Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary ap...Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.展开更多
Objective:To compare the biological characteristics and stability of the chronic non-bacterial prostatitis(CNP)model in rats induced by the depot combined with estrogen induction method and the autoimmune response ind...Objective:To compare the biological characteristics and stability of the chronic non-bacterial prostatitis(CNP)model in rats induced by the depot combined with estrogen induction method and the autoimmune response induction method.Methods:The CNP rat model was prepared using the depot combined with 17β-estradiol induction method in the depot hormone group and three concentrations of prostate protein homogenate at 40 mg/mL,20 mg/mL and 10 mg/mL in the autoimmune group,respectively.The degree of prostate tissue damage was evaluated by pathology(HE staining),and the immunoturbidimetric method was used to evaluate the contents of immunoglobulins IgA,IgM and IgG.ELISA was used to evaluate interleukin-1β(IL-1β),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and high-sensitivity-C-reactive protein(hs-CRP),and electrochemiluminescence was used to evaluate the expression level of testosterone(T),and the two model methods were compared.Results:Compared with the sham-operated group,the body mass of rats in both models was significantly lower in the depot hormone group and autoimmune group before extraction(P<0.01,P<0.01),and histopathology of the prostate in both models showed destruction of glandular structure and a significant increase in inflammatory cells.Compared with the depot hormone group and the autoimmune group,the histopathological changes and inflammatory pathological scores of prostate and the contents of immune indexes IgA,IgM and IgG were significantly different in the depot hormone group(P<0.05,P<0.05,P<0.05),and the levels of IL-1β,IL-10,TNF-α,hs-CRP and T were significantly changed in the autoimmune group(P<0.01).The comparison between the high,medium and low dose groups of the autoimmune group,in which the pathological changes in the medium dose of the autoimmune group were slightly better than the other two groups between the groups,but the changes in IL-1β,IL-10,TNF-α,hs-CRP,and T in the low dose of the autoimmune group were the most significant(P<0.05).Conclusion:The pathological tissues 展开更多
Comprehensive and joint applications of GIS and chemometric approach were applied in identification and spatial patterns of coastal water pollution sources with a large data set （5 years （2000-2004）, 17 parameters...Comprehensive and joint applications of GIS and chemometric approach were applied in identification and spatial patterns of coastal water pollution sources with a large data set （5 years （2000-2004）, 17 parameters） obtained through coastal water monitoring of Southern Water Control Zone in Hong Kong. According to cluster analysis the pollution degree was significantly different between September-next May （the 1st period） and June-August （the 2nd period）. Based on these results, four potential pollution sources, such as organic/eutrophication pollution, natural pollution, mineral/anthropic pollution and fecal pollution were identified by factor analysis/principal component analysis. Then the factor scores of each monitoring site were analyzed using inverse distance weighting method, and the results indicated degree of the influence by various potential pollution sources differed among the monitoring sites. This study indicated that hybrid approach was useful and effective for identification of coastal water pollution source and spatial patterns.展开更多
Recognizing the potential of globalizing traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),this review summarizes the current global use of TCM for COVID-19,status of the internationalization of ...Recognizing the potential of globalizing traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),this review summarizes the current global use of TCM for COVID-19,status of the internationalization of TCM,and strategy on globalizing TCM for COVID-19.COVID-19 is a novel coronavirus disease that has sparked a pandemic in March 2020 affecting over 110 countries.Although researchers have been racing to develop targeted anti-COVID-19 treatment and vaccine,they are still currently unavailable.Thus,in treating patients infected with COVID-19,western medicine mainly recommended symptomatic treatment and monitoring.Existing drugs are used in the context of clinical trials,and the FDA still not yet approved these drugs for COVID-19.On the other hand,TCM proposed herbal treatment for suspected individuals to take within their observation period,as well as for confirmed COVID-19 patients to take during active phase of disease and during recovery.In China,Integrative Chinese-Western Medicine had been used in treating 91.5%of COVID-19 patients and showed its strength in reducing disease severity,shortening recovery time,and lowering the mortality rate.Despite obstacles in globalizing TCM for the treatment of COVID-19,promoting appropriate use of locally registered TCM products may prevent disease in susceptible individuals,improve the quality of life,and assist in the recovery of COVID-19 patients.With increasing global acceptance,TCM may play a more important role in the battle against infectious disease in the future.展开更多
