexi Corridor, north periphery of the Qinghai-Tibetan Plateau, the angular u...The sediments in the foreland basins around the Qinghai-Tibetan Plateau preserved crucial information to reveal its tectonic history. In the Hexi Corridor, north periphery of the Qinghai-Tibetan Plateau, the angular unconformity between the Jiuquan Gravel and the Yumen Conglomerate has been well known to represent an intensive tectonic event of the plateau. However, its age is poorly constrained. Our paleomagnetic dating at the Laojunmiao section in the Jiuxi Basin show that the bottom of the Jiuquan Gravel reaches 0.84 MaBP, the top of the Yumen Conglomerate is about 0.93 MaBP. This result clearly demonstrates that the northern Qinghai-Tibetan Plateau experienced an intensive movement at mid-Pleistocene.展开更多
To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of th...To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.展开更多
风电变流器(wind power converter,WPC)是风电转换系统的关键部件,承担着风机功率变换和并网的重要功能。WPC故障会造成整个风电机组停运,其可靠性高低对风电转换系统乃至整个风电场的可靠性都有较大影响。由于海上风电场运行环境恶劣,...风电变流器(wind power converter,WPC)是风电转换系统的关键部件,承担着风机功率变换和并网的重要功能。WPC故障会造成整个风电机组停运,其可靠性高低对风电转换系统乃至整个风电场的可靠性都有较大影响。由于海上风电场运行环境恶劣,故障元件的维修与更换困难,WPC对海上风电场整体可靠性的影响也更为严重。基于WPC的故障机理,建立了计及WPC故障的海上风电场风电转换系统可靠性模型。基于该模型,进一步考虑风机尾流效应和风电场集电系统的故障,对海上风电场进行了可靠性评估,研究了WPC故障对海上风电场整体可靠性的影响,并对影响变流器和海上风电场可靠性的主要因素进行了灵敏度分析。算例结果表明,风电机组变流器故障对海上风电场整体可靠性的影响较大,在计及变流器故障的影响后,海上风电场的容量因子将显著降低。展开更多
Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of env...Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of environmental friendliness, mechanical properties, and stability. Here, we report a super-strong, biodegradable, and washable cellulose-based conductive macrofibers, which is prepared by wet-stretching and wet-twisting bacterial cellulose hydrogel incorporated with carbon nanotubes and polypyrrole. The cellulose-based conductive macrofibers possess high tensile strength of 449 MPa(able to lift 2 kg weights), good electrical conductivity(~ 5.32 S cm^(-1)), and excellent stability(Tensile strength and conductivity only decrease by 6.7% and 8.1% after immersing in water for 1 day). The degradation experiment demonstrates macrofibers can be degraded within 108 h in the cellulase solution. The designed fabric-based TENG from the cellulose-base conductive macrofibers shows a maximum open-circuit voltage of 170 V, short-circuit current of 0.8 μA, and output power at 352 μW, which is capable of powering the commercial electronics by charging the capacitors. More importantly, the fabric-based TENGs can be attached to the human body and work as self-powered sensors to effectively monitor human motions. This study suggests the potential of biodegradable, super-strong, and washable conductive cellulose-based fiber for designing eco-friendly fabric-based TENG for energy harvesting and biomechanical monitoring.展开更多
The complete 15,831 bp nucleotide sequence of the mitochondrial genome from Elimaea cheni （Phaneropterinae） was determined. The putative initiation codon for cox1 was TTA. The phylogeny of Orthoptera based on differ...The complete 15,831 bp nucleotide sequence of the mitochondrial genome from Elimaea cheni （Phaneropterinae） was determined. The putative initiation codon for cox1 was TTA. The phylogeny of Orthoptera based on different mtDNA datasets were analyzed with maximum likelihood （ML） and Bayesian inference （BI）. When all 37 genes （mtDNA） were analyzed simultaneously, the monophyly of Caelifera and Ensifera were recovered in the context of our taxon sampling. The phylogeny of Orthoptera was largely consistent with previous phylogenetic hypotheses. Rhaphidophoridae to be a sister group of Tettigoniidae, and the relationships among four subfamilies of Tettigoniidae were （Phaneropterinae ＋ （Conocephalinae ＋ （Bradyporinae ＋ Tettigoniinae）））. Pyrgomorphidae was the most basal group of Caelifera. The relationships among six acridid subfamilies were （Oedipodinae ＋ （Acridinae ＋ （Gomphocerinae ＋ （Oxyinae ＋ （Callip- taminae ＋ Cyrtacanthacridinae）））））. However, we did not recover a monophyletic Grylloidea. Myrmecophilidae clustered into one clade with Gryllotalpidae instead of with Gryllidae. ML and BI analyses of all protein coding genes （using all nucleotide sequence data or excluding the third codon position, and amino acid sequences） revealed a topology identical to that of the entire mtDNA genome dataset. However, 22 tRNAs genes excluding the DHU loop and TψC loop （TRNA）, and two rRNA genes （RRNA） perform poorly when analyzed as single dataset. Our results suggest that the best phylogenetic inferences were ML and BI methods based on total mtDNA. Excluding tRNA genes, rRNA genes and the third codon position of protein coding genes from dataset and converting nucleotide sequences to amino acid sequences do not positively affect phylogenetic reconstruction.展开更多
基金supported by the Health Industry Key Research Project of Tianjin Municipality,China(12KG132)the Science and Technology Plan Project of Tianjin Municipality,China(13ZCZDSY01900)
文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography （PSG） were performed on days 14 and 90 post-stroke. Compared to heal- thy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cog- nitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.
基金This work was co-supported by the National Key Basic Research Project (Grant No. G1998040809)the National Natural Science Foundation of China (Grant No. 49731010).
