Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is efficient.We developed the D...Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is efficient.We developed the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value out of CTA images in five minutes.This study is to evaluate the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value from CTA images as an efficient method.Methods A single-center,prospective study was conducted and 63 patients were enrolled for the evaluation of the diagnostic performance of DEEPVESSEL-FFR.Automatic quantification method for the three-dimensional coronary arterial geometry and the deep learning based prediction of FFR were developed to assess the ischemic risk of the stenotic coronary arteries.Diagnostic performance of the DEEPVESSEL-FFR was assessed by using wire-based FFR as reference standard.The primary evaluation factor was defined by using the area under receiver-operation characteristics curve(AUC)analysis.Results For per-patient level,taking the cut-off value<0.8 referring to the FFR measurement,DEEPVESSEL-FFR presented higher diagnostic performance in determining ischemia-related lesions with area under the curve of 0.928 compare to CTA stenotic severity 0.664.DEEPVESSEL-FFR correlated with FFR(R=0.686,P<0.001),with a mean di&ference of-0.006士0.0091(P=0.619).The secondary evaluation factors,indicating per vessel accuracy,sensitivity,specificity,positive predictive value,and negative predictive value were 87.3%,97.14%,75%,82.93%,and 95.45%,respectively.Conclusion DEEPVESSEL-FFR is a novel method that allows efficient assessment of the functional significance of coronary stenosis.展开更多
A novel energetic combustion catalyst, 4-amino-3,S-dinitropyrazole copper salt （[Cu（adnp）2（H2O）2]）, was synthesized in a yield of 93.6% for the first time. The single crystal of [Cu（adnp）2（H2O）2] was determi...A novel energetic combustion catalyst, 4-amino-3,S-dinitropyrazole copper salt （[Cu（adnp）2（H2O）2]）, was synthesized in a yield of 93.6% for the first time. The single crystal of [Cu（adnp）2（H2O）2] was determined by single crystal X-ray diffraction. It crystallizes in a triclinic system, space group p^-1 with crystal parameters a = 5.541（3） A, b = 7.926（4） A, c = 10.231（5） A,β = 101.372（8）°, V = 398.3（3） A3, Z = 1, μ = 1.467 mm^-1, F（0 0 0） = 243, and Dc = 2.000 g cm^-3. The thermal behavior and non-isothermal decomposition reaction kinetics of [Cu（adnp）2（H2O）2] were studied by means of different heating rate differential scanning calorimetry （DSC）. The kinetic equation of major exothermic decomposition reaction for [Cu（adnp）2（H2O）2] was obtained. The entropy of activation （△S≠）, enthalpy of activation （△H≠）, free energy of activation （△G≠）, the self-accelerating decomposition temperature （TSADT） and the critical temperature of thermal explosion （Tb） are 59.42 j mol^-1 K^-1, 169.5 kJ mol^-1, 1141.26 kJ mol ^-1 457.3 K and 468.1 K, respectively.展开更多
目的:观察针刺治疗睡眠觉醒时相延迟障碍(DSWPD)的临床疗效。方法:将84例DSWPD患者随机分为观察组(42例,脱落2例)和对照组(42例,脱落3例)。两组均予睡眠卫生健康宣教,在此基础上,观察组针刺申脉、照海、合谷、太冲、足三里、三阴交,对...目的:观察针刺治疗睡眠觉醒时相延迟障碍(DSWPD)的临床疗效。方法:将84例DSWPD患者随机分为观察组(42例,脱落2例)和对照组(42例,脱落3例)。两组均予睡眠卫生健康宣教,在此基础上,观察组针刺申脉、照海、合谷、太冲、足三里、三阴交,对照组于相同穴位予安慰针刺,均治疗8周,第1~4周隔日1次,每周3次;第5~8周隔2 d 1次,每周2次。治疗前后,观察两组患者睡眠体动记录仪(ACT)客观睡眠指标(总卧床时间、总睡眠时间、睡眠效率、觉醒次数、入睡后觉醒时间)及血浆皮质醇(CORT)含量;治疗前后及治疗结束后1、3个月随访时,观察两组患者早-晚问卷(MEQ)、失眠严重程度指数(ISI)、疲劳严重程度量表(FSS)、Epworth嗜睡量表(ESS)评分。结果:与治疗前比较,治疗后观察组总睡眠时间延长、睡眠效率提高、觉醒次数减少、入睡后觉醒时间缩短(P<0.01,P<0.05),且治疗后观察组上述指标均优于对照组(P<0.01,P<0.05)。与治疗前比较,两组治疗后及观察组随访1、3个月MEQ评分升高(P<0.01),且治疗后各时间点观察组MEQ评分均高于对照组(P<0.01)。观察组治疗后ISI、FSS、ESS评分及随访1、3个月ISI、ESS评分均较治疗前下降(P<0.01,P<0.05),且观察组治疗后各时间点ISI、FSS、ESS评分均低于对照组(P<0.01,P<0.05)。治疗后,观察组血浆CORT含量较治疗前降低(P<0.01),且低于对照组(P<0.05)。结论:针刺可改善DSWPD患者睡眠觉醒时相,提高其睡眠质量和日间功能状态,其机制可能与降低血浆CORT含量相关。展开更多
Background Prostate stromal cells are known to regulate epithelial growth as well as support and maintain epithelial function. However, how stromal cells regulate epithelial cells and what differences among various hi...Background Prostate stromal cells are known to regulate epithelial growth as well as support and maintain epithelial function. However, how stromal cells regulate epithelial cells and what differences among various histological/pathological prostate stromal cells in prostate cancer progression still remain unclear. This study aimed to investigate the different phenotypes of human various histological^pathological prostate stromal cells, and their role in tumor promotion. Methods The different phenotypes of the human normal prostatic peripheral zonal primary stromal cells （NPPF）, transitional zonal primary stromal cells （NPTF）,展开更多