Bursty traffic and thousands of concurrent flows incur inevitable network congestion in datacenter networks(DCNs)and then affect the overall performance.Various transport protocols are developed to mitigate the networ...Bursty traffic and thousands of concurrent flows incur inevitable network congestion in datacenter networks(DCNs)and then affect the overall performance.Various transport protocols are developed to mitigate the network congestion,including reactive and proactive protocols.Reactive schemes use different congestion signals,such as explicit congestion notification(ECN)and round trip time(RTT),to handle the network congestion after congestion arises.However,with the growth of scale and link speed in datacenters,reactive schemes encounter a significant problem of slow responding to congestion.On the contrary,proactive protocols(e.g.,credit-reservation protocols)are designed to avoid congestion before it occurs,and they have the advantages of zero data loss,fast convergence and low buffer occupancy.But credit-reservation protocols have not been widely deployed in current DCNs(e.g.,Microsoft,Amazon),which mainly deploy ECN-based protocols,such as data center transport control protocol(DCTCP)and data center quantized congestion notification(DCQCN).And in an actual deployment scenario,it is hard to guarantee one protocol to be deployed in every server at one time.When credit-reservation protocol is deployed to DCNs step by step,the network will be converted to multi-protocol state and will face the following fundamental challenges:1)unfairness,2)high buffer occupancy,and 3)heavy tail latency.Therefore,we propose Harmonia,aiming for converging ECN-based and credit-reservation protocols to fairness with minimal modification.To the best of our knowledge,Harmonia is the first to address the trouble of harmonizing proactive and reactive congestion control.Targeting the common ECN-based protocols-DCTCP and DCQCN,Harmonia leverages forward ECN and RTT to deliver real-time congestion information and redefines feedback control.After the evaluation,the results show that Harmonia effectively solves the unfair link allocation,eliminating the timeouts and addressing the buffer overflow.展开更多
BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a rare severe complication after renal transplantation, with an incidence of approximately 0.3%-2.0% in patients undergoing renal transplantation. The c...BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a rare severe complication after renal transplantation, with an incidence of approximately 0.3%-2.0% in patients undergoing renal transplantation. The clinical manifestations of PTLD are often nonspecific, leading to tremendous challenges in the clinical diagnosis and treatment of PTLD.CASE SUMMARY We report two Epstein-Barr virus(EBV)-positive PTLD cases whose main clinical manifestations were digestive tract symptoms. Both of them admitted to our hospital because of extranodal infiltration symptoms and we did not suspect of PTLD until the pathology confirmation. Luckily, they responded well to the treatment of rituximab. We also discuss the virological monitoring, clinical characteristics, diagnosis, and treatment of PTLD.CONCLUSION PTLD is a deceptive disease and difficult to diagnose. Once patients are confirmed with PTLD, immune suppressant dosage should be immediately reduced and rituximab should be used as first-line therapy.展开更多
In this paper,we study the large time behavior of solutions to a class of fast diffusion equations with nonlinear boundary sources on the exterior domain of the unit ball.We are interested in the critical global expon...In this paper,we study the large time behavior of solutions to a class of fast diffusion equations with nonlinear boundary sources on the exterior domain of the unit ball.We are interested in the critical global exponent q_o and the critical Fujita exponent q_c for the problem considered,and show that q_o=q_c for the multidimensional Non-Newtonian polytropic filtration equation with nonlinear boundary sources,which is quite different from the known results that q_o〈q_c for the onedimensional case;moreover,the value is different from the slow case.展开更多
Objective: Provide a rapid and simple method to identify Yunpian Lurong. Method: Terahertz spectroscopy was used to detect Yunpian Lurong. Result: Compared with the reference wave, the spectral amplitude of Yunpian Lu...Objective: Provide a rapid and simple method to identify Yunpian Lurong. Method: Terahertz spectroscopy was used to detect Yunpian Lurong. Result: Compared with the reference wave, the spectral amplitude of Yunpian Lurong decreases significantly. The frequency - domain spectra of Yunpian Lurong are different from conventional Lurong. Compared with the spectrum of free space, both of them have obvious absorption to THz wave, but the intensity and location of absorption are different, which provides a basis for the identification of Yunpian Lurong. The refractive index of the two samples is obviously different, which may be related to the different internal structure and composition content of the samples. The absorption coefficient of the two samples are different as well, when the frequency ranges from 0 to 2.4 THz, the absorption coefficients of the two kinds of Lurong samples have obvious difference, which makes it easy to distinguish the Yunpian Lurong. Conclusion: This study proves that terahertz spectroscopy can be used as an efficient and convenient method to identify Yunpian Lurong.展开更多
