Lumbar disc herniation is a common disease in the clinical context and does great harm to either the physical or mental health of patients suffering from this disease.Many guidelines and consensus for the diagnosis an...Lumbar disc herniation is a common disease in the clinical context and does great harm to either the physical or mental health of patients suffering from this disease.Many guidelines and consensus for the diagnosis and treatment of lumbar disc herniation have been published domestically and internationally.According to the expert consensus,clinicians could adopt tailored and personalized diagnosis and treatment management strategies for lumbar disc herniation patients.展开更多
BACKGROUND Liver cancer is a malignant tumor with a high incidence.At present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in ...BACKGROUND Liver cancer is a malignant tumor with a high incidence.At present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in LH,and the most common fluorescent types of tumors are total fluorescence,partial fluorescence,and rim fluorescence.CASE SUMMARY We presented four cases of LH guided by ICG-FI in which we also observed the fourth special fluorescent type.When the tumor or intrahepatic stone compresses the adjacent bile duct to cause local cholestasis,the liver segment or subsegment with obstructed bile drainage will show strong fluorescence.Complete removal of the lesion together with the fluorescent liver parenchyma may help reduce the risk of tumor or stone recurrence.CONCLUSION This type of partial fluorescence can indicate local biliary compression,and the resection method is related to bile drainage,which may be called functional anatomical hepatectomy and ensures radical resection of the lesion.展开更多
Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselect...Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom economy.Computational studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol reaction.Of the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and cycloolivil.Given the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.展开更多
Monogamy and polygamy relations are essential properties of quantum entanglement,which characterize the distributions of entanglement in multipartite systems.In this paper,we establish the general monogamy relations ...Monogamy and polygamy relations are essential properties of quantum entanglement,which characterize the distributions of entanglement in multipartite systems.In this paper,we establish the general monogamy relations forγ-th(0≤γ≤α,α≥1)power of quantum entanglement based on unified-(q,s)entanglement and polygamy relations forδ-th(δ≥β,0≤β≤1)power of entanglement of assistance based on unified-(q,s)entanglement of assistance,which provides a complement to the previous research in terms of different parameter regions ofγandδ.These results are then applied to specific quantum correlations,e.g.,entanglement of formation,Renyi-q entanglement of assistance and Tsallis-q entanglement of assistance to get the corresponding monogamy and polygamy inequalities.Moreover,typical examples are presented for illustration.展开更多
Background Ankylosing spondylitis （AS） is a common inflammatory rheumatic disease which lacks satisfactory treatment so far.Sinomenine （SIN） is an alkaloid and has recently been utilized in treating multiple rheum...Background Ankylosing spondylitis （AS） is a common inflammatory rheumatic disease which lacks satisfactory treatment so far.Sinomenine （SIN） is an alkaloid and has recently been utilized in treating multiple rheumatic diseases including AS in China,but its exact mechanism remains to be explored.This study investigated the alteration of proteome in peripheral blood mononuclear cells （PBMCs） from AS patients.Methods Thirty AS patients were enrolled in this study.PBMCs from each AS patient were cultured in medium with or without SIN respectively.Then PBMCs proteins from both groups were separated by two-dimensional electrophoresis （2-DE） and analyzed by mass spectrometry （MS）.Two differentially expressed proteins were then chosen to be verified using Western blotting.Results Seven proteins,including α-synuclein （SNCA）,calmodulin （CALM）,acidic leucine-rich nuclear phosphoprotein 32 family member A （ANP32A）,chloride intracellular channel protein 1 （CLIC1）,guanine nucleotide-binding protein G（I）/G（S）/ G（T） subunit beta-1 （GNB1）,gelsolin （GSN） and histone H2B type 1-M （HISTH2BM）were over-expressed,while coronin1A （CORO1A） was under-expressed in the SIN-treated PBMCs.Further bioinformatics search indicated that the changes of SNCA,ANP32A and CLIC1 pertained to apoptosis,while changes of GSN and CORO1A were associated with both apoptosis and inhibition of immunological function.Subsequently GSN and CORO1A were selected to validate by Western blotting and the results were consistent with those of 2-DE.Conclusion There were 8 differentially expressed proteins in the SIN-treated PBMCs,which might shed some light on the mechanism of SIN in the treatment of AS.展开更多