文摘The sediments in the foreland basins around the Qinghai-Tibetan Plateau preserved crucial information to reveal its tectonic history. In the Hexi Corridor, north periphery of the Qinghai-Tibetan Plateau, the angular unconformity between the Jiuquan Gravel and the Yumen Conglomerate has been well known to represent an intensive tectonic event of the plateau. However, its age is poorly constrained. Our paleomagnetic dating at the Laojunmiao section in the Jiuxi Basin show that the bottom of the Jiuquan Gravel reaches 0.84 MaBP, the top of the Yumen Conglomerate is about 0.93 MaBP. This result clearly demonstrates that the northern Qinghai-Tibetan Plateau experienced an intensive movement at mid-Pleistocene.
基金supported by grants from the National Key Research and Development Program of China(2016YFC1306700 to ZJZ,2016YFC1306704 to HXZ)the National Natural Science Key Foundation of China(81830040 to ZJZ)+2 种基金Science and Technology Program of Guangdong(2018B030334001 to ZJZ)Program of Excellent Talents in Medical Science of Jiangsu Province(JCRCA2016006 to ZJZ)the Program for Innovative Research Team in Science and Technology in University of Henan Province(18IRTSTHN025 to HXZ)。
文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.
文摘风电变流器(wind power converter,WPC)是风电转换系统的关键部件,承担着风机功率变换和并网的重要功能。WPC故障会造成整个风电机组停运,其可靠性高低对风电转换系统乃至整个风电场的可靠性都有较大影响。由于海上风电场运行环境恶劣,故障元件的维修与更换困难,WPC对海上风电场整体可靠性的影响也更为严重。基于WPC的故障机理,建立了计及WPC故障的海上风电场风电转换系统可靠性模型。基于该模型,进一步考虑风机尾流效应和风电场集电系统的故障,对海上风电场进行了可靠性评估,研究了WPC故障对海上风电场整体可靠性的影响,并对影响变流器和海上风电场可靠性的主要因素进行了灵敏度分析。算例结果表明,风电机组变流器故障对海上风电场整体可靠性的影响较大,在计及变流器故障的影响后,海上风电场的容量因子将显著降低。
基金financially supported by BRICS STI Framework Programme 3rd call 2019the National Key Research and Development Program of China(Grant No.2018YFE0123700)+3 种基金the National Natural Science Foundation of China(Grant Nos.51973076 and 52073031)State Key Laboratory of New Textile Materials and Advanced Processing Technologies(Grant No.FZ2021005)the Fundamental Research Funds for the Central Universities(Grant Nos.2020kfyXJJS035,WUT2018IVB006,and Z191100001119047)。
文摘Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of environmental friendliness, mechanical properties, and stability. Here, we report a super-strong, biodegradable, and washable cellulose-based conductive macrofibers, which is prepared by wet-stretching and wet-twisting bacterial cellulose hydrogel incorporated with carbon nanotubes and polypyrrole. The cellulose-based conductive macrofibers possess high tensile strength of 449 MPa(able to lift 2 kg weights), good electrical conductivity(~ 5.32 S cm^(-1)), and excellent stability(Tensile strength and conductivity only decrease by 6.7% and 8.1% after immersing in water for 1 day). The degradation experiment demonstrates macrofibers can be degraded within 108 h in the cellulase solution. The designed fabric-based TENG from the cellulose-base conductive macrofibers shows a maximum open-circuit voltage of 170 V, short-circuit current of 0.8 μA, and output power at 352 μW, which is capable of powering the commercial electronics by charging the capacitors. More importantly, the fabric-based TENGs can be attached to the human body and work as self-powered sensors to effectively monitor human motions. This study suggests the potential of biodegradable, super-strong, and washable conductive cellulose-based fiber for designing eco-friendly fabric-based TENG for energy harvesting and biomechanical monitoring.
基金supported by the National Natural Science Foundation of China(No.30670279 and 30670252)Talent Foundation of Hebei University(No.2008-138)
文摘The complete 15,831 bp nucleotide sequence of the mitochondrial genome from Elimaea cheni （Phaneropterinae） was determined. The putative initiation codon for cox1 was TTA. The phylogeny of Orthoptera based on different mtDNA datasets were analyzed with maximum likelihood （ML） and Bayesian inference （BI）. When all 37 genes （mtDNA） were analyzed simultaneously, the monophyly of Caelifera and Ensifera were recovered in the context of our taxon sampling. The phylogeny of Orthoptera was largely consistent with previous phylogenetic hypotheses. Rhaphidophoridae to be a sister group of Tettigoniidae, and the relationships among four subfamilies of Tettigoniidae were （Phaneropterinae ＋ （Conocephalinae ＋ （Bradyporinae ＋ Tettigoniinae）））. Pyrgomorphidae was the most basal group of Caelifera. The relationships among six acridid subfamilies were （Oedipodinae ＋ （Acridinae ＋ （Gomphocerinae ＋ （Oxyinae ＋ （Callip- taminae ＋ Cyrtacanthacridinae）））））. However, we did not recover a monophyletic Grylloidea. Myrmecophilidae clustered into one clade with Gryllotalpidae instead of with Gryllidae. ML and BI analyses of all protein coding genes （using all nucleotide sequence data or excluding the third codon position, and amino acid sequences） revealed a topology identical to that of the entire mtDNA genome dataset. However, 22 tRNAs genes excluding the DHU loop and TψC loop （TRNA）, and two rRNA genes （RRNA） perform poorly when analyzed as single dataset. Our results suggest that the best phylogenetic inferences were ML and BI methods based on total mtDNA. Excluding tRNA genes, rRNA genes and the third codon position of protein coding genes from dataset and converting nucleotide sequences to amino acid sequences do not positively affect phylogenetic reconstruction.
