BACKGROUND Hypocalcemia is highly common in hospitalized patients,especially in those with trauma,On the other hand,abnormal calcium metabolism is an important metabolic challenge;however,it is often neglected and unt...BACKGROUND Hypocalcemia is highly common in hospitalized patients,especially in those with trauma,On the other hand,abnormal calcium metabolism is an important metabolic challenge;however,it is often neglected and untreated,and certain factors may induce serious neurological and cardiovascular complications.AIM To retrospectively analyze the impact of hypocalcemia on the prognosis of patients with multiple traumas.METHODS The study was conducted from January 2020 to December 2021.Ninety-nine patients with multiple injuries were treated at the critical care medicine department of Fuyang People’s Hospital.The selected indicators included sex,age,and blood calcium and hematocrit levels.Many indicators were observed,including within 24 h of hospitalization,and the prognosis was collected after 28 d.Based on the blood calcium levels,the patients were divided into the following two groups:Normocalcemia and hypocalcemia.Of the 99 patients included,81 had normocalcemia,and 18 had hypocalcemia.Separate experiments were conducted for these two groups.RESULTS There was an association between serum calcium levels and the prognosis of patients with polytrauma.CONCLUSION Clinically,the prognosis of patients with multiple traumas can be preliminarily evaluated based on serum calcium levels.展开更多
Owing to the unique structure,anode-free lithium metal batteries(AFLMBs)have higher energy density and lower production cost than traditional lithium metal batteries(LMBs)or lithium-ion batteries(LIBs),However,AFLMBs ...Owing to the unique structure,anode-free lithium metal batteries(AFLMBs)have higher energy density and lower production cost than traditional lithium metal batteries(LMBs)or lithium-ion batteries(LIBs),However,AFLMBs suffer from an inherently finite Li reservoir and exhibit poor cycle stability,low Coulombic efficiency(CE)and severe dendrite growth.In this work,polydiallyl lithium disulfide(PDS-Li)was successfully synthesized and coated on Cu current collector by electrochemical polymerization.The PDS-Li acts as an additional lithium resource to compensate for the irreversible loss of lithium during cycling.In addition,the special structure and lithiophilicity of PDS-Li contribute to lower nucleation overpotential and uniform lithium deposition.When coupled with Li-rich manganese-based(LRM)cathode of Li1.2Mn0.54Ni0.13Co0.13O2,the anode-free full cell exhibits significantly improved cycle stability over 100 cycles and capacity retention of 63.3%and 57%after 80 and 100 cycles,respectively.We believe that PDS-Li can be used to ensure stable cycling performance and high-energy-density in AFLMBs.展开更多
Objective:To investigate the intervention effect and specific mechanism of Jisheng Shenqi Decoction plus Panax notoginseng and Turmeric on carbon tetrachloride(CCl4)-induced liver fibrosis in rats.Methods:SPF SD rats ...Objective:To investigate the intervention effect and specific mechanism of Jisheng Shenqi Decoction plus Panax notoginseng and Turmeric on carbon tetrachloride(CCl4)-induced liver fibrosis in rats.Methods:SPF SD rats were randomly divided into control group,model group,and Chinese medicine treatment(low,medium and high dose)groups.The model group and Chinese medicine treatment group were given intraperitoneal injection of 40%CCl4 olive oil solution twice a week.A rat model of liver fibrosis was replicated by the method for 8 weeks.After successful modeling,each drug-administered group was gavaged with corresponding drugs,and the control group and model group were gavaged with equal volume of distilled water,once a day,for 4 weeks.After the last intragastric administration,HE staining and Masson staining were used to observe the pathological morphology of liver tissue,and liver function(ALT,AST)was detected;ELISA method was used to determine transforming growth factorβ(TGF-β),angiotensin II(Ang-Ⅱ),chitinase 3-like protein 1(CHI3L1),interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)content;The expression levels of type I,type III collagen(Col-Ⅰ,Col-Ⅲ)and TGF-βmRNA were determined by RT-PCR.Results:①HE and Masson staining showed that a large number of liver cells in the model group were inflamed and necrotic,the collagen fibers in the liver tissue were extensively proliferated,the fibrous septa were interconnected,and the pseudolobules were formed.Compared with the model group,the levels of ALT,AST,TGF-β,Ang-Ⅱ,CHI3L1,IL-1,IL-6 and TNF-αin the traditional Chinese medicine treatment group were decreased,while the levels of Col-Ⅰ,Col-ⅢThe expressions ofⅢand TGF-βmRNA were decreased,and the effect was most obvious in the middle and high dose groups of traditional Chinese medicine(P<0.01).Conclusion:Jisheng Shenqi Decoction combined with Panax notoginseng and Biejia can significantly improve liver fibrosis induced by CCl4 in rats,and its mechanism may be related to the down-reg展开更多
文摘BACKGROUND Hypocalcemia is highly common in hospitalized patients,especially in those with trauma,On the other hand,abnormal calcium metabolism is an important metabolic challenge;however,it is often neglected and untreated,and certain factors may induce serious neurological and cardiovascular complications.AIM To retrospectively analyze the impact of hypocalcemia on the prognosis of patients with multiple traumas.METHODS The study was conducted from January 2020 to December 2021.Ninety-nine patients with multiple injuries were treated at the critical care medicine department of Fuyang People’s Hospital.The selected indicators included sex,age,and blood calcium and hematocrit levels.Many indicators were observed,including within 24 h of hospitalization,and the prognosis was collected after 28 d.Based on the blood calcium levels,the patients were divided into the following two groups:Normocalcemia and hypocalcemia.Of the 99 patients included,81 had normocalcemia,and 18 had hypocalcemia.Separate experiments were conducted for these two groups.RESULTS There was an association between serum calcium levels and the prognosis of patients with polytrauma.CONCLUSION Clinically,the prognosis of patients with multiple traumas can be preliminarily evaluated based on serum calcium levels.
