To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory ...To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics.展开更多
Upconversion based nanothermometry has received much attention due to its merits of stability,narrow band emission and rich emission peaks.However,the previous works are mainly focused on the emissions from thermally ...Upconversion based nanothermometry has received much attention due to its merits of stability,narrow band emission and rich emission peaks.However,the previous works are mainly focused on the emissions from thermally coupled energy levels which is theoretically limited by Boltzmann distribution theory with resultant low temperature sensitivity in particular at ultralow temperatures.Here we report a LiYF_(4):Yb/Ho@LiYF_(4) core-shell nanostructure to improve the sensitivity at low temperatures by taking advantage of non-thermally coupled energy levels of Ho^(3+).In detail,the green upconversion emission of Ho^(3+)shows an increase with reducing temperature while its red upconversion emission presents a decline during the same process.This is primarily due to the suppression of the non-radiative multiphonon relaxation occurred at the green emitting levels(^(5)F_(4),^(5)S_(2)) and the intermediate level(^(5)I_(6)) at low temperatures.Such a feature contributes to a high relative sensitivity of 7.17%/K at 11 K,much higher than reported values.Our results provide a promising candidate for the development of nanothermometer with high-sensitive low-temperature sensing performance.展开更多
In this paper we consider the finite time quenching behavior of solutions to a semilinear heat equation with a nonlinear Neumann boundary condition. Firstly, we establish conditions on nonlinear source and boundary to...In this paper we consider the finite time quenching behavior of solutions to a semilinear heat equation with a nonlinear Neumann boundary condition. Firstly, we establish conditions on nonlinear source and boundary to guarantee that the solution doesn＇t quench for all time. Secondly, we give sufficient conditions on data such that the solution quenches in finite time, and derive an upper bound of quenching time. Thirdly, undermore restrictive conditions, we obtain a lower bound of quenching time. Finally, we give the exact bounds of quenching time of a special example.展开更多
In this paper, Liouville-type theorems of nonnegative solutions for some elliptic integral systems are considered. We use a new type of moving plane method introduced by Chen-Li-Ou. Our new ingredient is the use of St...In this paper, Liouville-type theorems of nonnegative solutions for some elliptic integral systems are considered. We use a new type of moving plane method introduced by Chen-Li-Ou. Our new ingredient is the use of Stein-Weiss inequality instead of Maximum Principle.展开更多
The luminescence in the second near-infrared(NIR-II)spectral region(1,000–1,700 nm)has recently attracted great attention for emerging biological applications owing to its merit of deep tissue bioimaging and high spa...The luminescence in the second near-infrared(NIR-II)spectral region(1,000–1,700 nm)has recently attracted great attention for emerging biological applications owing to its merit of deep tissue bioimaging and high spatiotemporal resolution.However,it still remains a challenge to achieve the highly efficient NIR-II emissions of lanthanides in nanomaterials.Herein,we report an ideal design of sensitizing lithium sublattice core–shell nanocrystals for efficient NIR-II emission properties from a set of lanthanide emitters including Er3+,Tm3+,Ho3+,Pr3+,and Nd3+.In particular,the typical NIR-II emission of Er3+at 1.5μm was greatly enhanced by further manipulating the energy transfer via Er3+–Ce3+cross-relaxation,and the quantum yield can reach up to 35.74%under 980 nm excitation(12.5 W·cm−2),which is the highest value to the best of our knowledge.The 808 nm responsive efficient NIR-II emission was also enabled at the single-particle level through rational core–shell–shell structure design.Moreover,the lithium-sublattice provides an obvious spectral Stark-splitting feature,which can be used in the ultrasensitive NIR-II nanothermometer with relative sensitivity of 0.248%K−1 and excellent thermal cycling stability.These results open a door to the research of new kinds of efficient NIR-II luminescent materials,showing great promise in various frontier fields such as deep tissue nanothermometry and in vivo bioimaging.展开更多
We study the porous medium equation ut=(um). 0<x<∞, t>0 with a singular boundary condition (um) (0,t)=u-β(0,t). We prove finite time quenching for the solution at the boundary χ=0. We also establish the qu...We study the porous medium equation ut=(um). 0<x<∞, t>0 with a singular boundary condition (um) (0,t)=u-β(0,t). We prove finite time quenching for the solution at the boundary χ=0. We also establish the quenching rate and asymptotic behavior on the quenching point.展开更多
