Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-nam...Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon fragilis.Compounds 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical calculations.Compound 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization pattern.Compounds(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid dimers.Inspired by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,respectively.Their structures were characterized using a combined method.Notably,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.展开更多
Phase relations of the Ti-Ni-Sn ternary system were investigated via alloy sampling assisted with X-ray diffractometry(XRD)and electron probe micro-analysis(EPMA).A new binary phase with composition of TiSn4(molar fra...Phase relations of the Ti-Ni-Sn ternary system were investigated via alloy sampling assisted with X-ray diffractometry(XRD)and electron probe micro-analysis(EPMA).A new binary phase with composition of TiSn4(molar fraction,%)was detected at 508 K.In addition,a supplementary phase(Ti1-x-yNixSny)Ni3(τ,AuCu3-type)was observed at 873 and 973 K.According to the characterised microscopic structure in various annealed alloys,four ternary phases were detected in Ti-Ni-Sn ternary system:TiNiSn,TiNi2Sn,Ti2Ni2Sn and(Ti1-x-yNixSny)Ni3.Additionally,isothermal sections of Ti-Ni-Sn ternary system at 508,873 and 973 K were constructed.By comparing three isothermal sections,a peri-eutectic reaction,L+TiNi2Sn→Ni3Sn4+TiNiSn,was deduced,which occurs at a temperature between 873 and 973 K.Furthermore,the solubility of Sn in TiNi and Ni in Ti5Sn3 was detected.展开更多
This paper focused on the crystal structures of two new ternary phases,Ti(Cu,Pt)2 and Ti(Cu,Pt)3,which were studied by X-ray powder diffraction data using Rietveld method.Electron probe microanalysis was used for samp...This paper focused on the crystal structures of two new ternary phases,Ti(Cu,Pt)2 and Ti(Cu,Pt)3,which were studied by X-ray powder diffraction data using Rietveld method.Electron probe microanalysis was used for sample composition examination.Elastic properties of these phases were further measured by nano-indentation,and meanwhile calculated with first-principle(FP)calculations.It is found that the crystal structure of Ti(Cu,Pt)2 is of orthorhombic cell space group Amm2(No.38)with structural prototype of VAu2.The resolved structure of Ti(Cu,Pt)3 is of tetragonal Al Pt3 type,belonging to the space group P4/mmm(No.123).The nano-indentation measurement and FP calculations show that the elastic modulus of Ti(Cu,Pt)2 increases firstly then decreases with Pt content,whereas that of Ti(Cu,Pt)3almost linearly increases with Pt content.展开更多
A chemical investigation of the 95%EtoH extract of the seeds of Cephalotaxus fortunei var.alpina led to the isolation of nine new cephalotane-type norditerpenoids,ceforalides A-I(1-9),and two known analogues(10 and 11...A chemical investigation of the 95%EtoH extract of the seeds of Cephalotaxus fortunei var.alpina led to the isolation of nine new cephalotane-type norditerpenoids,ceforalides A-I(1-9),and two known analogues(10 and 11).Compounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids,of which compound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone A-ring.Compound 9 is a rare 13,14-seco-17-nor-cephalotane-type diterpenoid.Their structures were determined based on NMR,HRESIMS,ECD,and X-ray diffraction analysis.Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity.展开更多
