A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes ...A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes the role of deformation degree on nucleation behavior into consideration, is coupled with an adaptive response surface model （ARSM） to search for the optimum nucleation parameter. The DRX behavior of an oxygen free high conductivity （OFHC） copper with different initial grain sizes has been taken as an example to validate the model. Good agreement is found between the simulated and the experimental results, which demonstrates that the new method can effectively improve the simulation accuracy.展开更多
Grain growth can modify the texture orientation and the fraction of different texture component.The thermal stability of two texture component in an extruded magnesium AZ31 alloy was investigated.Three types samples w...Grain growth can modify the texture orientation and the fraction of different texture component.The thermal stability of two texture component in an extruded magnesium AZ31 alloy was investigated.Three types samples with different texture distribution were prepared.The results show that normal grain growth takes place in the magnesium AZ31 alloy during annealing at 300℃ and 450℃.But the grain growth does not lead to the strengthening of either texture component.Both the<0002>⊥ED texture and<0002>//ED texture components show good thermal stability,without influence of the texture volume fraction.The two different texture component possess comparable boundary migration ability,so grains of the two texture component consume indifferently the other grains,or are equally consumed during annealing.展开更多
To improve the removal efficiency of such submicron inclusions,we designed an argon blowing method for an RH facility based on mathematical simulations.The effect of the argon blowing on the liquid steel flow and the ...To improve the removal efficiency of such submicron inclusions,we designed an argon blowing method for an RH facility based on mathematical simulations.The effect of the argon blowing on the liquid steel flow and the movement of submicron inclusions was studied using the k-ε flow model coupled with the DPM model for inclusion movement based on fluid computational dynamics in FLUENT.It was found that a more uniform argon flow can be achieved in the up-leg snorkel with a new nozzle position and inner diameter,which resulted in a favorable up-lifting and mixing movement.The new design also increased the circulation rate of molten steel in the RH chamber.The increased turbulent kinetic energy and turbulent dispersing rate enhanced the collision probability of submicron inclusions,which results in an improved removal for 0.5-1 μm inclusions.The proposed RH facility could increase the removal rate of submicron inclusions from the original 57.1% to 66.4%,which improves the magnetic properties of non-oriented silicon steel.展开更多
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses.Despite notable progress in tumor immunotherapy,nanovaccines still encounter considerable challenge...Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses.Despite notable progress in tumor immunotherapy,nanovaccines still encounter considerable challenges such as low delivery efficiency,limited targeting ability,and suboptimal efficacy.With an aim of addressing these issues,engineering customized nanovaccines through modification or functionalization has emerged as a promising approach.These tailored nanovaccines not only enhance antigen presentation,but also effectively modulate immunosuppression within the tumor microenvironment.Specifically,they are distinguished by their diverse sizes,shapes,charges,structures,and unique physicochemical properties,along with targeting ligands.These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells.This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications,offering insights into their future development and role in cancer immunotherapy.展开更多
Based on the principle of piecewise linearization, the incremental forms of microstructure evolution models were integrated into the thermo-mechanical coupled finite element（FE） model to simulate nonlinear microstru...Based on the principle of piecewise linearization, the incremental forms of microstructure evolution models were integrated into the thermo-mechanical coupled finite element（FE） model to simulate nonlinear microstructure evolution during multi-pass hot deformation. This is an unsteady-state deformation where dynamic recrystallization（DRX）, meta-dynamic recrystallization（MDRX）, static recrystallization（SRX） and grain growth（GG） take place during hot deformation or deformation interval. The distributions of deformation and microstructure for cylindrical AZ31 sample during single-pass and double-pass hot compressions were quantitatively calculated and compared with the metallographic observation. It is shown that both the deformation and microstructure are non-uniformly distributed due to the presence of friction between the die and the flat end of sample. The average grain size and its standard deviation under the double-pass hot compression are slightly smaller than those under single-pass compression.The simulated average grain sizes agree well with the experiments, which validates that the developed FE model on the basis of incremental forms of microstructure evolution models is reasonable.展开更多