Hemolytic uremic syndrome （HUS） is a rare disease characterized by thrombocytopenia and acute renal failure. Atypical HUS （aHUS） accounts for approximately 10% of all HUS cases. The pathogenesis of aHUS is mainly ...Hemolytic uremic syndrome （HUS） is a rare disease characterized by thrombocytopenia and acute renal failure. Atypical HUS （aHUS） accounts for approximately 10% of all HUS cases. The pathogenesis of aHUS is mainly associated with gene mutations in complement factor H, complement factor I, and membrane cofactor protein （MCP）. The prognosis of aHUS is generally poor.展开更多
This paper is concerned with the bifurcation analysis for a free boundary problem modeling the growth of solid tumor with inhibitors.In this problem,surface tension coefficient plays the role of bifurcation parameter,...This paper is concerned with the bifurcation analysis for a free boundary problem modeling the growth of solid tumor with inhibitors.In this problem,surface tension coefficient plays the role of bifurcation parameter,it is proved that there exists a sequence of the nonradially stationary solutions bifurcate from the radially symmetric stationary solutions.Our results indicate that the tumor grown in vivo may have various shapes.In particular,a tumor with an inhibitor is associated with the growth of protrusions.展开更多
Objective: In order to identify the quality of different geological conditions and plant ages of Xiling Zhimu. Methods: This article uses the terahertz spectroscopy to detect and analyze different geological condition...Objective: In order to identify the quality of different geological conditions and plant ages of Xiling Zhimu. Methods: This article uses the terahertz spectroscopy to detect and analyze different geological conditions and ages of Zhimu (Anemarrhenae Rhizoma) from the same origin. Results: The terahertz time-domain spectroscopy of different geological conditions and ages has a decrease relative to the reference amplitude and has a delay. The refractive index has obvious differences, and the refractive index can be used as a way to identify the tablets. The absorption coefficients of different ages Zhimu samples has significant differences in the range of 1.0-2.0 THz. The absorption coefficients of different geological conditions Zhimu samples has significant differences in the range of 1.1-2.0 THz. Conclusions: The differences caused by different production methods should be considered in the identification of genuine regional drug. When the Zhimu is grown due to different geological conditions and plant ages, its efficacy will also change. we can detect this change by terahertz spectroscopy.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12150006)Shanghai Pilot Program for Basic Research—Shanghai Jiao Tong University(Grant No.21TQ1400209)。
文摘Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.
基金National Natural Science Foundation Project(82104881)Major Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A02205)。
文摘Objective:To compare the biological characteristics and stability of the chronic non-bacterial prostatitis(CNP)model in rats induced by the depot combined with estrogen induction method and the autoimmune response induction method.Methods:The CNP rat model was prepared using the depot combined with 17β-estradiol induction method in the depot hormone group and three concentrations of prostate protein homogenate at 40 mg/mL,20 mg/mL and 10 mg/mL in the autoimmune group,respectively.The degree of prostate tissue damage was evaluated by pathology(HE staining),and the immunoturbidimetric method was used to evaluate the contents of immunoglobulins IgA,IgM and IgG.ELISA was used to evaluate interleukin-1β(IL-1β),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and high-sensitivity-C-reactive protein(hs-CRP),and electrochemiluminescence was used to evaluate the expression level of testosterone(T),and the two model methods were compared.Results:Compared with the sham-operated group,the body mass of rats in both models was significantly lower in the depot hormone group and autoimmune group before extraction(P<0.01,P<0.01),and histopathology of the prostate in both models showed destruction of glandular structure and a significant increase in inflammatory cells.Compared with the depot hormone group and the autoimmune group,the histopathological changes and inflammatory pathological scores of prostate and the contents of immune indexes IgA,IgM and IgG were significantly different in the depot hormone group(P<0.05,P<0.05,P<0.05),and the levels of IL-1β,IL-10,TNF-α,hs-CRP and T were significantly changed in the autoimmune group(P<0.01).The comparison between the high,medium and low dose groups of the autoimmune group,in which the pathological changes in the medium dose of the autoimmune group were slightly better than the other two groups between the groups,but the changes in IL-1β,IL-10,TNF-α,hs-CRP,and T in the low dose of the autoimmune group were the most significant(P<0.05).Conclusion:The pathological tissues
基金Project supported by the National Basic Research Program (973) of China(No. 2005CB724205)China Scholarship Programs of the Ministry ofEducation of China (No. 2006100766).