为了解决DPOS共识算法(Delegated Proof of Stake,股份授权证明机制)吞吐性能不足的问题,本文提出加权指标动态均衡算法(DPOS with weighted Index Dynamically Balancing,DPOS+IDB).该算法首先利用区块链的通道机制,将带有不同标签的...为了解决DPOS共识算法(Delegated Proof of Stake,股份授权证明机制)吞吐性能不足的问题,本文提出加权指标动态均衡算法(DPOS with weighted Index Dynamically Balancing,DPOS+IDB).该算法首先利用区块链的通道机制,将带有不同标签的交易分配到不同的区块链通道中.然后对每一个区块链通道,分别进程参数配置优化.最终,将参数配置优化问题,转化为对多个指标求解整体最优解问题.通过优化参数配置,提高区块链通道的吞吐性能.由于求解过程中,需要在多个指标可行范围内进搜索,求解空间过大.为此,设计动态均衡搜索算法进行求解,利用求解的结果对区块链网络进行优化配置,提高提高区块链网络的性能.仿真表明,对比原始DPOS算法、CE-DPOS(Comprehensive Election-DPOS,综合选举)算法和RC-DPOS(Reputation Classification-DPOS,名誉分级)算法,DPOS+IDB算法在时延、吞吐率有较好的性能表现,并且通讯开销的复杂度由节点数量的平方降低至节点数量的一次方.展开更多
AIM： To investigate the surgical treatment of patients with intermediate-terminal pancreatic cancer. METHODS： A retrospective analysis was made of the clinical data of 163 patients with intermediate-terminal pancrea...AIM： To investigate the surgical treatment of patients with intermediate-terminal pancreatic cancer. METHODS： A retrospective analysis was made of the clinical data of 163 patients with intermediate-terminal pancreatic cancer who were surgically treated between August 1994 and August 2003. RESULTS： A total of 149 patients underwent palliative surgery. The mortality rate of those who underwent cholecystojejunostomy alone was 14.2%, the icterus or cholangitis recurrence rate was 61.9% with an average survival period of 7.1 too. The mortality rate for those who received hepatic duct-jejunostomy （HDJS） was 5.7%, the icterus or cholangitis recurrence rate was 6.8% with an average survival period of 7.1 too. But 31.8% of the patients developed duodenum obstruction within 6 mo after the surgery, six of seven patients with severe pain were given peri-abdominal aorta injection with absolute alcohol and their pain was alleviated. The other patients underwent percutaneous transhepatic cholangial drainage （PTCD） and their icterus index returned to normal level within 40 d with an average survival period of 7.5 mo. CONCLUSION： Roux-en-y HDJS combined with prophylactic gastrojejunostomy is recommended for patients with intermediate-terminal pancreatic cancer, and biliary prosthesis can partly relieve biliary obstruction in a short term.展开更多
文摘Lumbar disc herniation is a common disease in the clinical context and does great harm to either the physical or mental health of patients suffering from this disease.Many guidelines and consensus for the diagnosis and treatment of lumbar disc herniation have been published domestically and internationally.According to the expert consensus,clinicians could adopt tailored and personalized diagnosis and treatment management strategies for lumbar disc herniation patients.
基金Supported by National Natural Science Foundation of China,No.81972792.
文摘BACKGROUND Liver cancer is a malignant tumor with a high incidence.At present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in LH,and the most common fluorescent types of tumors are total fluorescence,partial fluorescence,and rim fluorescence.CASE SUMMARY We presented four cases of LH guided by ICG-FI in which we also observed the fourth special fluorescent type.When the tumor or intrahepatic stone compresses the adjacent bile duct to cause local cholestasis,the liver segment or subsegment with obstructed bile drainage will show strong fluorescence.Complete removal of the lesion together with the fluorescent liver parenchyma may help reduce the risk of tumor or stone recurrence.CONCLUSION This type of partial fluorescence can indicate local biliary compression,and the resection method is related to bile drainage,which may be called functional anatomical hepatectomy and ensures radical resection of the lesion.
基金supported by the Shanghai Pujiang Program(22PJ1415800)the National Natural Science Foundation of China(22237007,T2192972)+2 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022282)the Laboratory for Molecular Engineering of Chiral Drugs,Shanghai Jiao Tong University(SMECD2022005)the High-Performance Computing Platform of Peking University。
文摘Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom economy.Computational studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol reaction.Of the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and cycloolivil.Given the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.
基金Project supported by the National Natural Science Foundation of China(Grant No.12175147)the Disciplinary Funding of Beijing Technology and Business University,the Fundamental Research Funds for the Central Universities(Grant No.2022JKF02015)the Research and Development Program of Beijing Municipal Education Commission(Grant No.KM202310011012).
文摘Monogamy and polygamy relations are essential properties of quantum entanglement,which characterize the distributions of entanglement in multipartite systems.In this paper,we establish the general monogamy relations forγ-th(0≤γ≤α,α≥1)power of quantum entanglement based on unified-(q,s)entanglement and polygamy relations forδ-th(δ≥β,0≤β≤1)power of entanglement of assistance based on unified-(q,s)entanglement of assistance,which provides a complement to the previous research in terms of different parameter regions ofγandδ.These results are then applied to specific quantum correlations,e.g.,entanglement of formation,Renyi-q entanglement of assistance and Tsallis-q entanglement of assistance to get the corresponding monogamy and polygamy inequalities.Moreover,typical examples are presented for illustration.