In this work, pre-strain annealing strengthening(PSAS) effect was investigated in an extruded Mg-1.0Gd-1.5 Zn(wt.%) alloy with respect to different grain sizes. The evolution of microstructures was provided by scannin...In this work, pre-strain annealing strengthening(PSAS) effect was investigated in an extruded Mg-1.0Gd-1.5 Zn(wt.%) alloy with respect to different grain sizes. The evolution of microstructures was provided by scanning electron microscopy(SEM), electron backscattered diffraction(EBSD), transmission electron microscopy(TEM) and high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM) under the initial state, pre-compression, intermediate annealing and re-compression conditions. The obtained results showed a grain size-dependent PSAS effect in the alloy. The sample with larger grain sizes corresponded to a higher strengthening effect, which mainly resulted from a more remarkable hindrance for the growth of existing twins and a larger proportion of activation for the nucleation of new twins. This was closely associated with the increase of back stress and friction stress for twin boundary motion impeded by the larger restraint of dislocations, the higher stress field surrounding solutes and the more Zn segregation. In addition to twinning behavior, Guinier Preston(G.P.) zones on basaldislocations were found after intermediate annealing and provided an extra strengthening by inhibiting the motions of gilding pre-existing dislocations and newly formed ones, but it was independent on the grain size.展开更多
Detwinning behavior of a pre-twinned magnesium alloy AZ31 at cryogenic temperature was investigated,also with a focus on the annealing hardening behavior of samples with different fractions of pre-twins.Pre-compressio...Detwinning behavior of a pre-twinned magnesium alloy AZ31 at cryogenic temperature was investigated,also with a focus on the annealing hardening behavior of samples with different fractions of pre-twins.Pre-compression along the transverse direction with strains of 1.7%,3.0%,and 6.0% was applied to generated[1012]twins.Mechanical behavior,microstructure,and texture evolution during subsequent tension were examined.Our results show that low temperature did not change the fact that detwinning still pre-dominated in the pre-twinned samples under reverse loading.However,a relatively harder migration of twin boundaries was found at cryogenic temperature.An annealing hardening of 27-40 MPa was observed in the pre-twinned samples,and such a hardening effect shows a close relation with the fraction of pre-twins or the level of pre-strains.The annealing hardening effect disappeared if the matrix was consumed by twins along with the increased pre-compression strains.The corresponding reasons for the annealing hardening behavior were discussed.展开更多
Amid urbanization and the continuous expansion of transportation networks,the necessity for tunnel construction and maintenance has become paramount.Addressing this need requires the investigation of efficient,economi...Amid urbanization and the continuous expansion of transportation networks,the necessity for tunnel construction and maintenance has become paramount.Addressing this need requires the investigation of efficient,economical,and robust tunnel reinforcement techniques.This paper explores fiber reinforced polymer(FRP)and steel fiber reinforced concrete(SFRC)technologies,which have emerged as viable solutions for enhancing tunnel structures.FRP is celebrated for its lightweight and high-strength attributes,effectively augmenting load-bearing capacity and seismic resistance,while SFRC’s notable crack resistance and longevity potentially enhance the performance of tunnel segments.Nonetheless,current research predominantly focuses on experimental analysis,lacking comprehensive theoretical models.To bridge this gap,the cohesive zone model(CZM),which utilizes cohesive elements to characterize the potential fracture surfaces of concrete/SFRC,the rebar-concrete interface,and the FRP-concrete interface,was employed.A modeling approach was subsequently proposed to construct a tunnel segment model reinforced with either SFRC or FRP.Moreover,the corresponding mixed-mode constitutive models,considering interfacial friction,were integrated into the proposed model.Experimental validation and numerical simulations corroborated the accuracy of the proposed model.Additionally,this study examined the reinforcement design of tunnel segments.Through a numerical evaluation,the effectiveness of innovative reinforcement schemes,such as substituting concrete with SFRC and externally bonding FRP sheets,was assessed utilizing a case study from the Fuzhou Metro Shield Tunnel Construction Project.展开更多
基金supported by the National Basic Research Program of China (No. 2006CB705401)the National Natural Science Foundation of China (No.51075270)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.10KJD460003)
文摘A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes the role of deformation degree on nucleation behavior into consideration, is coupled with an adaptive response surface model （ARSM） to search for the optimum nucleation parameter. The DRX behavior of an oxygen free high conductivity （OFHC） copper with different initial grain sizes has been taken as an example to validate the model. Good agreement is found between the simulated and the experimental results, which demonstrates that the new method can effectively improve the simulation accuracy.