Phase equilibria in Ti?Ni?Pt ternary system have been experimentally determined through diffusion triple technique combined with alloy samples approach.Assisted with electron probe microanalysis(EPMA)and X-ray diffrac...Phase equilibria in Ti?Ni?Pt ternary system have been experimentally determined through diffusion triple technique combined with alloy samples approach.Assisted with electron probe microanalysis(EPMA)and X-ray diffraction(XRD)techniques,isothermal sections at 1073 and 1173 K of this system were constructed and existence of ternary phase Ti2(Ni,Pt)3 was confirmed.In addition,binary compounds Ti3Pt5 and TiPt3-were found to be stable at 1073 and 1173 K,and remarkable ternary solubility in some binary compounds was detected,e.g.,solubility of Pt in TiNi can be up to about 36%(molar fraction)at 1073 K and 40%(molar fraction)at 1173 K.Furthermore,a ternary invariant transition reaction TiNi3+Ti3Pt5→Ti2(Ni,Pt)3+TiPt3+at a temperature between 1073 and 1173 K was deduced.展开更多
Soluble and ordered ladder like polyphenylsilsesquioxane was synthesized by a two-step sol-gel method including hydrolysis and polycondensation. The procedure was monitored by Fourier transform infrared spectroscopy a...Soluble and ordered ladder like polyphenylsilsesquioxane was synthesized by a two-step sol-gel method including hydrolysis and polycondensation. The procedure was monitored by Fourier transform infrared spectroscopy and the presence of the ladder like structure was confirmed by X-ray techniques. 29Si NMR analysis shows a very narrow half peak width（δ4） at δ –78.866 of the main chain unit C6H5SiO3/2 of polyphenylsilsesquioxane, indicating that the polyphenylsilsesquioxane has ordered ladder like structures rather than the branched ones. The relationship between molecular weight and the time of polycondensation was also discussed.展开更多
目的 :探讨游离腓骨肌-皮-筋膜复合瓣在修复下颌骨放射性骨坏死(osteoradionecrosis of the jaws,ORNJ)术后软、硬组织缺损的应用价值。方法:选择2014年3月—2017年7月间,中山大学孙逸仙纪念医院口腔颌面外科40例下颌骨ORNJ患者,所有病...目的 :探讨游离腓骨肌-皮-筋膜复合瓣在修复下颌骨放射性骨坏死(osteoradionecrosis of the jaws,ORNJ)术后软、硬组织缺损的应用价值。方法:选择2014年3月—2017年7月间,中山大学孙逸仙纪念医院口腔颌面外科40例下颌骨ORNJ患者,所有病例原发肿瘤均为鼻咽癌,排除鼻咽癌复发。以游离腓骨肌-皮-筋膜复合瓣重建放射性下颌骨坏死手术切除后的骨缺损,以皮岛修复皮肤软组织缺损,以筋膜修复口内黏膜缺损并充填软组织缺损的空腔,记录腓骨截骨、组织瓣存活情况,供区、受区并发症,术后开口度和余留牙咬合情况,对颌面部外形和功能进行评价。结果:随访3~6个月,游离腓骨肌-皮-筋膜复合瓣重建下颌骨缺损均获成功。下颌骨截骨长度5.5~16.0 cm,切取腓骨长度7.5~17.0 cm。无1例发生严重供区或受区并发症,所有病例外形恢复良好,开口度1.0~3.5 cm,余留牙咬合正常。结论:游离腓骨肌-皮-筋膜复合瓣能很好地即刻重建放射性下颌骨坏死术后颌面部软、硬组织缺损,降低手术并发症,值得临床推广应用。展开更多
基金support from the National Natural Science Foundation of China(22237007 and 22177122)the Biological Resources Program of Chinese Academy of Sciences(CAS)(KFJ-BRP-008-001)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022282)is gratefully acknowledged.We thank Prof.Shi-Man Huang,Department of Biology,Hainan University,China,for the identification of the plant material.
文摘Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon fragilis.Compounds 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical calculations.Compound 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization pattern.Compounds(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid dimers.Inspired by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,respectively.Their structures were characterized using a combined method.Notably,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.
基金Project(2016YFB0701404)supported by the National Key Research and Development Program of ChinaProject(51171210)supported by the National Natural Science Foundation of ChinaProject(2014CB6644002)supported by the National Basic Research Program of China
文摘Phase relations of the Ti-Ni-Sn ternary system were investigated via alloy sampling assisted with X-ray diffractometry(XRD)and electron probe micro-analysis(EPMA).A new binary phase with composition of TiSn4(molar fraction,%)was detected at 508 K.In addition,a supplementary phase(Ti1-x-yNixSny)Ni3(τ,AuCu3-type)was observed at 873 and 973 K.According to the characterised microscopic structure in various annealed alloys,four ternary phases were detected in Ti-Ni-Sn ternary system:TiNiSn,TiNi2Sn,Ti2Ni2Sn and(Ti1-x-yNixSny)Ni3.Additionally,isothermal sections of Ti-Ni-Sn ternary system at 508,873 and 973 K were constructed.By comparing three isothermal sections,a peri-eutectic reaction,L+TiNi2Sn→Ni3Sn4+TiNiSn,was deduced,which occurs at a temperature between 873 and 973 K.Furthermore,the solubility of Sn in TiNi and Ni in Ti5Sn3 was detected.