Background The importance of heart rate as secondary prevention strategies for patients with coronary artery disease （CAD） is emphasized by multiple guidelines. However, limited information is available on the heart...Background The importance of heart rate as secondary prevention strategies for patients with coronary artery disease （CAD） is emphasized by multiple guidelines. However, limited information is available on the heart rate distribution and the change patterns of resting heart rate when initiating beta-blocker therapy among Chinese patients with CAD. Methods The REsults of Sympathetic Evaluation And Research of China （RESEARCH） study is a multi-centre, prospective, observational study involving 147 centers in 23 cities across China. All eligible beta-blocker naive patients were prescribed with metroprolol succinate. Initial dosage and target heart rate were selected at the discretion of their physicians in charge according to their usual institutional practice. The heart rate distribution and the change patterns of resting heart rate after initiation of beta-blocker therapy were observed. Results The majority of patients （63.6%） were prescribed with 47.5 mg metroprolol succinate. At baseline, there were only 17.4% of patients whose heart rate was less than 70 beats per minute, and the proportion reached 42.5% and 79.1%, one month and two months after initiation of beta-blockers, respectively. Multivariate linear regression analysis showed that baseline heart rate （B=0.900, SE=0.006, t=141.787, P〈0.0001） and the dosage （B=-0.007, SE=0.002, t=-3.242, P=0.001） were independent predictors of resting heart rate 2 months after beta-blocker therapy. Conclusions Resting heart rate is not optimally controlled in a broadly representative cohort of Chinese outpatients with CAD even after initiation of β-blocker therapy, and baseline heart rate and the dosage of beta-blocker are both independent predictors of resting heart rate after β-blocker therapy.展开更多
文摘Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is efficient.We developed the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value out of CTA images in five minutes.This study is to evaluate the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value from CTA images as an efficient method.Methods A single-center,prospective study was conducted and 63 patients were enrolled for the evaluation of the diagnostic performance of DEEPVESSEL-FFR.Automatic quantification method for the three-dimensional coronary arterial geometry and the deep learning based prediction of FFR were developed to assess the ischemic risk of the stenotic coronary arteries.Diagnostic performance of the DEEPVESSEL-FFR was assessed by using wire-based FFR as reference standard.The primary evaluation factor was defined by using the area under receiver-operation characteristics curve(AUC)analysis.Results For per-patient level,taking the cut-off value<0.8 referring to the FFR measurement,DEEPVESSEL-FFR presented higher diagnostic performance in determining ischemia-related lesions with area under the curve of 0.928 compare to CTA stenotic severity 0.664.DEEPVESSEL-FFR correlated with FFR(R=0.686,P<0.001),with a mean di&ference of-0.006士0.0091(P=0.619).The secondary evaluation factors,indicating per vessel accuracy,sensitivity,specificity,positive predictive value,and negative predictive value were 87.3%,97.14%,75%,82.93%,and 95.45%,respectively.Conclusion DEEPVESSEL-FFR is a novel method that allows efficient assessment of the functional significance of coronary stenosis.
基金the National Science Foundation of China(No.21173163 and No. 21303133)
文摘A novel energetic combustion catalyst, 4-amino-3,S-dinitropyrazole copper salt （[Cu（adnp）2（H2O）2]）, was synthesized in a yield of 93.6% for the first time. The single crystal of [Cu（adnp）2（H2O）2] was determined by single crystal X-ray diffraction. It crystallizes in a triclinic system, space group p^-1 with crystal parameters a = 5.541（3） A, b = 7.926（4） A, c = 10.231（5） A,β = 101.372（8）°, V = 398.3（3） A3, Z = 1, μ = 1.467 mm^-1, F（0 0 0） = 243, and Dc = 2.000 g cm^-3. The thermal behavior and non-isothermal decomposition reaction kinetics of [Cu（adnp）2（H2O）2] were studied by means of different heating rate differential scanning calorimetry （DSC）. The kinetic equation of major exothermic decomposition reaction for [Cu（adnp）2（H2O）2] was obtained. The entropy of activation （△S≠）, enthalpy of activation （△H≠）, free energy of activation （△G≠）, the self-accelerating decomposition temperature （TSADT） and the critical temperature of thermal explosion （Tb） are 59.42 j mol^-1 K^-1, 169.5 kJ mol^-1, 1141.26 kJ mol ^-1 457.3 K and 468.1 K, respectively.
