AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury....AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P【0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF.展开更多
Erigoster A (la), a new compound with a novel basic skeleton, was isolated from Erigeron breviscapus. The structure elucidation and complete proton and carbon NMR assignments were achieved by the utilization of a comb...Erigoster A (la), a new compound with a novel basic skeleton, was isolated from Erigeron breviscapus. The structure elucidation and complete proton and carbon NMR assignments were achieved by the utilization of a combination of two-dimensional NMR techniques.展开更多
The impacts of different 03 concentration on the biomass and yield of rice were studied by using OTC-1 open-top chambers. Experimental treatments included the activated charcoal-filtered air. (CFA), 50 nl/L (CF50), 10...The impacts of different 03 concentration on the biomass and yield of rice were studied by using OTC-1 open-top chambers. Experimental treatments included the activated charcoal-filtered air. (CFA), 50 nl/L (CF50), 100 nl/L ( CF100) and 200 nl/L (CF200) concentrations of O-3. The O-3 treatments significantly decreased the total biomass per plant. The. elevated O-3 exposure resulted in a more decrease in the root growth than in the shoot growth. Assessments of yield characteristics at the final harvest revealed an O-3-induced decrease in the number of grains per plant, resulting from fewer ears per plant, fewer grains per ear and more unfilled grains per ear. The 1000 grain dry weight and the harvest index (HI) were not changed significantly under 50 nl/L or 100 nl/L O-3 exposure, but reduced by 17.0% and 4.8% by 200nl/L O-3 treatment, respectively. Compared to the CFA treatment, CF50, CF100 and CF200 treatments caused a 8.2%, 26.1%, 49.1% decrease of the grain yield per plant, and a 14.2%, 31.7%, 51.7% decrease of the total biomass per plant, respectively. Linear regression showed that the 7h - daily mean O-3 concentration exposure for 3 months ( July-September) and AOT40 ( cunulative exposure accumulation over threshold 40 nl/L) were well correlated with the relative grain yield. A yield loss of 10% was estimated to be at 46.9 nl/L O-3 for 7h-daily mean O-3 concentration exposure or at 12930nl/(L(.)h) O-3 for AOT40.展开更多
BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in m...BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure s展开更多
Phytochemical re-investigation of the anti-leukemia plant Laggera pterodonta afford four new eudemsanes (1-4) and six new eudesmanoic glucosides (5-10), Their structures were elucidated by high field 1D and 2D NMR tec...Phytochemical re-investigation of the anti-leukemia plant Laggera pterodonta afford four new eudemsanes (1-4) and six new eudesmanoic glucosides (5-10), Their structures were elucidated by high field 1D and 2D NMR techniques and chemical methods.展开更多
Four new diterpenoids named maoecrystal Q-T (1-4) were isolated from the dried leaves of Isodon eriocalyx. Their sturctures were established by spectroscopic methods.
AIM To elucidate the effect of various solutions for small bowel graft preservation in pigs under hypothermic storage. METHODS The swine segmental small bowel graft was autotransplanted after it was preserved with ...AIM To elucidate the effect of various solutions for small bowel graft preservation in pigs under hypothermic storage. METHODS The swine segmental small bowel graft was autotransplanted after it was preserved with lactated Ringer′s (LR), Euro Collins (EC), hyperosmolarity citrate adenine (HC A) and WMO 1 solutions for 10, 18 and 24 hours, respectively. The recipient survival rate, morphological structure, graft mucosal energy substances and Na + K + ATPase activity were studied, and graft absorption was estimated with D xylose absorption test. RESULTS The morphological study of the grafts preserved with LR or HC A solution for 10 hours or with EC and WMO 1 solution for 18 hours was normal 6 days after operation. Mucosal ATP, total adenine nucleotides (TAN) contents and Na + K + ATPase activity of the graft preserved with EC or WMO solution were higher than that of the graft preserved with LR or HC A solution. Serum level of D xylose was higher in EC and WMO 1 groups than in LR and HC A groups when the graft was preserved for 24 hours. CONCLUSIONS EC and WMO 1 solutions can preserve the swine small bowel up to 18 hours, which are superior to LR and HC A solutions.展开更多
Ceratoside A (1), a new compound was isolated from the butanol-soluble fraction of Ceratostigma willmottianum, Its structure was determined by the utilization of 2D-NMR techniques.