基金Projects(2016YFB07014042016YFB0701301)supported by the National Key Research and Development Program of China。
文摘This paper focused on the crystal structures of two new ternary phases,Ti(Cu,Pt)2 and Ti(Cu,Pt)3,which were studied by X-ray powder diffraction data using Rietveld method.Electron probe microanalysis was used for sample composition examination.Elastic properties of these phases were further measured by nano-indentation,and meanwhile calculated with first-principle(FP)calculations.It is found that the crystal structure of Ti(Cu,Pt)2 is of orthorhombic cell space group Amm2(No.38)with structural prototype of VAu2.The resolved structure of Ti(Cu,Pt)3 is of tetragonal Al Pt3 type,belonging to the space group P4/mmm(No.123).The nano-indentation measurement and FP calculations show that the elastic modulus of Ti(Cu,Pt)2 increases firstly then decreases with Pt content,whereas that of Ti(Cu,Pt)3almost linearly increases with Pt content.
基金This work was supported by the National Natural Science Foundation of China(Nos.81872758,21907099)Science and Technology Commission of Shanghai Municipality(19YF1457000)。
文摘A chemical investigation of the 95%EtoH extract of the seeds of Cephalotaxus fortunei var.alpina led to the isolation of nine new cephalotane-type norditerpenoids,ceforalides A-I(1-9),and two known analogues(10 and 11).Compounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids,of which compound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone A-ring.Compound 9 is a rare 13,14-seco-17-nor-cephalotane-type diterpenoid.Their structures were determined based on NMR,HRESIMS,ECD,and X-ray diffraction analysis.Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity.
基金Project(2016YFB0701404)supported by the National Key Research and Development Program of ChinaProject(51171210)supported by the National Natural Science Foundation of China
文摘Phase equilibria in Ti?Ni?Pt ternary system have been experimentally determined through diffusion triple technique combined with alloy samples approach.Assisted with electron probe microanalysis(EPMA)and X-ray diffraction(XRD)techniques,isothermal sections at 1073 and 1173 K of this system were constructed and existence of ternary phase Ti2(Ni,Pt)3 was confirmed.In addition,binary compounds Ti3Pt5 and TiPt3-were found to be stable at 1073 and 1173 K,and remarkable ternary solubility in some binary compounds was detected,e.g.,solubility of Pt in TiNi can be up to about 36%(molar fraction)at 1073 K and 40%(molar fraction)at 1173 K.Furthermore,a ternary invariant transition reaction TiNi3+Ti3Pt5→Ti2(Ni,Pt)3+TiPt3+at a temperature between 1073 and 1173 K was deduced.
基金Supported by the National Natural Science Foundation of China(No.51073020)the Program for Changjiang Scholars and Innovative Research Team in University of China(No.IRT0706)
文摘Soluble and ordered ladder like polyphenylsilsesquioxane was synthesized by a two-step sol-gel method including hydrolysis and polycondensation. The procedure was monitored by Fourier transform infrared spectroscopy and the presence of the ladder like structure was confirmed by X-ray techniques. 29Si NMR analysis shows a very narrow half peak width（δ4） at δ –78.866 of the main chain unit C6H5SiO3/2 of polyphenylsilsesquioxane, indicating that the polyphenylsilsesquioxane has ordered ladder like structures rather than the branched ones. The relationship between molecular weight and the time of polycondensation was also discussed.
文摘目的 :探讨游离腓骨肌-皮-筋膜复合瓣在修复下颌骨放射性骨坏死(osteoradionecrosis of the jaws,ORNJ)术后软、硬组织缺损的应用价值。方法:选择2014年3月—2017年7月间,中山大学孙逸仙纪念医院口腔颌面外科40例下颌骨ORNJ患者,所有病例原发肿瘤均为鼻咽癌,排除鼻咽癌复发。以游离腓骨肌-皮-筋膜复合瓣重建放射性下颌骨坏死手术切除后的骨缺损,以皮岛修复皮肤软组织缺损,以筋膜修复口内黏膜缺损并充填软组织缺损的空腔,记录腓骨截骨、组织瓣存活情况,供区、受区并发症,术后开口度和余留牙咬合情况,对颌面部外形和功能进行评价。结果:随访3~6个月,游离腓骨肌-皮-筋膜复合瓣重建下颌骨缺损均获成功。下颌骨截骨长度5.5~16.0 cm,切取腓骨长度7.5~17.0 cm。无1例发生严重供区或受区并发症,所有病例外形恢复良好,开口度1.0~3.5 cm,余留牙咬合正常。结论:游离腓骨肌-皮-筋膜复合瓣能很好地即刻重建放射性下颌骨坏死术后颌面部软、硬组织缺损,降低手术并发症,值得临床推广应用。