In this paper, we study the positive solutions for a class of integral systems and prove that all the solutions are radially symmetric and monotonically decreasing about some point. Moreover, we also obtain the unique...In this paper, we study the positive solutions for a class of integral systems and prove that all the solutions are radially symmetric and monotonically decreasing about some point. Moreover, we also obtain the uniqueness result for a special case. We use a new type of moving plane method introduced by Chen-Li-Ou [1]. Our new ingredient is the use of Hardy-Littlewood-Sobolev inequality instead of Maximum Principle.展开更多
In this paper, we mainly consider the initial boundary problem for a quasilinear parabolic equation u_t-div(|?u|^(p-2)?u) =-|u|^(β-1) u + α|u|^(q-2 )u,where p > 1, β > 0, q≥1 and α > 0. By using Gagliard...In this paper, we mainly consider the initial boundary problem for a quasilinear parabolic equation u_t-div(|?u|^(p-2)?u) =-|u|^(β-1) u + α|u|^(q-2 )u,where p > 1, β > 0, q≥1 and α > 0. By using Gagliardo-Nirenberg type inequality, the energy method and comparison principle, the phenomena of blowup and extinction are classified completely in the different ranges of reaction exponents.展开更多
A series of novel tolane-type liquid crystals with amide group as terminal group have been prepared. The terminal amide groups were modified, and the influence of these structural parameters on liquid crystal phases w...A series of novel tolane-type liquid crystals with amide group as terminal group have been prepared. The terminal amide groups were modified, and the influence of these structural parameters on liquid crystal phases was investigated by polarizing optical microscope （POM） and differential scanning calorimetry （DSC）. Three of these new compounds exhibit nematic phase, good thermal stabilities. In general, these liquid crystals with amide as end groups have high melting points and phase transition temperatures, which result from the hydrogen bonds. Based on theoretical calculations, these new molecules with strong electron donating amide as end group have narrower HOMO-LUMO energy gap and higher dipole moment than tolane.展开更多
We revise one case of the M-solutions of B. Wang, et al., J. Diff. Eqs. 253 （2012）, pp. 3232-3265 and obtain more precise form of the singular term and the regular term.
We study the solutions with dead cores and the decay estimates for a parabolic p-Laplacian equation with absorption by sub- and supersolution method. Special attention is given to the case where the solution of the st...We study the solutions with dead cores and the decay estimates for a parabolic p-Laplacian equation with absorption by sub- and supersolution method. Special attention is given to the case where the solution of the steady-state problem vanishes in an interior region.展开更多
文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.51972119 and 52272151)the Fundamental Research Funds for the Central Universities (2022ZYGXZR015)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01X137)。
文摘Upconversion based nanothermometry has received much attention due to its merits of stability,narrow band emission and rich emission peaks.However,the previous works are mainly focused on the emissions from thermally coupled energy levels which is theoretically limited by Boltzmann distribution theory with resultant low temperature sensitivity in particular at ultralow temperatures.Here we report a LiYF_(4):Yb/Ho@LiYF_(4) core-shell nanostructure to improve the sensitivity at low temperatures by taking advantage of non-thermally coupled energy levels of Ho^(3+).In detail,the green upconversion emission of Ho^(3+)shows an increase with reducing temperature while its red upconversion emission presents a decline during the same process.This is primarily due to the suppression of the non-radiative multiphonon relaxation occurred at the green emitting levels(^(5)F_(4),^(5)S_(2)) and the intermediate level(^(5)I_(6)) at low temperatures.Such a feature contributes to a high relative sensitivity of 7.17%/K at 11 K,much higher than reported values.Our results provide a promising candidate for the development of nanothermometer with high-sensitive low-temperature sensing performance.
文摘In this paper we consider the finite time quenching behavior of solutions to a semilinear heat equation with a nonlinear Neumann boundary condition. Firstly, we establish conditions on nonlinear source and boundary to guarantee that the solution doesn＇t quench for all time. Secondly, we give sufficient conditions on data such that the solution quenches in finite time, and derive an upper bound of quenching time. Thirdly, undermore restrictive conditions, we obtain a lower bound of quenching time. Finally, we give the exact bounds of quenching time of a special example.
文摘In this paper, Liouville-type theorems of nonnegative solutions for some elliptic integral systems are considered. We use a new type of moving plane method introduced by Chen-Li-Ou. Our new ingredient is the use of Stein-Weiss inequality instead of Maximum Principle.
