Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ st...Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ studies, its clinical benefits remain modest and most often consist of temporary tumor stabilization, indicating that more effective first-line treatment regimens or second-line salvage therapies are required. The molecular pathogenesis of HCC is very complex, involving hyperactivated signal transduction pathways such as RAS/RAF/MEK/ERK and PI3K/AKT/m TOR and aberrant expression of molecules such as receptor tyrosine kinases and histone deacetylases. Simultaneous or sequential abrogation of these critical pathways or the functions of these key molecules involved in angiogenesis, proliferation, and apoptosis may yield major improvements in the management of HCC. In this review, we summarize the emerging sorafenib-based combined molecule targeting for HCC treatment and analyze the rationales of these combinations.展开更多
We study the properties of two-flavor quark matter in the equivparticle model.A new quark mass scaling at finite temperature is proposed and applied to the thermodynamics of two-flavor quark matter.It is found that th...We study the properties of two-flavor quark matter in the equivparticle model.A new quark mass scaling at finite temperature is proposed and applied to the thermodynamics of two-flavor quark matter.It is found that the perturbative interaction has strong effect on quark matter properties at finite temperature and high density.The pressure at the minimum free energy per baryon is exactly zero.With increasing temperature,the energy per baryon increases,while the free energy per baryon decreases.展开更多
文摘Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ studies, its clinical benefits remain modest and most often consist of temporary tumor stabilization, indicating that more effective first-line treatment regimens or second-line salvage therapies are required. The molecular pathogenesis of HCC is very complex, involving hyperactivated signal transduction pathways such as RAS/RAF/MEK/ERK and PI3K/AKT/m TOR and aberrant expression of molecules such as receptor tyrosine kinases and histone deacetylases. Simultaneous or sequential abrogation of these critical pathways or the functions of these key molecules involved in angiogenesis, proliferation, and apoptosis may yield major improvements in the management of HCC. In this review, we summarize the emerging sorafenib-based combined molecule targeting for HCC treatment and analyze the rationales of these combinations.
基金supported by the National Natural Science Foundation of China(Nos.11135011,11475110,and 11575190)the CAS Present’s International Fellowship Initiative(Nos.2015PM008 and2016VMA063)
文摘We study the properties of two-flavor quark matter in the equivparticle model.A new quark mass scaling at finite temperature is proposed and applied to the thermodynamics of two-flavor quark matter.It is found that the perturbative interaction has strong effect on quark matter properties at finite temperature and high density.The pressure at the minimum free energy per baryon is exactly zero.With increasing temperature,the energy per baryon increases,while the free energy per baryon decreases.