基金financially supported by the National Natural Science Foundations of China(Nos.52071226,51872193 and U21A20332)the Natural Science Foundations of Jiangsu Province(Nos.BK20181168,BK20201171 and BK20220061)+2 种基金the Key R&D Project funded by Department of Science and Technology of Jiangsu Province(No.BE2020003-3)the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.19KJA210004)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘Owing to the unique structure,anode-free lithium metal batteries(AFLMBs)have higher energy density and lower production cost than traditional lithium metal batteries(LMBs)or lithium-ion batteries(LIBs),However,AFLMBs suffer from an inherently finite Li reservoir and exhibit poor cycle stability,low Coulombic efficiency(CE)and severe dendrite growth.In this work,polydiallyl lithium disulfide(PDS-Li)was successfully synthesized and coated on Cu current collector by electrochemical polymerization.The PDS-Li acts as an additional lithium resource to compensate for the irreversible loss of lithium during cycling.In addition,the special structure and lithiophilicity of PDS-Li contribute to lower nucleation overpotential and uniform lithium deposition.When coupled with Li-rich manganese-based(LRM)cathode of Li1.2Mn0.54Ni0.13Co0.13O2,the anode-free full cell exhibits significantly improved cycle stability over 100 cycles and capacity retention of 63.3%and 57%after 80 and 100 cycles,respectively.We believe that PDS-Li can be used to ensure stable cycling performance and high-energy-density in AFLMBs.
基金National Natural Science Foundation of China(No.81760855)Liuzhou City Liver Disease Clinical Research Center Project(No.2018AF10503)Guangxi Postgraduate Education Innovation Program(No.YCSY2020106)。
文摘Objective:To investigate the intervention effect and specific mechanism of Jisheng Shenqi Decoction plus Panax notoginseng and Turmeric on carbon tetrachloride(CCl4)-induced liver fibrosis in rats.Methods:SPF SD rats were randomly divided into control group,model group,and Chinese medicine treatment(low,medium and high dose)groups.The model group and Chinese medicine treatment group were given intraperitoneal injection of 40%CCl4 olive oil solution twice a week.A rat model of liver fibrosis was replicated by the method for 8 weeks.After successful modeling,each drug-administered group was gavaged with corresponding drugs,and the control group and model group were gavaged with equal volume of distilled water,once a day,for 4 weeks.After the last intragastric administration,HE staining and Masson staining were used to observe the pathological morphology of liver tissue,and liver function(ALT,AST)was detected;ELISA method was used to determine transforming growth factorβ(TGF-β),angiotensin II(Ang-Ⅱ),chitinase 3-like protein 1(CHI3L1),interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)content;The expression levels of type I,type III collagen(Col-Ⅰ,Col-Ⅲ)and TGF-βmRNA were determined by RT-PCR.Results:①HE and Masson staining showed that a large number of liver cells in the model group were inflamed and necrotic,the collagen fibers in the liver tissue were extensively proliferated,the fibrous septa were interconnected,and the pseudolobules were formed.Compared with the model group,the levels of ALT,AST,TGF-β,Ang-Ⅱ,CHI3L1,IL-1,IL-6 and TNF-αin the traditional Chinese medicine treatment group were decreased,while the levels of Col-Ⅰ,Col-ⅢThe expressions ofⅢand TGF-βmRNA were decreased,and the effect was most obvious in the middle and high dose groups of traditional Chinese medicine(P<0.01).Conclusion:Jisheng Shenqi Decoction combined with Panax notoginseng and Biejia can significantly improve liver fibrosis induced by CCl4 in rats,and its mechanism may be related to the down-reg