基金This work is supported by the National Natural Science Foundation of China(Nos.51972119 and 52272151)the Research Project of Education Department of Jiangxi Province(No.GJJ210846)the Doctoral Scientific Research Foundation of Jiangxi University of Science and Technology(No.205200100554).
文摘The luminescence in the second near-infrared(NIR-II)spectral region(1,000–1,700 nm)has recently attracted great attention for emerging biological applications owing to its merit of deep tissue bioimaging and high spatiotemporal resolution.However,it still remains a challenge to achieve the highly efficient NIR-II emissions of lanthanides in nanomaterials.Herein,we report an ideal design of sensitizing lithium sublattice core–shell nanocrystals for efficient NIR-II emission properties from a set of lanthanide emitters including Er3+,Tm3+,Ho3+,Pr3+,and Nd3+.In particular,the typical NIR-II emission of Er3+at 1.5μm was greatly enhanced by further manipulating the energy transfer via Er3+–Ce3+cross-relaxation,and the quantum yield can reach up to 35.74%under 980 nm excitation(12.5 W·cm−2),which is the highest value to the best of our knowledge.The 808 nm responsive efficient NIR-II emission was also enabled at the single-particle level through rational core–shell–shell structure design.Moreover,the lithium-sublattice provides an obvious spectral Stark-splitting feature,which can be used in the ultrasensitive NIR-II nanothermometer with relative sensitivity of 0.248%K−1 and excellent thermal cycling stability.These results open a door to the research of new kinds of efficient NIR-II luminescent materials,showing great promise in various frontier fields such as deep tissue nanothermometry and in vivo bioimaging.
文摘We study the porous medium equation ut=(um). 0<x<∞, t>0 with a singular boundary condition (um) (0,t)=u-β(0,t). We prove finite time quenching for the solution at the boundary χ=0. We also establish the quenching rate and asymptotic behavior on the quenching point.
文摘In this paper, we study the positive solutions for a class of integral systems and prove that all the solutions are radially symmetric and monotonically decreasing about some point. Moreover, we also obtain the uniqueness result for a special case. We use a new type of moving plane method introduced by Chen-Li-Ou [1]. Our new ingredient is the use of Hardy-Littlewood-Sobolev inequality instead of Maximum Principle.
基金supported by National Natural Science Foundation of China (Grant Nos. 11371286 and 11401458)the Special Fund of Education Department (Grant No. 2013JK0586)the Youth Natural Science Grant of Shaanxi Province of China (Grant No. 2013JQ1015)
文摘In this paper, we mainly consider the initial boundary problem for a quasilinear parabolic equation u_t-div(|?u|^(p-2)?u) =-|u|^(β-1) u + α|u|^(q-2 )u,where p > 1, β > 0, q≥1 and α > 0. By using Gagliardo-Nirenberg type inequality, the energy method and comparison principle, the phenomena of blowup and extinction are classified completely in the different ranges of reaction exponents.
基金The authors gratefully acknowledge the support of National Natural Science Foundation of China （No. 21272080）, Department of Science and Technology, Guangdong Province （Nos. 2010A020507001-76, 5300410, FIPL-05-003） and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.
文摘A series of novel tolane-type liquid crystals with amide group as terminal group have been prepared. The terminal amide groups were modified, and the influence of these structural parameters on liquid crystal phases was investigated by polarizing optical microscope （POM） and differential scanning calorimetry （DSC）. Three of these new compounds exhibit nematic phase, good thermal stabilities. In general, these liquid crystals with amide as end groups have high melting points and phase transition temperatures, which result from the hydrogen bonds. Based on theoretical calculations, these new molecules with strong electron donating amide as end group have narrower HOMO-LUMO energy gap and higher dipole moment than tolane.
基金The authors would thank Professor Li Yi very much for helpful discussion. Zhang is supported by the National Natural Science Foundation of China （No. 11371286, 11401458） and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.
文摘We revise one case of the M-solutions of B. Wang, et al., J. Diff. Eqs. 253 （2012）, pp. 3232-3265 and obtain more precise form of the singular term and the regular term.
文摘We study the solutions with dead cores and the decay estimates for a parabolic p-Laplacian equation with absorption by sub- and supersolution method. Special attention is given to the case where the solution of the steady-state problem vanishes in an interior region.