基金The current study is co-supported by National Natural Science Foundation of China(51871032,51901202)Fundamental Research Funds for the Central Universities(2019CDQYCL032)Chongqing+2 种基金111 Project by the Ministry of Education(B16007)Graduate research and innovation foundation of Chongqing,China(Grant No.CYB17004)Natural Science Foundation of Jiangsu Province(No.BK20160958).
文摘Grain growth can modify the texture orientation and the fraction of different texture component.The thermal stability of two texture component in an extruded magnesium AZ31 alloy was investigated.Three types samples with different texture distribution were prepared.The results show that normal grain growth takes place in the magnesium AZ31 alloy during annealing at 300℃ and 450℃.But the grain growth does not lead to the strengthening of either texture component.Both the<0002>⊥ED texture and<0002>//ED texture components show good thermal stability,without influence of the texture volume fraction.The two different texture component possess comparable boundary migration ability,so grains of the two texture component consume indifferently the other grains,or are equally consumed during annealing.
基金Funded by the National Natural Science Foundation of China(No.51804231)the Key R&D Program of Hubei Province(No.2020BAA027)。
文摘To improve the removal efficiency of such submicron inclusions,we designed an argon blowing method for an RH facility based on mathematical simulations.The effect of the argon blowing on the liquid steel flow and the movement of submicron inclusions was studied using the k-ε flow model coupled with the DPM model for inclusion movement based on fluid computational dynamics in FLUENT.It was found that a more uniform argon flow can be achieved in the up-leg snorkel with a new nozzle position and inner diameter,which resulted in a favorable up-lifting and mixing movement.The new design also increased the circulation rate of molten steel in the RH chamber.The increased turbulent kinetic energy and turbulent dispersing rate enhanced the collision probability of submicron inclusions,which results in an improved removal for 0.5-1 μm inclusions.The proposed RH facility could increase the removal rate of submicron inclusions from the original 57.1% to 66.4%,which improves the magnetic properties of non-oriented silicon steel.
基金financially supported by the National Key R&D Program of China(Grant No.2022YFB3808000/2022YFB3808001,Grant No.2021YFC2400600/2021 YFC2400604)the Medical Innovation Project of Science and Technology Program of Fujian Provincial Health Commission(Grant No.2021CXA006)+1 种基金the Project for High-Level Talent Innovation and Entrepreneurship of Quanzhou(Grant No.2022C016R)the Key Program of Qingyuan Innovation Laboratory(Grant No.00221002).
文摘Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses.Despite notable progress in tumor immunotherapy,nanovaccines still encounter considerable challenges such as low delivery efficiency,limited targeting ability,and suboptimal efficacy.With an aim of addressing these issues,engineering customized nanovaccines through modification or functionalization has emerged as a promising approach.These tailored nanovaccines not only enhance antigen presentation,but also effectively modulate immunosuppression within the tumor microenvironment.Specifically,they are distinguished by their diverse sizes,shapes,charges,structures,and unique physicochemical properties,along with targeting ligands.These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells.This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications,offering insights into their future development and role in cancer immunotherapy.
基金the funding support from the National Natural Science Foundation of China (Grant No. 51573156, 51675335)
文摘Based on the principle of piecewise linearization, the incremental forms of microstructure evolution models were integrated into the thermo-mechanical coupled finite element（FE） model to simulate nonlinear microstructure evolution during multi-pass hot deformation. This is an unsteady-state deformation where dynamic recrystallization（DRX）, meta-dynamic recrystallization（MDRX）, static recrystallization（SRX） and grain growth（GG） take place during hot deformation or deformation interval. The distributions of deformation and microstructure for cylindrical AZ31 sample during single-pass and double-pass hot compressions were quantitatively calculated and compared with the metallographic observation. It is shown that both the deformation and microstructure are non-uniformly distributed due to the presence of friction between the die and the flat end of sample. The average grain size and its standard deviation under the double-pass hot compression are slightly smaller than those under single-pass compression.The simulated average grain sizes agree well with the experiments, which validates that the developed FE model on the basis of incremental forms of microstructure evolution models is reasonable.