基金This work was supported by grants from Guangdong Natural Science Foundation （No. 10151008901000010 and No. $2012010011137） and Guangdong Science and Technology Project （No. 2009B080701034）. Conflict of interest： The authors have no conflicts of interest.
文摘Background Ankylosing spondylitis （AS） is a common inflammatory rheumatic disease which lacks satisfactory treatment so far.Sinomenine （SIN） is an alkaloid and has recently been utilized in treating multiple rheumatic diseases including AS in China,but its exact mechanism remains to be explored.This study investigated the alteration of proteome in peripheral blood mononuclear cells （PBMCs） from AS patients.Methods Thirty AS patients were enrolled in this study.PBMCs from each AS patient were cultured in medium with or without SIN respectively.Then PBMCs proteins from both groups were separated by two-dimensional electrophoresis （2-DE） and analyzed by mass spectrometry （MS）.Two differentially expressed proteins were then chosen to be verified using Western blotting.Results Seven proteins,including α-synuclein （SNCA）,calmodulin （CALM）,acidic leucine-rich nuclear phosphoprotein 32 family member A （ANP32A）,chloride intracellular channel protein 1 （CLIC1）,guanine nucleotide-binding protein G（I）/G（S）/ G（T） subunit beta-1 （GNB1）,gelsolin （GSN） and histone H2B type 1-M （HISTH2BM）were over-expressed,while coronin1A （CORO1A） was under-expressed in the SIN-treated PBMCs.Further bioinformatics search indicated that the changes of SNCA,ANP32A and CLIC1 pertained to apoptosis,while changes of GSN and CORO1A were associated with both apoptosis and inhibition of immunological function.Subsequently GSN and CORO1A were selected to validate by Western blotting and the results were consistent with those of 2-DE.Conclusion There were 8 differentially expressed proteins in the SIN-treated PBMCs,which might shed some light on the mechanism of SIN in the treatment of AS.
文摘为了解决DPOS共识算法(Delegated Proof of Stake,股份授权证明机制)吞吐性能不足的问题,本文提出加权指标动态均衡算法(DPOS with weighted Index Dynamically Balancing,DPOS+IDB).该算法首先利用区块链的通道机制,将带有不同标签的交易分配到不同的区块链通道中.然后对每一个区块链通道,分别进程参数配置优化.最终,将参数配置优化问题,转化为对多个指标求解整体最优解问题.通过优化参数配置,提高区块链通道的吞吐性能.由于求解过程中,需要在多个指标可行范围内进搜索,求解空间过大.为此,设计动态均衡搜索算法进行求解,利用求解的结果对区块链网络进行优化配置,提高提高区块链网络的性能.仿真表明,对比原始DPOS算法、CE-DPOS(Comprehensive Election-DPOS,综合选举)算法和RC-DPOS(Reputation Classification-DPOS,名誉分级)算法,DPOS+IDB算法在时延、吞吐率有较好的性能表现,并且通讯开销的复杂度由节点数量的平方降低至节点数量的一次方.
基金Supported by the Medical Science Technology Foundation of Guangdong Province,No.WSTJJ20021025210102701008182
文摘AIM： To investigate the surgical treatment of patients with intermediate-terminal pancreatic cancer. METHODS： A retrospective analysis was made of the clinical data of 163 patients with intermediate-terminal pancreatic cancer who were surgically treated between August 1994 and August 2003. RESULTS： A total of 149 patients underwent palliative surgery. The mortality rate of those who underwent cholecystojejunostomy alone was 14.2%, the icterus or cholangitis recurrence rate was 61.9% with an average survival period of 7.1 too. The mortality rate for those who received hepatic duct-jejunostomy （HDJS） was 5.7%, the icterus or cholangitis recurrence rate was 6.8% with an average survival period of 7.1 too. But 31.8% of the patients developed duodenum obstruction within 6 mo after the surgery, six of seven patients with severe pain were given peri-abdominal aorta injection with absolute alcohol and their pain was alleviated. The other patients underwent percutaneous transhepatic cholangial drainage （PTCD） and their icterus index returned to normal level within 40 d with an average survival period of 7.5 mo. CONCLUSION： Roux-en-y HDJS combined with prophylactic gastrojejunostomy is recommended for patients with intermediate-terminal pancreatic cancer, and biliary prosthesis can partly relieve biliary obstruction in a short term.