文摘Comprehensive and joint applications of GIS and chemometric approach were applied in identification and spatial patterns of coastal water pollution sources with a large data set （5 years （2000-2004）, 17 parameters） obtained through coastal water monitoring of Southern Water Control Zone in Hong Kong. According to cluster analysis the pollution degree was significantly different between September-next May （the 1st period） and June-August （the 2nd period）. Based on these results, four potential pollution sources, such as organic/eutrophication pollution, natural pollution, mineral/anthropic pollution and fecal pollution were identified by factor analysis/principal component analysis. Then the factor scores of each monitoring site were analyzed using inverse distance weighting method, and the results indicated degree of the influence by various potential pollution sources differed among the monitoring sites. This study indicated that hybrid approach was useful and effective for identification of coastal water pollution source and spatial patterns.
基金supported National Natural Science Foundation of China(Grant No.81973438,81803571)National Major Scientific and Technological Special Project for“Significant New Drugs Development”(Grant No.2019ZX09301-140)
文摘Recognizing the potential of globalizing traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),this review summarizes the current global use of TCM for COVID-19,status of the internationalization of TCM,and strategy on globalizing TCM for COVID-19.COVID-19 is a novel coronavirus disease that has sparked a pandemic in March 2020 affecting over 110 countries.Although researchers have been racing to develop targeted anti-COVID-19 treatment and vaccine,they are still currently unavailable.Thus,in treating patients infected with COVID-19,western medicine mainly recommended symptomatic treatment and monitoring.Existing drugs are used in the context of clinical trials,and the FDA still not yet approved these drugs for COVID-19.On the other hand,TCM proposed herbal treatment for suspected individuals to take within their observation period,as well as for confirmed COVID-19 patients to take during active phase of disease and during recovery.In China,Integrative Chinese-Western Medicine had been used in treating 91.5%of COVID-19 patients and showed its strength in reducing disease severity,shortening recovery time,and lowering the mortality rate.Despite obstacles in globalizing TCM for the treatment of COVID-19,promoting appropriate use of locally registered TCM products may prevent disease in susceptible individuals,improve the quality of life,and assist in the recovery of COVID-19 patients.With increasing global acceptance,TCM may play a more important role in the battle against infectious disease in the future.
基金supported by the National Key Research and Development Program of China under Grant No.2018YFB0204300the National Postdoctoral Program for Innovative Talents under Grant No.BX20190091Excellent Youth Foundation of Hunan Province(De-Zun Dong).
文摘Bursty traffic and thousands of concurrent flows incur inevitable network congestion in datacenter networks(DCNs)and then affect the overall performance.Various transport protocols are developed to mitigate the network congestion,including reactive and proactive protocols.Reactive schemes use different congestion signals,such as explicit congestion notification(ECN)and round trip time(RTT),to handle the network congestion after congestion arises.However,with the growth of scale and link speed in datacenters,reactive schemes encounter a significant problem of slow responding to congestion.On the contrary,proactive protocols(e.g.,credit-reservation protocols)are designed to avoid congestion before it occurs,and they have the advantages of zero data loss,fast convergence and low buffer occupancy.But credit-reservation protocols have not been widely deployed in current DCNs(e.g.,Microsoft,Amazon),which mainly deploy ECN-based protocols,such as data center transport control protocol(DCTCP)and data center quantized congestion notification(DCQCN).And in an actual deployment scenario,it is hard to guarantee one protocol to be deployed in every server at one time.When credit-reservation protocol is deployed to DCNs step by step,the network will be converted to multi-protocol state and will face the following fundamental challenges:1)unfairness,2)high buffer occupancy,and 3)heavy tail latency.Therefore,we propose Harmonia,aiming for converging ECN-based and credit-reservation protocols to fairness with minimal modification.To the best of our knowledge,Harmonia is the first to address the trouble of harmonizing proactive and reactive congestion control.Targeting the common ECN-based protocols-DCTCP and DCQCN,Harmonia leverages forward ECN and RTT to deliver real-time congestion information and redefines feedback control.After the evaluation,the results show that Harmonia effectively solves the unfair link allocation,eliminating the timeouts and addressing the buffer overflow.