基金the financial supports from National Natural Science Foundation of China (U1764253)National Natural Science Foundation of China (51901202) and National Natural Science Foundation of China (51901204)。
文摘In this work, pre-strain annealing strengthening(PSAS) effect was investigated in an extruded Mg-1.0Gd-1.5 Zn(wt.%) alloy with respect to different grain sizes. The evolution of microstructures was provided by scanning electron microscopy(SEM), electron backscattered diffraction(EBSD), transmission electron microscopy(TEM) and high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM) under the initial state, pre-compression, intermediate annealing and re-compression conditions. The obtained results showed a grain size-dependent PSAS effect in the alloy. The sample with larger grain sizes corresponded to a higher strengthening effect, which mainly resulted from a more remarkable hindrance for the growth of existing twins and a larger proportion of activation for the nucleation of new twins. This was closely associated with the increase of back stress and friction stress for twin boundary motion impeded by the larger restraint of dislocations, the higher stress field surrounding solutes and the more Zn segregation. In addition to twinning behavior, Guinier Preston(G.P.) zones on basaldislocations were found after intermediate annealing and provided an extra strengthening by inhibiting the motions of gilding pre-existing dislocations and newly formed ones, but it was independent on the grain size.
基金co-supported by the National Natural Science Foundation of China(Nos.51901202 and 52101132)the Young Elite Scientist Sponsorship Program by CAST(YESS20230412)+4 种基金the China Postdoctoral Science Foundation(2022M713366)the Opening Project of Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology(ASMA202206)the Guangdong Basic and Applied Basic Research Foundation(2023A1515010075)the Natural Science Foundation of Jiangsu Province(No.BK 20191442)the Basic and Applied Basic Research Project of Guangzhou(202201011250).
文摘Detwinning behavior of a pre-twinned magnesium alloy AZ31 at cryogenic temperature was investigated,also with a focus on the annealing hardening behavior of samples with different fractions of pre-twins.Pre-compression along the transverse direction with strains of 1.7%,3.0%,and 6.0% was applied to generated[1012]twins.Mechanical behavior,microstructure,and texture evolution during subsequent tension were examined.Our results show that low temperature did not change the fact that detwinning still pre-dominated in the pre-twinned samples under reverse loading.However,a relatively harder migration of twin boundaries was found at cryogenic temperature.An annealing hardening of 27-40 MPa was observed in the pre-twinned samples,and such a hardening effect shows a close relation with the fraction of pre-twins or the level of pre-strains.The annealing hardening effect disappeared if the matrix was consumed by twins along with the increased pre-compression strains.The corresponding reasons for the annealing hardening behavior were discussed.
基金funded by the Scientific research startup Foundation of Fujian University of Technology(GY-Z21067 and GY-Z21026).
文摘Amid urbanization and the continuous expansion of transportation networks,the necessity for tunnel construction and maintenance has become paramount.Addressing this need requires the investigation of efficient,economical,and robust tunnel reinforcement techniques.This paper explores fiber reinforced polymer(FRP)and steel fiber reinforced concrete(SFRC)technologies,which have emerged as viable solutions for enhancing tunnel structures.FRP is celebrated for its lightweight and high-strength attributes,effectively augmenting load-bearing capacity and seismic resistance,while SFRC’s notable crack resistance and longevity potentially enhance the performance of tunnel segments.Nonetheless,current research predominantly focuses on experimental analysis,lacking comprehensive theoretical models.To bridge this gap,the cohesive zone model(CZM),which utilizes cohesive elements to characterize the potential fracture surfaces of concrete/SFRC,the rebar-concrete interface,and the FRP-concrete interface,was employed.A modeling approach was subsequently proposed to construct a tunnel segment model reinforced with either SFRC or FRP.Moreover,the corresponding mixed-mode constitutive models,considering interfacial friction,were integrated into the proposed model.Experimental validation and numerical simulations corroborated the accuracy of the proposed model.Additionally,this study examined the reinforcement design of tunnel segments.Through a numerical evaluation,the effectiveness of innovative reinforcement schemes,such as substituting concrete with SFRC and externally bonding FRP sheets,was assessed utilizing a case study from the Fuzhou Metro Shield Tunnel Construction Project.