Eucaglobulin 1, a new complex of gallotannin and monoterpene, was isolated from the leaves of Eucalyptus globulus. Its structure was determined by spectral methods.
THE ZnO powder （micro-crystallites）, an important functional material, has a wide applica-tion in the fields of ceramics, coatings and electronic devices. However, the powder, usuallyobtained by calcination of zinc ...THE ZnO powder （micro-crystallites）, an important functional material, has a wide applica-tion in the fields of ceramics, coatings and electronic devices. However, the powder, usuallyobtained by calcination of zinc oxalate, has a wide particle-size distribution and poor sinteringactivities so various methods for its preparation have been developed. The hydrothermalmethod is widely used to prepare many superfine powders such as ZrO<sub>2</sub>, BaTiO<sub>3</sub>, PLZT, dueto many advantages compared with other methods. Recently, the powder of Ⅱ—Ⅵ com-pounds can also be prepared by this method. Furthermore, crystallite shapes may be consid-展开更多
From the aerial parts of Clerodendrum indicum, bye new compounds, cleroindicins B-F (1-5) were isolated and their structures identified by spectral method.
Two new diterpenoid glucosides, cleroserroside A and cleroserroside B, were isolatedfrom the aerial pans of Clerodendrum serratum var. amplexghlium Moldenke. Their structureswere characterized by spectral and chemical...Two new diterpenoid glucosides, cleroserroside A and cleroserroside B, were isolatedfrom the aerial pans of Clerodendrum serratum var. amplexghlium Moldenke. Their structureswere characterized by spectral and chemical methods.展开更多
Five new flavonoids were isolated from the aerial parts of Bidens pilosa L. var. vadiata Sch.-Bip.. Their structures were established on the basis of spectroscopic methods.
Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dion...Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dione 1 and 16 (s)-methoxymethyl-6 beta,7 beta-dihydroxy-7 alpha,20-epoxy-ent-kaur-2,3-ethenylene-1, 15-dione 2 respectively, by spectroscopic methods.展开更多
From the dried leaves of I. eriocalyx, three new 6,7-seco- ent-kaurane diterpenoids epi-eriocalyxin A (2), maoecrystal N (3) and maoecrystal O (4) were isolated. Meanwhile, the structure of a known constituent eriocal...From the dried leaves of I. eriocalyx, three new 6,7-seco- ent-kaurane diterpenoids epi-eriocalyxin A (2), maoecrystal N (3) and maoecrystal O (4) were isolated. Meanwhile, the structure of a known constituent eriocalyxin A was revised.展开更多
基金the"8th 5-year Plan"of National Administration Bureau of Traditional Chinese Medicine and Pharmacy,No.H09301
文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P【0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF.
文摘Erigoster A (la), a new compound with a novel basic skeleton, was isolated from Erigeron breviscapus. The structure elucidation and complete proton and carbon NMR assignments were achieved by the utilization of a combination of two-dimensional NMR techniques.
文摘The impacts of different 03 concentration on the biomass and yield of rice were studied by using OTC-1 open-top chambers. Experimental treatments included the activated charcoal-filtered air. (CFA), 50 nl/L (CF50), 100 nl/L ( CF100) and 200 nl/L (CF200) concentrations of O-3. The O-3 treatments significantly decreased the total biomass per plant. The. elevated O-3 exposure resulted in a more decrease in the root growth than in the shoot growth. Assessments of yield characteristics at the final harvest revealed an O-3-induced decrease in the number of grains per plant, resulting from fewer ears per plant, fewer grains per ear and more unfilled grains per ear. The 1000 grain dry weight and the harvest index (HI) were not changed significantly under 50 nl/L or 100 nl/L O-3 exposure, but reduced by 17.0% and 4.8% by 200nl/L O-3 treatment, respectively. Compared to the CFA treatment, CF50, CF100 and CF200 treatments caused a 8.2%, 26.1%, 49.1% decrease of the grain yield per plant, and a 14.2%, 31.7%, 51.7% decrease of the total biomass per plant, respectively. Linear regression showed that the 7h - daily mean O-3 concentration exposure for 3 months ( July-September) and AOT40 ( cunulative exposure accumulation over threshold 40 nl/L) were well correlated with the relative grain yield. A yield loss of 10% was estimated to be at 46.9 nl/L O-3 for 7h-daily mean O-3 concentration exposure or at 12930nl/(L(.)h) O-3 for AOT40.