文摘目的:观察针刺治疗睡眠觉醒时相延迟障碍(DSWPD)的临床疗效。方法:将84例DSWPD患者随机分为观察组(42例,脱落2例)和对照组(42例,脱落3例)。两组均予睡眠卫生健康宣教,在此基础上,观察组针刺申脉、照海、合谷、太冲、足三里、三阴交,对照组于相同穴位予安慰针刺,均治疗8周,第1~4周隔日1次,每周3次;第5~8周隔2 d 1次,每周2次。治疗前后,观察两组患者睡眠体动记录仪(ACT)客观睡眠指标(总卧床时间、总睡眠时间、睡眠效率、觉醒次数、入睡后觉醒时间)及血浆皮质醇(CORT)含量;治疗前后及治疗结束后1、3个月随访时,观察两组患者早-晚问卷(MEQ)、失眠严重程度指数(ISI)、疲劳严重程度量表(FSS)、Epworth嗜睡量表(ESS)评分。结果:与治疗前比较,治疗后观察组总睡眠时间延长、睡眠效率提高、觉醒次数减少、入睡后觉醒时间缩短(P<0.01,P<0.05),且治疗后观察组上述指标均优于对照组(P<0.01,P<0.05)。与治疗前比较,两组治疗后及观察组随访1、3个月MEQ评分升高(P<0.01),且治疗后各时间点观察组MEQ评分均高于对照组(P<0.01)。观察组治疗后ISI、FSS、ESS评分及随访1、3个月ISI、ESS评分均较治疗前下降(P<0.01,P<0.05),且观察组治疗后各时间点ISI、FSS、ESS评分均低于对照组(P<0.01,P<0.05)。治疗后,观察组血浆CORT含量较治疗前降低(P<0.01),且低于对照组(P<0.05)。结论:针刺可改善DSWPD患者睡眠觉醒时相,提高其睡眠质量和日间功能状态,其机制可能与降低血浆CORT含量相关。
基金This study was supported by the grants from the National Natural Science Foundation of China （No. 81072096） and the Science and Technology Commission of Shanghai Municipality （No. 074119518）.
文摘Background Prostate stromal cells are known to regulate epithelial growth as well as support and maintain epithelial function. However, how stromal cells regulate epithelial cells and what differences among various histological/pathological prostate stromal cells in prostate cancer progression still remain unclear. This study aimed to investigate the different phenotypes of human various histological^pathological prostate stromal cells, and their role in tumor promotion. Methods The different phenotypes of the human normal prostatic peripheral zonal primary stromal cells （NPPF）, transitional zonal primary stromal cells （NPTF）,
文摘Background The importance of heart rate as secondary prevention strategies for patients with coronary artery disease （CAD） is emphasized by multiple guidelines. However, limited information is available on the heart rate distribution and the change patterns of resting heart rate when initiating beta-blocker therapy among Chinese patients with CAD. Methods The REsults of Sympathetic Evaluation And Research of China （RESEARCH） study is a multi-centre, prospective, observational study involving 147 centers in 23 cities across China. All eligible beta-blocker naive patients were prescribed with metroprolol succinate. Initial dosage and target heart rate were selected at the discretion of their physicians in charge according to their usual institutional practice. The heart rate distribution and the change patterns of resting heart rate after initiation of beta-blocker therapy were observed. Results The majority of patients （63.6%） were prescribed with 47.5 mg metroprolol succinate. At baseline, there were only 17.4% of patients whose heart rate was less than 70 beats per minute, and the proportion reached 42.5% and 79.1%, one month and two months after initiation of beta-blockers, respectively. Multivariate linear regression analysis showed that baseline heart rate （B=0.900, SE=0.006, t=141.787, P〈0.0001） and the dosage （B=-0.007, SE=0.002, t=-3.242, P=0.001） were independent predictors of resting heart rate 2 months after beta-blocker therapy. Conclusions Resting heart rate is not optimally controlled in a broadly representative cohort of Chinese outpatients with CAD even after initiation of β-blocker therapy, and baseline heart rate and the dosage of beta-blocker are both independent predictors of resting heart rate after β-blocker therapy.