基金Supported by the National Natural Science Foundation of China,No.81771720
文摘BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a rare severe complication after renal transplantation, with an incidence of approximately 0.3%-2.0% in patients undergoing renal transplantation. The clinical manifestations of PTLD are often nonspecific, leading to tremendous challenges in the clinical diagnosis and treatment of PTLD.CASE SUMMARY We report two Epstein-Barr virus(EBV)-positive PTLD cases whose main clinical manifestations were digestive tract symptoms. Both of them admitted to our hospital because of extranodal infiltration symptoms and we did not suspect of PTLD until the pathology confirmation. Luckily, they responded well to the treatment of rituximab. We also discuss the virological monitoring, clinical characteristics, diagnosis, and treatment of PTLD.CONCLUSION PTLD is a deceptive disease and difficult to diagnose. Once patients are confirmed with PTLD, immune suppressant dosage should be immediately reduced and rituximab should be used as first-line therapy.
基金The Fundamental Research Funds for the Central Universities and the NSF(11071100) of China
文摘In this paper,we study the large time behavior of solutions to a class of fast diffusion equations with nonlinear boundary sources on the exterior domain of the unit ball.We are interested in the critical global exponent q_o and the critical Fujita exponent q_c for the problem considered,and show that q_o=q_c for the multidimensional Non-Newtonian polytropic filtration equation with nonlinear boundary sources,which is quite different from the known results that q_o〈q_c for the onedimensional case;moreover,the value is different from the slow case.
文摘Objective: Provide a rapid and simple method to identify Yunpian Lurong. Method: Terahertz spectroscopy was used to detect Yunpian Lurong. Result: Compared with the reference wave, the spectral amplitude of Yunpian Lurong decreases significantly. The frequency - domain spectra of Yunpian Lurong are different from conventional Lurong. Compared with the spectrum of free space, both of them have obvious absorption to THz wave, but the intensity and location of absorption are different, which provides a basis for the identification of Yunpian Lurong. The refractive index of the two samples is obviously different, which may be related to the different internal structure and composition content of the samples. The absorption coefficient of the two samples are different as well, when the frequency ranges from 0 to 2.4 THz, the absorption coefficients of the two kinds of Lurong samples have obvious difference, which makes it easy to distinguish the Yunpian Lurong. Conclusion: This study proves that terahertz spectroscopy can be used as an efficient and convenient method to identify Yunpian Lurong.
文摘Hemolytic uremic syndrome （HUS） is a rare disease characterized by thrombocytopenia and acute renal failure. Atypical HUS （aHUS） accounts for approximately 10% of all HUS cases. The pathogenesis of aHUS is mainly associated with gene mutations in complement factor H, complement factor I, and membrane cofactor protein （MCP）. The prognosis of aHUS is generally poor.
基金The NSF(11361029)of Chinathe NSF(20142BAB211001)of Jiangxi Province
文摘This paper is concerned with the bifurcation analysis for a free boundary problem modeling the growth of solid tumor with inhibitors.In this problem,surface tension coefficient plays the role of bifurcation parameter,it is proved that there exists a sequence of the nonradially stationary solutions bifurcate from the radially symmetric stationary solutions.Our results indicate that the tumor grown in vivo may have various shapes.In particular,a tumor with an inhibitor is associated with the growth of protrusions.
文摘Objective: In order to identify the quality of different geological conditions and plant ages of Xiling Zhimu. Methods: This article uses the terahertz spectroscopy to detect and analyze different geological conditions and ages of Zhimu (Anemarrhenae Rhizoma) from the same origin. Results: The terahertz time-domain spectroscopy of different geological conditions and ages has a decrease relative to the reference amplitude and has a delay. The refractive index has obvious differences, and the refractive index can be used as a way to identify the tablets. The absorption coefficients of different ages Zhimu samples has significant differences in the range of 1.0-2.0 THz. The absorption coefficients of different geological conditions Zhimu samples has significant differences in the range of 1.1-2.0 THz. Conclusions: The differences caused by different production methods should be considered in the identification of genuine regional drug. When the Zhimu is grown due to different geological conditions and plant ages, its efficacy will also change. we can detect this change by terahertz spectroscopy.