基金supported by a grant from the Zhengzhou University Fund (340600532015)Henan Provincial Natural Science Foundation (112300410116)
文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure s
文摘Phytochemical re-investigation of the anti-leukemia plant Laggera pterodonta afford four new eudemsanes (1-4) and six new eudesmanoic glucosides (5-10), Their structures were elucidated by high field 1D and 2D NMR techniques and chemical methods.
文摘Four new diterpenoids named maoecrystal Q-T (1-4) were isolated from the dried leaves of Isodon eriocalyx. Their sturctures were established by spectroscopic methods.
文摘AIM To elucidate the effect of various solutions for small bowel graft preservation in pigs under hypothermic storage. METHODS The swine segmental small bowel graft was autotransplanted after it was preserved with lactated Ringer′s (LR), Euro Collins (EC), hyperosmolarity citrate adenine (HC A) and WMO 1 solutions for 10, 18 and 24 hours, respectively. The recipient survival rate, morphological structure, graft mucosal energy substances and Na + K + ATPase activity were studied, and graft absorption was estimated with D xylose absorption test. RESULTS The morphological study of the grafts preserved with LR or HC A solution for 10 hours or with EC and WMO 1 solution for 18 hours was normal 6 days after operation. Mucosal ATP, total adenine nucleotides (TAN) contents and Na + K + ATPase activity of the graft preserved with EC or WMO solution were higher than that of the graft preserved with LR or HC A solution. Serum level of D xylose was higher in EC and WMO 1 groups than in LR and HC A groups when the graft was preserved for 24 hours. CONCLUSIONS EC and WMO 1 solutions can preserve the swine small bowel up to 18 hours, which are superior to LR and HC A solutions.
文摘Ceratoside A (1), a new compound was isolated from the butanol-soluble fraction of Ceratostigma willmottianum, Its structure was determined by the utilization of 2D-NMR techniques.
文摘Eucaglobulin 1, a new complex of gallotannin and monoterpene, was isolated from the leaves of Eucalyptus globulus. Its structure was determined by spectral methods.
文摘THE ZnO powder （micro-crystallites）, an important functional material, has a wide applica-tion in the fields of ceramics, coatings and electronic devices. However, the powder, usuallyobtained by calcination of zinc oxalate, has a wide particle-size distribution and poor sinteringactivities so various methods for its preparation have been developed. The hydrothermalmethod is widely used to prepare many superfine powders such as ZrO<sub>2</sub>, BaTiO<sub>3</sub>, PLZT, dueto many advantages compared with other methods. Recently, the powder of Ⅱ—Ⅵ com-pounds can also be prepared by this method. Furthermore, crystallite shapes may be consid-
文摘From the aerial parts of Clerodendrum indicum, bye new compounds, cleroindicins B-F (1-5) were isolated and their structures identified by spectral method.
文摘Two new diterpenoid glucosides, cleroserroside A and cleroserroside B, were isolatedfrom the aerial pans of Clerodendrum serratum var. amplexghlium Moldenke. Their structureswere characterized by spectral and chemical methods.
文摘Five new flavonoids were isolated from the aerial parts of Bidens pilosa L. var. vadiata Sch.-Bip.. Their structures were established on the basis of spectroscopic methods.
文摘Two new diterpenoids, maoecrystal U and epi-maoecrystal P were isolated from the leaves of Isodon eriocalyx. Their structures were determined as 6 beta-acetoxy-15 beta-hydroxy-3 alpha, 20epoxy-ent-kaur-16-ene-1,7-dione 1 and 16 (s)-methoxymethyl-6 beta,7 beta-dihydroxy-7 alpha,20-epoxy-ent-kaur-2,3-ethenylene-1, 15-dione 2 respectively, by spectroscopic methods.
文摘From the dried leaves of I. eriocalyx, three new 6,7-seco- ent-kaurane diterpenoids epi-eriocalyxin A (2), maoecrystal N (3) and maoecrystal O (4) were isolated. Meanwhile, the structure of a known constituent eriocalyxin A was revised.
